Sylvie Ramboz
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View article: A systematic assessment of robustness in CNS safety pharmacology
A systematic assessment of robustness in CNS safety pharmacology Open
Background and Purpose Irwin tests are key preclinical study elements for characterising drug‐induced neurological side effects. This multicentre study aimed to assess the robustness of Irwin tests across multinational sites during three s…
View article: A Systematic Assessment of Robustness in CNS Safety Pharmacology
A Systematic Assessment of Robustness in CNS Safety Pharmacology Open
Irwin tests are key preclinical study elements for characterizing drug-induced neurological side effects. This multicenter study aimed to assess the robustness of Irwin tests across multinational sites during three stages of protocol harmo…
View article: Enrichment analysis of phenotypic data for drug repurposing in rare diseases
Enrichment analysis of phenotypic data for drug repurposing in rare diseases Open
Drug-induced Behavioral Signature Analysis (DBSA), is a machine learning (ML) method for in silico screening of compounds, inspired by analytical methods quantifying gene enrichment in genomic analyses. When applied to behavioral data it c…
View article: Systematic assessment of the replicability and generalizability of preclinical findings: Impact of protocol harmonization across laboratory sites
Systematic assessment of the replicability and generalizability of preclinical findings: Impact of protocol harmonization across laboratory sites Open
The influence of protocol standardization between laboratories on their replicability of preclinical results has not been addressed in a systematic way. While standardization is considered good research practice as a means to control for u…
View article: Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model Open
We have developed an inducible Huntington's disease (HD) mouse model that allows temporal control of whole-body allele-specific mutant huntingtin (mHtt) expression. We asked whether moderate global lowering of mHtt (~50%) was sufficient fo…
View article: Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model
Benefits of global mutant huntingtin lowering diminish over time in a Huntington’s disease mouse model Open
We have developed a novel inducible Huntington’s disease (HD) mouse model that allows temporal control of whole-body allele-specific mutant Huntingtin (m Htt ) expression. We asked whether moderate global lowering of m Htt (∼50%) was suffi…
View article: The <i>GBA1</i> D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models
The <i>GBA1</i> D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models Open
Heterozygous mutations in the GBA1 gene – encoding lysosomal glucocerebrosidase (GCase) – are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased GCase activity …
View article: Systematic review of guidelines for internal validity in the design,conduct and analysis of preclinical biomedical experiments involvinglaboratory animalsSystematic review of guidelines for internal validity inthe design, conduct and analysis of preclinical biomedical experimentsinvolving laboratory animals
Systematic review of guidelines for internal validity in the design,conduct and analysis of preclinical biomedical experiments involvinglaboratory animalsSystematic review of guidelines for internal validity inthe design, conduct and analysis of preclinical biomedical experimentsinvolving laboratory animals Open
Over the last two decades, awareness of the negative repercussions of flaws in the planning, conduct and reporting of preclinical research involving experimental animals has been growing. Several initiatives have set out to increase transp…
View article: Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals
Protocol for a systematic review of guidelines for rigour in the design, conduct and analysis of biomedical experiments involving laboratory animals Open
All data, including extracted text and guidelines, will be stored in the SyRF platform. Elements of the included guidelines will be identified using a standardized extraction form. Reporting will follow the PRISMA guidelines as far as appl…