Sylvie François
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View article: Extreme hypokalemia in an asymptomatic 40-year-old cachectic male
Extreme hypokalemia in an asymptomatic 40-year-old cachectic male Open
Hypokalemia is a relatively common electrolyte disturbance that, despite its frequency, can pose a serious threat when it occurs in patients with end-stage chronic illnesses. In many individuals, mild to moderate reductions in serum potass…
View article: Allogeneic Hematopoietic Stem Cell Transplantation for Elderly Acute Lymphoblastic Leukemia Patients: A Registry Study From the Société Francophone de Greffe de Moelle et Thérapie Cellulaire (<scp>SFGM</scp>‐<scp>TC</scp>)
Allogeneic Hematopoietic Stem Cell Transplantation for Elderly Acute Lymphoblastic Leukemia Patients: A Registry Study From the Société Francophone de Greffe de Moelle et Thérapie Cellulaire (<span>SFGM</span>‐<span>TC</span>) Open
There are very limited data regarding the outcomes of elderly patients with acute lymphoblastic leukemia (ALL) who undergo allogeneic hematopoietic stem cell transplantation (alloHSCT). A total of 316 ALL patients aged ≥ 60 years who under…
View article: A phase II study of ponatinib for prevention of relapse after allotransplantation in <i>FLT3</i> internal tandem duplication mutation positive (FLT3-ITD+) acute myeloid leukemia: the PONALLO trial
A phase II study of ponatinib for prevention of relapse after allotransplantation in <i>FLT3</i> internal tandem duplication mutation positive (FLT3-ITD+) acute myeloid leukemia: the PONALLO trial Open
Not available.
View article: P-2356. A SFGM-TC real-world study to characterize pediatric patients undergoing allogeneic Hematopoietic Stem Cell Transplantation (HSCT) and identify the cytomegalovirus (CMV) serology status of both recipients and their donors
P-2356. A SFGM-TC real-world study to characterize pediatric patients undergoing allogeneic Hematopoietic Stem Cell Transplantation (HSCT) and identify the cytomegalovirus (CMV) serology status of both recipients and their donors Open
Background The aim of this study was to perform a description of pediatric patients’ characteristics undergoing an allogeneic Hematopoietic Stem Cell Transplantation (HSCT) and to identify their cytomegalovirus (CMV) serology status and th…
View article: PD-1 blockade and allogeneic hematopoietic stem cell transplantation in Hodgkin lymphoma, a matter of time: a national study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire
PD-1 blockade and allogeneic hematopoietic stem cell transplantation in Hodgkin lymphoma, a matter of time: a national study on behalf of the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire Open
International audience
View article: Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir
Treatment for First Cytomegalovirus Infection Post–Hematopoietic Cell Transplant in the AURORA Trial: A Multicenter, Double-Blind, Randomized, Phase 3 Trial Comparing Maribavir With Valganciclovir Open
Background Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus (CMV) infection following hematopoietic cell transplant (HCT). A phase 2 study indicated efficacy of maribavir with fewer treatment-limiting toxicitie…
View article: Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS
Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS Open
View article: Nilotinib efficacy and safety as salvage treatment following imatinib intolerance and/or inefficacy in steroid refractory chronic graft-versus-host-disease (SR-cGVHD): a prospective, multicenter, phase II study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
Nilotinib efficacy and safety as salvage treatment following imatinib intolerance and/or inefficacy in steroid refractory chronic graft-versus-host-disease (SR-cGVHD): a prospective, multicenter, phase II study on behalf of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) Open
View article: Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS
Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS Open
Allogeneic hematopoietic stem cell transplantation remains the best curative option for higher-risk myelodysplastic syndrome. The presence of monosomal karyotype and/or complex karyotype abnormalities predicts inferior survival after allo-…
View article: Antibody response after 2 and 3 doses of SARS-CoV-2 mRNA vaccine in allogeneic hematopoietic cell transplant recipients
Antibody response after 2 and 3 doses of SARS-CoV-2 mRNA vaccine in allogeneic hematopoietic cell transplant recipients Open
Three reports address the protection of the vulnerable population of patients with hematologic malignancies in the face of the ongoing COVID pandemic. The reports suggest that some patients who fail to mount a B-cell response to vaccine ma…
View article: Antibody Response to 2-Dose Sars-Cov-2 mRNA Vaccine in Allogeneic Hematopoietic Cell Transplant Recipients
Antibody Response to 2-Dose Sars-Cov-2 mRNA Vaccine in Allogeneic Hematopoietic Cell Transplant Recipients Open
INTRODUCTION Immunocompromised patients have been excluded from initial trials evaluating SARS-CoV-2 mRNA vaccines and there is a critical need to warrant vaccine efficacy in hematopoietic stem cell transplant (HSCT) recipients. In this st…
View article: Impact of allogeneic stem cell transplantation comorbidity indexes after haplotransplant using post‐transplant cyclophosphamide
Impact of allogeneic stem cell transplantation comorbidity indexes after haplotransplant using post‐transplant cyclophosphamide Open
Background Three different scoring systems have been developed to assess pre‐transplant comorbidity in allogeneic hematopoietic stem cell transplantation (Allo‐HSCT): the Hematopoietic Cell Transplantation‐Specific Comorbidity Index, the C…
View article: Early Post-Transplantation Serum Ferritin Level Predicts Survival in Recipients of Haploidentical Stem Cell Transplantation Using Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis
Early Post-Transplantation Serum Ferritin Level Predicts Survival in Recipients of Haploidentical Stem Cell Transplantation Using Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis Open
The negative impact of high serum ferritin level (SFL) before and after allogeneic hematopoietic cell transplantation (allo-HSCT) on outcomes is well recognized. However, it is poorly documented in adults undergoing haploidentical HSCT (ha…
View article: Prophylactic or Preemptive Low-Dose Azacitidine and Donor Lymphocyte Infusion to Prevent Disease Relapse following Allogeneic Transplantation in Patients with High-Risk Acute Myelogenous Leukemia or Myelodysplastic Syndrome
Prophylactic or Preemptive Low-Dose Azacitidine and Donor Lymphocyte Infusion to Prevent Disease Relapse following Allogeneic Transplantation in Patients with High-Risk Acute Myelogenous Leukemia or Myelodysplastic Syndrome Open
Because of the persistently high rates of relapse of patients with high-risk acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) following allogeneic hematopoietic stem cell transplantation (allo-HSCT), post-transplantation…
View article: Intestinal derivation for digestive complications of graft versus host disease in adult patients: a case series and review of the literature
Intestinal derivation for digestive complications of graft versus host disease in adult patients: a case series and review of the literature Open
Background: Graft Versus Host Disease (GvHD) is a frequent complication of hematopoietic stem cell transplantation (HSCT).Acute GvHD can involve intestinal tract which requires temporary fasting in addition to immunosuppressive treatment.S…
View article: Possible clinical leptospirosis in two cats (Felis silvestris catus) from the south of the Santa Fe province
Possible clinical leptospirosis in two cats (Felis silvestris catus) from the south of the Santa Fe province Open
La leptospirosis es una enfermedad infecciosa causada por Leptospira spp.. No suele considerarse como parte del diagnóstico diferencial en los gatos enfermos, lo cual reviste un riesgo significativo en la salud pública. Se describen dos po…
View article: Natural history of GATA2 deficiency in a survey of 79 French and Belgian patients
Natural history of GATA2 deficiency in a survey of 79 French and Belgian patients Open
Heterozygous germline GATA2 mutations strongly predispose to leukemia, immunodeficiency, and/or lymphoedema. We describe a series of 79 patients (53 families) diagnosed since 2011, made up of all patients in France and Belgium, with…
View article: REDUCED INTENSITY (<scp>FB2</scp>) VS REDUCED TOXICITY MYELOABLATIVE (<scp>FB3‐4</scp>) FLUDARABINE/BUSULFAN‐BASED CONDITIONING REGIMENS FOR NON‐<scp>H</scp>ODGKIN LYMPHOMA (<scp>NHL</scp>) ALLOGRAFTED PATIENTS
REDUCED INTENSITY (<span>FB2</span>) VS REDUCED TOXICITY MYELOABLATIVE (<span>FB3‐4</span>) FLUDARABINE/BUSULFAN‐BASED CONDITIONING REGIMENS FOR NON‐<span>H</span>ODGKIN LYMPHOMA (<span>NHL</span>) ALLOGRAFTED PATIENTS Open
Introduction: Fludarabine/busulfan-based conditioning regimens are widely used in Europe for this purpose. Busulfan dose intensity discriminates between reduced intensity (FB2, 2 days of busulfan at 4 mg/Kg/d per os or 3.2 mg/kg/d iv) and …
View article: Salvage use of allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning from unrelated donors in multiple myeloma. A study by the Plasma Cell Disorders subcommittee of the European Group for Blood and Marrow Transplant Chronic Malignancies Working Party
Salvage use of allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning from unrelated donors in multiple myeloma. A study by the Plasma Cell Disorders subcommittee of the European Group for Blood and Marrow Transplant Chronic Malignancies Working Party Open
peer reviewed
View article: Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma
Safety and efficacy of allogeneic hematopoietic stem cell transplant after PD-1 blockade in relapsed/refractory lymphoma Open
Key Points HSCT after PD-1 blockade is feasible, although may be associated with increased early immune toxicity. PD-1 blockade may cause persistent depletion of PD1+ T cells and alterations in T-cell differentiation impacting subsequent t…
View article: Clofarabine versus fludarabine‐based reduced‐intensity conditioning regimen prior to allogeneic transplantation in adults with AML/MDS
Clofarabine versus fludarabine‐based reduced‐intensity conditioning regimen prior to allogeneic transplantation in adults with AML/MDS Open
We have retrospectively compared survivals between acute myeloid leukemia ( AML )/myelodysplastic syndrome ( MDS ) patients who received either a clofarabine/busulfan (CloB2A2) or a fludarabine/busulfan ( FB 2A2) RIC regimen for allogeneic…
View article: Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication<i>In Vitro</i>and Skin Pathogenesis<i>In Vivo</i>
Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication<i>In Vitro</i>and Skin Pathogenesis<i>In Vivo</i> Open
Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella upon primary infection and zoster upon reactivation from latency in sensory ganglion neurons. The replication of herpesviruses requires manipulation of cell signalin…
View article: Autologous stem cell transplantation for patients aged 60 years or older with refractory or relapsed classical Hodgkin’s lymphoma: a retrospective analysis from the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC)
Autologous stem cell transplantation for patients aged 60 years or older with refractory or relapsed classical Hodgkin’s lymphoma: a retrospective analysis from the French Society of Bone Marrow Transplantation and Cell Therapies (SFGM-TC) Open
View article: Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance
Factors associated with an increased risk of vertebral fracture in monoclonal gammopathies of undetermined significance Open
Monoclonal gammopathies of undetermined significance (MGUS) have been shown to be associated with an increased risk of fractures. This study describes prospectively the bone status of MGUS patients and determines the factors associated wit…
View article: Management of Myelodysplastic Syndrome Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation: A Study by the French Society of Bone Marrow Transplantation and Cell Therapies
Management of Myelodysplastic Syndrome Relapsing after Allogeneic Hematopoietic Stem Cell Transplantation: A Study by the French Society of Bone Marrow Transplantation and Cell Therapies Open
To find out prognostic factors and to investigate different therapeutic approaches, we report on 147 consecutive patients who relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for myelodysplastic syndrome (MDS).…
View article: Hematopoietic Stem Cell Transplantation in Multiple Myeloma: A Retrospective Study of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
Hematopoietic Stem Cell Transplantation in Multiple Myeloma: A Retrospective Study of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) Open
Because the indication of allograft (allogeneic stem cell transplantation [alloSCT]) for multiple myeloma (MM) has widened in recent years, thanks to the development of reduced-intensity conditionings (RIC), it is still unclear if myeloabl…