Szu‐Fu Chen
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View article: Assessment of Gait and Balance in Elderly Individuals with Knee Osteoarthritis Using Inertial Measurement Units
Assessment of Gait and Balance in Elderly Individuals with Knee Osteoarthritis Using Inertial Measurement Units Open
Knee osteoarthritis (OA) is a prevalent condition in older adults that often results in impaired gait and balance, increased risk of falls, and reduced quality of life. Conventional clinical assessments may not adequately capture these def…
View article: Intravenous Iron Sucrose for Acute Decompensated Heart Failure Patients with Reduced Ejection Fraction and Iron Deficiency
Intravenous Iron Sucrose for Acute Decompensated Heart Failure Patients with Reduced Ejection Fraction and Iron Deficiency Open
Background: The concurrent presence of iron deficiency (ID) and heart failure (HF) can worsen prognosis and reduce the quality of life for affected individuals. This study aimed to explore the effects of incorporating iron sucrose into sta…
View article: Age-Related Influence on Static and Dynamic Balance Abilities: An Inertial Measurement Unit-Based Evaluation
Age-Related Influence on Static and Dynamic Balance Abilities: An Inertial Measurement Unit-Based Evaluation Open
Balance control, a complex sensorimotor skill, declines with age. Assessing balance is crucial for identifying fall risk and implementing interventions in the older population. This study aimed to measure age-dependent changes in static an…
View article: Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage
Transient receptor potential vanilloid 1 inhibition reduces brain damage by suppressing neuronal apoptosis after intracerebral hemorrhage Open
Intracerebral hemorrhage (ICH) induces a complex sequence of apoptotic cascades and inflammatory responses, leading to neurological impairment. Transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel with high calci…
View article: Control Design for a Power-Assisted Mobile Trainer: Applied to Clinical Stroke Rehabilitation
Control Design for a Power-Assisted Mobile Trainer: Applied to Clinical Stroke Rehabilitation Open
This paper presents control design and implementation for a power-assisted mobile trainer that employs neuro-developmental treatment (NDT) principles. NDT is a gait rehabilitation technique for stroke patients that provides minimum interve…
View article: Low-intensity pulsed ultrasound ameliorates glia-mediated inflammation and neuronal damage in experimental intracerebral hemorrhage conditions
Low-intensity pulsed ultrasound ameliorates glia-mediated inflammation and neuronal damage in experimental intracerebral hemorrhage conditions Open
View article: Performance Evaluation for Clinical Stroke Rehabilitation via an Automatic Mobile Gait Trainer
Performance Evaluation for Clinical Stroke Rehabilitation via an Automatic Mobile Gait Trainer Open
This paper investigates the clinical efficacy of an automatic mobile trainer for gait training in stroke patients. Neuro-Developmental Treatment (NDT) is a rehabilitation method for stroke patients that enhances motor learning through repe…
View article: Superior Gait Symmetry and Postural Stability among Yoga Instructors—Inertial Measurement Unit-Based Evaluation
Superior Gait Symmetry and Postural Stability among Yoga Instructors—Inertial Measurement Unit-Based Evaluation Open
This study investigates gait symmetry and single-leg stance balance of professional yoga instructors versus age-matched typically developed controls using inertial measurement unit (IMU)-based evaluation. We recruited twenty-five yoga inst…
View article: Superior Gait Performance and Postural Stability among Yoga Instructors – Inertial Measurement Unit-Based Evaluation
Superior Gait Performance and Postural Stability among Yoga Instructors – Inertial Measurement Unit-Based Evaluation Open
Background Yoga movements involve a series of motions of the core and lower limb muscles that require constant body adjustments to maintain balance and proper body alignment. Inertial measurement unit, a wearable device that is consisted o…
View article: Superior gait performance and balance ability in Latin dancers
Superior gait performance and balance ability in Latin dancers Open
Background Latin dance consists of various fast and stability-challenging movements that require constant body adjustments to maintain proper posture and balance. Although human gaits are assumed to be symmetrical, several factors can cont…
