Sylvie Dufour
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Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis Open
Metabolic dysfunction-associated steatohepatitis (MASH) represents a progressive form of steatotic liver disease which increases the risk for fibrosis and advanced liver disease. The accumulation of discrete species of bioactive lipids has…
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts Open
Previous studies highlight the potential for sodium-glucose cotransporter type 2 (SGLT2) inhibitors (SGLT2i) to exert cardioprotective effects in heart failure by increasing plasma ketones and shifting myocardial fuel utilization toward ke…
Non-canonical nuclear function of glutaminase cooperates with Wnt signaling to drive EMT during neural crest development Open
Metabolic reprograming has been linked to epithelial-to-mesenchymal transition (EMT) in cancer cells, but how it influences EMT in normal cells remains largely unknown. Here we explored how metabolism impacts delamination and migration of …
A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche Open
The first hematopoietic stem and progenitor cells (HSPCs) emerge in the Aorta-Gonad-Mesonephros (AGM) region of the mid-gestation mouse embryo. However, the precise nature of their supportive mesenchymal microenvironment remains largely un…
The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans Open
The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. We studied the effect of this variant on hepatic metabolism in homozygous carriers and non…
First person – Nioosha Nekooie Marnany Open
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Nioosha Nekooie Marnany is first author on ‘ Glucos…
Glucose oxidation drives trunk neural crest cell development and fate Open
Bioenergetic metabolism is a key regulator of cellular function and signaling, but how it can instruct the behavior of cells and their fate during embryonic development remains largely unknown. Here, we investigated the role of glucose met…
Data from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Loss of NM23-H1 expression correlates with the degree of metastasis and with unfavorable clinical prognosis in several types of human carcinoma. However, the mechanistic basis for the metastasis suppressor function of NM23-H1 is obscure. W…
Supplementary Movie 2 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Movie 2 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 2 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 2 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 6 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 6 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 10 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 10 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 11 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 11 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Data from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Loss of NM23-H1 expression correlates with the degree of metastasis and with unfavorable clinical prognosis in several types of human carcinoma. However, the mechanistic basis for the metastasis suppressor function of NM23-H1 is obscure. W…
Supplementary Figure 7 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 7 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 5 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 5 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Movie 1 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Movie 1 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 1 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 1 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 8 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 8 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 5 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 5 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 1 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 1 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 10 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 10 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Movie 1 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Movie 1 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 3 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 3 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 8 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 8 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 4 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 4 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 9 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 9 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells
Supplementary Figure 3 from Implication of Metastasis Suppressor <i>NM23-H1</i> in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells Open
Supplementary Figure 3 from Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells