Sylvie Daliphard
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View article: Overestimation of Automated Platelet Counts by Blast Fragments in Acute Hypercellular Leukemias: A Retrospective Study Comparing Impedance, Optical (<scp>PLT</scp>‐O), Fluorescent (<scp>PLT</scp>‐F), and <scp>CD41</scp>/<scp>CD61</scp> Flow Cytometry Methods
Overestimation of Automated Platelet Counts by Blast Fragments in Acute Hypercellular Leukemias: A Retrospective Study Comparing Impedance, Optical (<span>PLT</span>‐O), Fluorescent (<span>PLT</span>‐F), and <span>CD41</span>/<span>CD61</span> Flow Cytometry Methods Open
Introduction Acute leukemias with hyperleukocytosis (> 100 × 10 9 /L) can produce cytoplasmic blast fragments that interfere with platelet counts, notably in impedance‐based methods, potentially masking severe thrombocytopenia and increasi…
View article: Four Cases of Myeloproliferative Disorders Associated With Down Syndrome: Distinguishing ML‐DS From TAM‐DS
Four Cases of Myeloproliferative Disorders Associated With Down Syndrome: Distinguishing ML‐DS From TAM‐DS Open
Down syndrome (DS) is defined by an extra copy of chromosome 21 and confers an increased susceptibility to hematological disorders. Transient abnormal myelopoiesis (TAM) and myeloid‐leukemia associated with Down syndrome (ML‐DS) are two co…
View article: Stability over time of immature platelet fraction and comparison between <scp>EDTA</scp> and citrated whole blood samples
Stability over time of immature platelet fraction and comparison between <span>EDTA</span> and citrated whole blood samples Open
Background Immature platelets (IP) are the youngest circulating platelets, released from megakaryocytes, and demonstrating increased dimensions, significant RNA content, and enhanced activity. Immature platelet research focuses on a differ…
View article: Perls’ Stain Guidelines from the French-Speaking Cellular Hematology Group (GFHC)
Perls’ Stain Guidelines from the French-Speaking Cellular Hematology Group (GFHC) Open
In order to standardize cellular hematology practices, the French-speaking Cellular Hematology Group (Groupe Francophone d’Hématologie Cellulaire, GFHC) focused on Perls’ stain. A national survey was carried out, leading to the proposal of…
View article: Assessment of Reticulocyte and Erythrocyte Parameters From Automated Blood Counts in Vaso-Occlusive Crisis on Sickle Cell Disease
Assessment of Reticulocyte and Erythrocyte Parameters From Automated Blood Counts in Vaso-Occlusive Crisis on Sickle Cell Disease Open
Sickle cell disease is a complex genetic disease involving cell adhesion between red blood cells, white blood cells, platelets and endothelial cells, inducing painful vaso-occlusive crisis (VOC). We assessed reticulocyte and erythrocyte pa…
View article: Successful treatment of T/myeloid mixed‐phenotype acute leukemia with the translocation (10;11)(p13;q14) <i>PICALM/AF10</i> with 3 + 7 myeloid standard treatment: A case report
Successful treatment of T/myeloid mixed‐phenotype acute leukemia with the translocation (10;11)(p13;q14) <i>PICALM/AF10</i> with 3 + 7 myeloid standard treatment: A case report Open
The translocation PICALM/AF10 is described in multilineage diseases. We report a patient with PICALM/AF10 T/myeloid mixed‐phenotype acute leukemia who achieved durable complete remission after AML‐like treatment suggesting a myeloid origin.
View article: Erythrocyte hemighosts in a patient with tumor lysis syndrome: One train may hide another
Erythrocyte hemighosts in a patient with tumor lysis syndrome: One train may hide another Open
Rasburicase was introduced to treat hyperuricemia secondary to tumor lysis syndrome. Because of severe hemolytic anemia, a blood smear was requested and showed hemighosts, revealing G6PD deficiency. Erythrocyte morphology is a key tool in …
View article: Hereditary pyropoïkilocytosis diagnosis in an infant: benefit of histograms and peripheral smear review
Hereditary pyropoïkilocytosis diagnosis in an infant: benefit of histograms and peripheral smear review Open
View article: Benefit of Howell-Jolly bodies detection: finding of an acquired hyposplenism in a patient with Goodpasture syndrome
Benefit of Howell-Jolly bodies detection: finding of an acquired hyposplenism in a patient with Goodpasture syndrome Open
Howell-Jolly bodies are intraerythrocytic inclusions corresponding to a small portion of chromatin. Red blood cells that contain these nuclear remnants are removed from the circulation by the spleen. In most cases, presence of Howell-Jolly…
View article: How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients?
How should we diagnose and treat blastic plasmacytoid dendritic cell neoplasm patients? Open
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive leukemia for which we developed a nationwide network to collect data from new cases diagnosed in France. In a retrospective, observational study of 86 patients (…
View article: Severe pancytopenia due to acute folate deficiency despite normal folate erythrocyte level
Severe pancytopenia due to acute folate deficiency despite normal folate erythrocyte level Open
We report the case of an alcoholic patient with severe pancytopenia with low plasma folate level but normal erythrocyte folates and cobalamin levels. The bone marrow smear concluded to a pancytopenia due to folates and/or cobalamin deficie…
View article: Haematological spectrum and genotype-phenotype correlations in nine unrelated families with RUNX1 mutations from the French network on inherited platelet disorders
Haematological spectrum and genotype-phenotype correlations in nine unrelated families with RUNX1 mutations from the French network on inherited platelet disorders Open
View article: Biological Description of 109 Cases of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) from the French Network of BPDCN
Biological Description of 109 Cases of Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) from the French Network of BPDCN Open
Blastic plasmacytoid dendritic cell neoplasm is a clonal disease derived from precursors of plasmacytoid dendritic cells (pDC). It is a rare neoplasm involving the skin which may or may not be associated from the outset with a leukemic com…
View article: Spontaneous remission in three cases of <scp>AML</scp> M5 with <i><scp>NPM</scp>1</i> mutation
Spontaneous remission in three cases of <span>AML</span> M5 with <i><span>NPM</span>1</i> mutation Open
Key Clinical Message Patients with NPM 1‐mutated AML M5 who develop spontaneous remission ( SR ) after antibiotic therapy at diagnosis seem to form a favorable prognosis and chemo sensitive subtype. We report three cases of AML M5 patients…
View article: Incidence of <scp>ATRX</scp> mutations in myelodysplastic syndromes, the value of microcytosis
Incidence of <span>ATRX</span> mutations in myelodysplastic syndromes, the value of microcytosis Open
Acquired α‐thalassemia myelodysplastic syndrome (MDS) (ATMDS) is an acquired syndrome characterized by a somatic point mutation or splicing defect in the ATRX gene in patients with myeloid disorders, primarily MDS. In a large MDS patient s…