View article: Evaluation of Post-Stroke Spasticity from the Subacute to Chronic Stages
Evaluation of Post-Stroke Spasticity from the Subacute to Chronic Stages Open
Spasticity measured using clinical scales, such as the modified Ashworth scale (MAS), may not sufficiently evaluate the effectiveness of therapeutic interventions and predict prognosis. This study aimed to compare changes in H-reflex excit…
View article: Gait Training for Hemiplegic Stroke Patients: Employing an Automatic Neural Development Treatment Trainer with Real Time Detection
Gait Training for Hemiplegic Stroke Patients: Employing an Automatic Neural Development Treatment Trainer with Real Time Detection Open
This paper presents a clinical rehabilitation protocol for stroke patients using a movable trainer, which can automatically execute a neurodevelopmental treatment (NDT) intervention based on key gait events. The trainer consists of gait de…
View article: Early Detection of Parkinson’s Disease by Neural Network Models
Early Detection of Parkinson’s Disease by Neural Network Models Open
This paper develops neural network models that can recognize Parkinson’s disease (PD) at its early stage. PD is a common neurodegenerative disorder that presents with progressive slow movement, tremor, limb rigidity, and gait alterations, …
View article: Differential Changes in Akt and AMPK Phosphorylation Regulating mTOR Activity in the Placentas of Pregnancies Complicated by Fetal Growth Restriction and Gestational Diabetes Mellitus With Large-For-Gestational Age Infants
Differential Changes in Akt and AMPK Phosphorylation Regulating mTOR Activity in the Placentas of Pregnancies Complicated by Fetal Growth Restriction and Gestational Diabetes Mellitus With Large-For-Gestational Age Infants Open
Background: Dysregulation of placental mechanistic target of rapamycin (mTOR) activity has been implicated in the pathophysiology of pregnancies complicated by idiopathic fetal growth restriction (FGR) and gestational diabetes mellitus (GD…
View article: Antenatal low‐intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone‐induced intrauterine growth restriction
Antenatal low‐intensity pulsed ultrasound reduces neurobehavioral deficits and brain injury following dexamethasone‐induced intrauterine growth restriction Open
Intrauterine growth restriction (IUGR) is a leading cause of perinatal mortality and morbidity, and IUGR survivors are at increased risk of neurodevelopmental deficits. No effective interventions are currently available to improve the stru…
View article: Detection and Classification of Stroke Gaits by Deep Neural Networks Employing Inertial Measurement Units
Detection and Classification of Stroke Gaits by Deep Neural Networks Employing Inertial Measurement Units Open
This paper develops Deep Neural Network (DNN) models that can recognize stroke gaits. Stroke patients usually suffer from partial disability and develop abnormal gaits that can vary widely and need targeted treatments. Evaluation of gait p…
View article: Real-Time Detection of Gait Events by Recurrent Neural Networks
Real-Time Detection of Gait Events by Recurrent Neural Networks Open
This paper proposes a gait detection model that can recognize important gait events in real time. Human gaits are periodic, with each gait cycle containing the important gait events of mid-swing, heel-strike (HS), and toe-off. The correct …
View article: Risk factors and adverse maternal and perinatal outcomes for women with dichorionic twin pregnancies complicated by gestational diabetes mellitus: A retrospective cross‐sectional study
Risk factors and adverse maternal and perinatal outcomes for women with dichorionic twin pregnancies complicated by gestational diabetes mellitus: A retrospective cross‐sectional study Open
Aims/Introduction The association between gestational diabetes mellitus (GDM) and adverse maternal and perinatal outcomes in twin pregnancies remains unclear. This study was undertaken to highlight risk factors for GDM in women with dichor…
View article: Risk factors for abnormal postpartum glycemic states in women diagnosed with gestational diabetes by the International Association of Diabetes and Pregnancy Study Groups criteria
Risk factors for abnormal postpartum glycemic states in women diagnosed with gestational diabetes by the International Association of Diabetes and Pregnancy Study Groups criteria Open
