Sylvie Shen
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View article: Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML
Genome-Wide CRISPR-Cas9 Screening Identifies a Synergy between Hypomethylating Agents and SUMOylation Blockade in MDS/AML Open
Hypomethylating agents (HMAs) are frontline therapies effective at altering the natural course of Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are hallmarks of HMA the…
View article: Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs
Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs Open
Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay among transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs (FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2) bind regulatory …
View article: Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia
Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia Open
High-risk childhood leukemia has a poor prognosis because of treatment failure and toxic side effects of therapy. Drug encapsulation into liposomal nanocarriers has shown clinical success at improving biodistribution and tolerability of ch…
View article: Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells
Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells Open
Summary Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - bind regu…
View article: Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
DC increases tumor-infiltrating immune cells in Th-MYCN mice
View article: Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Copper lowering drugs increased NK-mediated cell death in vitro
View article: Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
TEPA did not affect tumor growth in an immunocompromised neuroblastoma xenograft model
View article: Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poo…
View article: Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
TEPA increases tumor-infiltrating immune cells in Th-MYCN mice
View article: Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Co-expression plots of VST-normalized gene expression profiles derived from TCGA datasets for PD-L1 and four copper-responsive genes
View article: Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S4 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
TEPA increases tumor-infiltrating immune cells in Th-MYCN mice
View article: Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Methods for Master Regulator Analysis
View article: Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Effect of copper levels on EGFR phosphorylation and PD-L1 protein stability
View article: Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S5 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
DC increases tumor-infiltrating immune cells in Th-MYCN mice
View article: Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S1 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Co-expression plots of VST-normalized gene expression profiles derived from TCGA datasets for PD-L1 and four copper-responsive genes
View article: Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Data from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poo…
View article: Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S7 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
TEPA did not affect tumor growth in an immunocompromised neuroblastoma xenograft model
View article: Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S3 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Effect of copper levels on EGFR phosphorylation and PD-L1 protein stability
View article: Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S6 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Copper lowering drugs increased NK-mediated cell death in vitro
View article: Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Effect of copper levels on PD-L1 expression and interferon stimulation in cancer cells
View article: Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Figure S2 from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Effect of copper levels on PD-L1 expression and interferon stimulation in cancer cells
View article: Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Master Regulator Analysis from Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Methods for Master Regulator Analysis
View article: Table S1-S6 from <i>N-Ras</i>–Induced Growth Suppression of Myeloid Cells Is Mediated by <i>IRF-1</i>
Table S1-S6 from <i>N-Ras</i>–Induced Growth Suppression of Myeloid Cells Is Mediated by <i>IRF-1</i> Open
Table S1-S6 from N-Ras–Induced Growth Suppression of Myeloid Cells Is Mediated by IRF-1
View article: Table S1-S6 from <i>N-Ras</i>–Induced Growth Suppression of Myeloid Cells Is Mediated by <i>IRF-1</i>
Table S1-S6 from <i>N-Ras</i>–Induced Growth Suppression of Myeloid Cells Is Mediated by <i>IRF-1</i> Open
Table S1-S6 from N-Ras–Induced Growth Suppression of Myeloid Cells Is Mediated by IRF-1
View article: Data from <i>N-Ras</i>–Induced Growth Suppression of Myeloid Cells Is Mediated by <i>IRF-1</i>
Data from <i>N-Ras</i>–Induced Growth Suppression of Myeloid Cells Is Mediated by <i>IRF-1</i> Open
Activating mutations in ras oncogenes occur at high frequency in human malignancies and expression of activated ras in immortalized cells lines is generally transforming. However, somewhat paradoxically, ectopic expression of ras in some m…
View article: Data from <i>N-Ras</i>–Induced Growth Suppression of Myeloid Cells Is Mediated by <i>IRF-1</i>
Data from <i>N-Ras</i>–Induced Growth Suppression of Myeloid Cells Is Mediated by <i>IRF-1</i> Open
Activating mutations in ras oncogenes occur at high frequency in human malignancies and expression of activated ras in immortalized cells lines is generally transforming. However, somewhat paradoxically, ectopic expression of ras in some m…
View article: HGG-09. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG
HGG-09. TARGETING FACILITATES CHROMATIN TRANSCRIPTION (FACT) AS A NOVEL STRATEGY THAT ENHANCES RESPONSE TO HISTONE DEACETYLASE (HDAC) INHIBITION IN DIPG Open
DIPG is an aggressive and incurable childhood brain tumour for which new treatments are needed. A high throughput drug screen of 3500 pharmaceutical compounds identified anti-malarials, including quinacrine as having potent activity agains…
View article: Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion
Intratumoral Copper Modulates PD-L1 Expression and Influences Tumor Immune Evasion Open
Therapeutic checkpoint antibodies blocking programmed death receptor 1/programmed death ligand 1 (PD-L1) signaling have radically improved clinical outcomes in cancer. However, the regulation of PD-L1 expression on tumor cells is still poo…