Explanipedia

Simultaneous vaccination against influenza and respiratory syncytial virus in high‐risk heart failure patients Open

Jan Biegus, Leszek Szenborn, Michał Tkaczyszyn, Robert Zymliński, Gad Cotter , et al. · 2025

Background There is a scarcity of prospective data on the impact of available vaccinations against respiratory viruses on hard clinical endpoints in patients with heart failure (HF). Aims We investigated whether, in the population of high‐…

PARROT: An Open Multilingual Radiology Reports Dataset Open

Bastien Le Guellec, Kokou Adambounou, Lisa C Adams, Thibault Agripnidis, Sung Soo Ahn , et al. · 2025

Rationale and Objectives: To develop and validate PARROT (Polyglottal Annotated Radiology Reports for Open Testing), a large, multicentric, open-access dataset of fictional radiology reports spanning multiple languages for testing natural …

A placebo-adjusted effect of the initial eGFR decline following SGLT-2 inhibitor initia-tion: a systematic review and meta-analysis Open

Szymon Urban, Jan Biegus, Mikołaj Błaziak, Gracjan Iwanek, Michał Fułek , et al. · 2025

Unlike in the placebo arms of RCTs, where an eGFR dip was associated with unfavorable outcomes, the early eGFR dip in the patients receiving SGLT‑2is was either neutral or beneficial. The SGLT-2i-related eGFR dip appears to confer a partic…

Cellular Prion Protein and Amyloid-β Oligomers in Alzheimer’s Disease—Are There Connections? Open

Michał Fułek, Naomi Hachiya, Martyna Gachowska, Jan Aleksander Beszłej, Elżbieta Bartoszewska , et al. · 2025

Alzheimer’s disease (AD) is the most common cause of dementia worldwide. Pathological deposits of neurotoxin proteins within the brain, such as amyloid-β and hyperphosphorylated tau tangles, are prominent features in AD. The prion protein …

The safety profile of deferred revascularization in patients with coronary artery disease undergoing non-hyperemic functional assessments Open

Mikołaj Błaziak, Szymon Urban, Weronika Wietrzyk, Maksym Jura, Izabella Świerczek , et al. · 2025

Deferred revascularization guided by dPR and RFR appears safe, with outcomes comparable to FFR-guided decisions in the literature. Larger randomized trials are needed to confirm these findings.

Potential effects of beta-blockers in HFpEF Open

Wojciech Tokarczyk, Szymon Urban, Patryk Patrzałek, Łukasz Stolarski, Gracjan Iwanek , et al. · 2024

Heart failure with preserved ejection fraction (HFpEF) poses a significant challenge in contemporary medicine, characterized by poor quality of life, high healthcare costs, and increased mortality. Despite advancements in medical research,…

e-Concilium: An online platform for cardiology consultation — results from a pilot study Open

Mikołaj Błaziak, Tomasz Jeruzalski, Paweł Pławiak, J. Granát, Jarosław Czerkies , et al. · 2024

Current Review of Heart Failure-Related Risk and Prognostic Factors Open

Michał Maksymilian Wilk, Jakub Wilk, Szymon Urban, Piotr Gajewski · 2024

Heart failure (HF) is a complex clinical syndrome characterized by the heart’s inability to maintain sufficient circulation, leading to inadequate organ perfusion and fluid buildup. A thorough understanding of the molecular, biochemical, a…

Fractional flow reserve versus solely angiography-guided revascularisation in coronary artery disease. Systematic review and meta-analysis Open

Mikołaj Błaziak, Szymon Urban, Maksym Jura, Weronika Wietrzyk, Bartłomiej Stańczykiewicz , et al. · 2024

FFR-driven revascularization was associated with a significantly lower rate of MI for the entire population and also the acute coronary syndrome subset. These results were achieved with substantially fewer revascularization procedures comp…

AI driven mechanical circulatory support: Can AI and Impella team up to beat cardiogenic shock Open

Robert Zymliński, Wojciech Tokarczyk, Szymon Urban · 2024

Temporary mechanical circulatory support (MCS) has recently become indispensable in the treatment of cardiogenic shock and serves as a crucial backup for high-risk percutaneous coronary interventions (PCI).1 However, the crucial elements l…