Aims/Introduction To evaluate the rate of postpartum glycemic screening tests (PGST) in women with gestational diabetes mellitus (GDM), and to investigate risk factors for abnormal PGST results. Materials and Methods We retrospectively ana…
View article: Increased Soluble Epoxide Hydrolase in Human Gestational Tissues from Pregnancies Complicated by Acute Chorioamnionitis
Increased Soluble Epoxide Hydrolase in Human Gestational Tissues from Pregnancies Complicated by Acute Chorioamnionitis Open
Chorioamnionitis (CAM) is primarily a polymicrobial bacterial infection involving chorionic and amniotic membranes that is associated with increased risk of preterm delivery. Epoxyeicosatrienoic acids (EETs) are eicosanoids generated from …
View article: Soluble epoxide hydrolase in the human placenta throughout gestation
Soluble epoxide hydrolase in the human placenta throughout gestation Open
View article: Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage
Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage Open
Our findings demonstrate that the activation of TrkB signaling by 7,8-DHF protects against ICH via the Akt, but not the Erk, pathway. These data provide new insights into the role of TrkB signaling deficit in the pathophysiology of ICH and…
View article: A comparison of the efficacy of carbetocin and oxytocin on hemorrhage-related changes in women with cesarean deliveries for different indications
A comparison of the efficacy of carbetocin and oxytocin on hemorrhage-related changes in women with cesarean deliveries for different indications Open
Carbetocin and oxytocin had differential effects on hemorrhage-related changes in women with CS for different indications.
View article: Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage
Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage Open
View article: Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury
Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury Open
Traumatic brain injury (TBI) induces a series of inflammatory processes that contribute to neuronal damage. The present study investigated the involvement of soluble epoxide hydrolase (sEH) in neuroinflammation and brain damage in mouse TB…
View article: Performing Repeated Quantitative Small-Animal PET with an Arterial Input Function Is Routinely Feasible in Rats
Performing Repeated Quantitative Small-Animal PET with an Arterial Input Function Is Routinely Feasible in Rats Open
Performing quantitative small-animal PET with an arterial input function has been considered technically challenging. Here, we introduce a catheterization procedure that keeps a rat physiologically stable for 1.5 mo. We demonstrated the fe…
View article: Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage
Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage Open
View article: Additional file 1: Figure S1. of Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage
Additional file 1: Figure S1. of Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage Open
Effects of 3 different doses of TO901317 on collagenase-induced ICH in mice. (A) In all treatment groups, the mNSSs were significantly lower than the vehicle group at 4 and 7 days post-ICH. (B) There was no significant difference between t…
View article: Berberine reduced interleukin-1<b>β</b> (IL-1β)-induced activation of mixed glia and microglia and protected neurons against microglia-mediated neurotoxicity <i>in vitro</i>.
Berberine reduced interleukin-1<b>β</b> (IL-1β)-induced activation of mixed glia and microglia and protected neurons against microglia-mediated neurotoxicity <i>in vitro</i>. Open
(A) Treatment with 1, 5, 10 or 50 µM berberine immediately after stretch injury for 1 day did not affect cell viability by 3-[4,5-dimethyl-2-thiazolyl]- 2,5-diphenyl-2-tetrazolium bromide (MTT) assay. (B) In primary mixed gli…
View article: Effects of reducing the transcription of LC3B, beclin-1 and DRAM on the levels of M30 in cytotrophoblasts under hypoxia.
Effects of reducing the transcription of LC3B, beclin-1 and DRAM on the levels of M30 in cytotrophoblasts under hypoxia. Open
To study the relationship between autophagy and apoptosis in cytotrophoblasts under hypoxia, the cells were transfected with LC3B, beclin-1 and DRAM-specific siRNA, and the levels of M30 were measured after 48 hours of incubation at 2% oxy…