Sylvie Amu
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View article: Current perspectives on mesenchymal stromal cell therapy for graft versus host disease
Current perspectives on mesenchymal stromal cell therapy for graft versus host disease Open
View article: Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males
Impact of chemokine C–C ligand 27, foreskin anatomy and sexually transmitted infections on HIV-1 target cell availability in adolescent South African males Open
We compared outer and inner foreskin tissue from adolescent males undergoing medical male circumcision to better understand signals that increase HIV target cell availability in the foreskin. We measured chemokine gene expression and the i…
View article: ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism Open
The A20-binding inhibitor of NF-κB 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component of the tumor progression locus 2 (Tpl2) kinase complex. We generated a knock-in mouse expressing the ubiquitin-binding–de…
View article: The immune system and stroke: from current targets to future therapy
The immune system and stroke: from current targets to future therapy Open
Stroke is a major cause of morbidity and mortality worldwide. Despite the intensive search for new therapies, hundreds of agents targeting various pathophysiological mechanisms have failed clinical trials, and the thrombolytic agent tissue…
View article: Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A
Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A Open
The helminth Schistosoma mansoni modulates the infected host's immune system to facilitate its own survival, by producing excretory/secretory molecules that interact with a variety of the host's cell types including those of the immune sys…
View article: Dendritic Cell Response to HIV-1 Is Controlled by Differentiation Programs in the Cells and Strain-Specific Properties of the Virus
Dendritic Cell Response to HIV-1 Is Controlled by Differentiation Programs in the Cells and Strain-Specific Properties of the Virus Open
Dendritic cells (DCs) are potent antigen-presenting cells that might play contradictory roles during HIV-1 infection, contributing not only to antiviral immunity but also to viral dissemination and immune evasion. Although DCs are characte…
View article: Immunogenicity is preferentially induced in sparse dendritic cell cultures
Immunogenicity is preferentially induced in sparse dendritic cell cultures Open
View article: Impaired B cells survival upon production of inflammatory cytokines by HIV-1 exposed follicular dendritic cells
Impaired B cells survival upon production of inflammatory cytokines by HIV-1 exposed follicular dendritic cells Open
FDC lines exposed to different HIV-1 strains, although not able to support productive HIV-1 replication, show an increased production of inflammatory cytokines. Our in vitro model of interactions between HIV-1 exposed FDC lines and B cells…
View article: Dysfunctional phenotypes of CD4+ and CD8+ T cells are comparable in patients initiating ART during early or chronic HIV-1 infection
Dysfunctional phenotypes of CD4+ and CD8+ T cells are comparable in patients initiating ART during early or chronic HIV-1 infection Open
Early initiation of antiretroviral therapy (ART) is becoming a common clinical practice according to current guidelines recommending treatment to all HIV-1-infected patients. However, it is not known whether ART initiated during the early …
View article: The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α. Open
An incorrect -actin immunoblot was inadvertently used to assemble Fig. 5B.The corrected figure is now shown.This error does not affect the interpretation of results or conclusions of this work.
View article: Suppressed diversity of survivin splicing in active rheumatoid arthritis
Suppressed diversity of survivin splicing in active rheumatoid arthritis Open
View article: Impaired Phenotype and Function of T Follicular Helper Cells in HIV-1-Infected Children Receiving ART
Impaired Phenotype and Function of T Follicular Helper Cells in HIV-1-Infected Children Receiving ART Open
T follicular helper (Tfh) cells are important components in development of specific humoral immune responses; whether the number and biology of Tfh cells is impaired in HIV-1-infected children is not yet studied.The frequency, phenotype, a…
View article: Ligation of TLR7 on CD19<sup>+</sup>CD1d<sup>hi</sup> B cells suppresses allergic lung inflammation via regulatory T cells
Ligation of TLR7 on CD19<sup>+</sup>CD1d<sup>hi</sup> B cells suppresses allergic lung inflammation via regulatory T cells Open
B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B‐cell population is defined as IL‐10‐producing CD19 + CD1d hi cells. Previous work has ident…