Effectiveness of remote pulmonary artery pressure estimating in heart failure: systematic review and meta-analysis Open

Szymon Urban, Oskar Szymański, Magdalena Grzesiak, Wojciech Tokarczyk, Mikołaj Błaziak , et al. · 2024

Phenotype clustering of hospitalized high-risk patients with COVID-19 — a machine learning approach within the multicentre, multinational PCHF-COVICAV registry Open

Mateusz Sokolski, Sander Trenson, Konrad Reszka, Szymon Urban, Justyna M. Sokolska , et al. · 2024

The ML process has identified three important clinical clusters from hospitalized COVID-19 CV and/or RF patients. The cluster of males with severe CV disease, particularly HF, and multiple RF presenting with increased inflammation had a pa…

The early safety profile of simultaneous vaccination against influenza and Respiratory Syncytial Virus (RSV) in patients with high-risk heart failure Open

Jan Biegus, Leszek Szenborn, Robert Zymliński, Michał Zakliczyńśki, Krzysztof Reczuch , et al. · 2024

The safety of simultaneous vaccination for Respiratory Syncytial Virus (RSV) and influenza in vulnerable high-risk heart failure (HF) patients remains unclear. In an open-label, prospective study, 105 patients received concurrent influenza…

Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic Open

Piotr Gajewski, Mikołaj Błaziak, Szymon Urban, Mateusz Garus, Frieder Braunschweig , et al. · 2023

Sex-stratified patterns of emergency cardiovascular admissions prior and during the COVID-19 pandemic Open

Piotr Gajewski, Mikołaj Błaziak, Szymon Urban, Mateusz Garus, Freider Braunschweig , et al. · 2023

The COVID-19 pandemic has had a significant impact on global public health, with long-term consequences that are still largely unknown. This study aimed to assess the data regarding acute cardiovascular hospital admissions in five European…

The diuretic, natriuretic and chloride-regaining effects of oral acetazolamide as an add-on therapy for acute heart failure with volume overload. A single center, prospective, randomized study Open

Aneta Kosiorek, Szymon Urban, Jerzy Detyna, Jan Biegus, Magdalena Hurkacz , et al. · 2023

Oral acetazolamide seems to be a valuable add‑on therapy that helps achieve comprehensive decongestion in patients with AHF.

Role of dietary sodium restriction in chronic heart failure: systematic review and meta-analysis Open

Szymon Urban, Michał Fułek, Mikołaj Błaziak, Katarzyna Fułek, Gracjan Iwanek , et al. · 2023

Background Dietary sodium restriction remains a guidelines-approved lifestyle recommendation for chronic heart failure (CHF) patients. However, its efficacy in clinical outcome improvement is dubious. Objective The study evaluated whether …

Role of dietary sodium restriction in chronic heart failure. Systematic review and meta-analysis. Open

Szymon Urban, Michał Fułek, Mikołaj Błaziak, Katarzyna Fułek, Gracjan Iwanek , et al. · 2023

Background Dietary sodium restriction remains guidelines-approved lifestyle recommendation for chronic heart failure (CHF) patients. However, its efficacy in clinical outcome improvement is dubious. Methods We performed a systematic review…

Renal Assessment in Acute Cardiorenal Syndrome Open

Piotr Łagosz, Jan Biegus, Szymon Urban, Robert Zymliński · 2023

Cardiorenal syndrome (CRS) is a complex, heterogeneous spectrum of symptoms that has kept cardiologists awake for decades. The heart failure (HF) population being burdened with multimorbidity poses diagnostic and therapeutic challenges eve…

Deferment of revascularization in ST-elevation myocardial infarction with coexisting aortic intramural hematoma Open

Mikołaj Błaziak, Szymon Urban, Weronika Wietrzyk, Michał Jarocki, Katarzyna Modrzejewska , et al. · 2023

AMA Błaziak M, Urban S, Wietrzyk W, Jarocki M, Modrzejewska K, Kuliczkowski W. Deferment of revascularization in ST-elevation myocardial infarction with coexisting aortic intramural hematoma. Advances in Interventional Cardiology/Postępy w…

A Methodological Perspective on the Function and Assessment of Peripheral Chemoreceptors in Heart Failure: A Review of Data from Clinical Trials Open

Maksym Jura, Mateusz Garus, Kornelia Krakowska, Szymon Urban, Mikołaj Błaziak , et al. · 2022

Augmented peripheral chemoreceptor sensitivity (PChS) is a common feature of many sympathetically mediated diseases, among others, and it is an important mechanism of the pathophysiology of heart failure (HF). It is related not only to the…

Machine Learning Approach to Understand Worsening Renal Function in Acute Heart Failure Open

Szymon Urban, Mikołaj Błaziak, Maksym Jura, Gracjan Iwanek, Barbara Ponikowska , et al. · 2022

Acute heart failure (AHF) is a common and severe condition with a poor prognosis. Its course is often complicated by worsening renal function (WRF), exacerbating the outcome. The population of AHF patients experiencing WRF is heterogenous,…

Patterns of Locus of Control in People Suffering from Heart Failure: An Approach by Clustering Method Open

Agnieszka Siennicka, Maciej Pondel, Szymon Urban, Ewa A. Jankowska, Beata Ponikowska , et al. · 2022

Background and Objectives: The assumption of responsibility in dealing with chronic diseases is of relevance in a resource-oriented and not only deficit-oriented medicine, especially in dealing with chronic diseases, including patients wit…

Avulsion fractures of the pelvis in the pediatric population. A review of the literature and case report Open

Szymon Urban, Justyna Napora, Szymon Wałejko, Tomasz Mazurek · 2022

Avulsion fractures of the pelvis usually occur in young athletes and are the most common type of avulsion fractures in the pediatric population. The most frequent fractures of this group are fractures of the anterior superior and anterior …

COVID-19 Related Myocarditis in Adults: A Systematic Review of Case Reports Open

Szymon Urban, Michał Fułek, Mikołaj Błaziak, Gracjan Iwanek, Maksym Jura , et al. · 2022

Despite the progress of its management, COVID-19 maintains an ominous condition which constitutes a threat, especially for the susceptible population. The cardiac injury occurs in approximately 30% of COVID-19 infections and is associated …

An Artificial Intelligence Approach to Guiding the Management of Heart Failure Patients Using Predictive Models: A Systematic Review Open

Mikołaj Błaziak, Szymon Urban, Weronika Wietrzyk, Maksym Jura, Gracjan Iwanek , et al. · 2022

Heart failure (HF) is one of the leading causes of mortality and hospitalization worldwide. The accurate prediction of mortality and readmission risk provides crucial information for guiding decision making. Unfortunately, traditional pred…

Novel Therapeutic Devices in Heart Failure Open

Mateusz Guzik, Szymon Urban, Gracjan Iwanek, Jan Biegus, Piotr Ponikowski , et al. · 2022

Heart failure (HF) constitutes a significant clinical problem and is associated with a sizeable burden for the healthcare system. Numerous novel techniques, including device interventions, are investigated to improve clinical outcome. A re…

Novel Phenotyping for Acute Heart Failure—Unsupervised Machine Learning-Based Approach Open

Szymon Urban, Mikołaj Błaziak, Maksym Jura, Gracjan Iwanek, Agata Zdanowicz , et al. · 2022

Acute heart failure (AHF) is a life-threatening, heterogeneous disease requiring urgent diagnosis and treatment. The clinical severity and medical procedures differ according to a complex interplay between the deterioration cause, underlyi…

Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure Open

Agata Zdanowicz, Szymon Urban, Barbara Ponikowska, Gracjan Iwanek, Robert Zymliński , et al. · 2022

Heart failure is a major public health problem and, despite the constantly emerging, new, effective treatments, it remains a leading cause of morbidity and mortality. Reliable tools for early diagnosis and risk stratification are crucial i…

Biomarkers of Myocardial Injury and Remodeling in Heart Failure Open

Barbara Ponikowska, Gracjan Iwanek, Agata Zdanowicz, Szymon Urban, Robert Zymliński , et al. · 2022

With its complicated pathophysiology, high incidence and prevalence, heart failure remains a major public concern. In hopes of improving diagnosis, treatment and prognosis, the utility of many different biomarkers is researched vigorously …

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