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View article: Macroscopic and microscopic biomechanical analysis of mineralized spheroids derived by mesenchymal stem cells
Macroscopic and microscopic biomechanical analysis of mineralized spheroids derived by mesenchymal stem cells Open
Three-dimensional cultures that simulate bone formation in vitro are promising approaches for elucidating the mineralization process involved in osteogenesis. In this study, we performed a multiscale analysis of spheroids derived from huma…
View article: An energy landscape-based theoretical framework for understanding the self-organization of functions in a living system under the dynamical component interaction
An energy landscape-based theoretical framework for understanding the self-organization of functions in a living system under the dynamical component interaction Open
In a living system composed of interacting components such as molecules, cells, and tissues, each component often changes its internal states in response to interactions with its surrounding components. For example, individual tissues exhi…
View article: Distinct dermal fibroblasts direct mechano-chemical signaling to the epidermis during pregnancy
Distinct dermal fibroblasts direct mechano-chemical signaling to the epidermis during pregnancy Open
Dermal fibroblasts alter extracellular matrix (ECM) and tissue mechanics dynamically in wound healing and fibrosis, however, are understudied in healthy skin remodeling across life stages. Here, by conducting spatio-temporal transcriptomic…
View article: Correction: Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel
Correction: Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel Open
View article: Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis
Emerging mechanomedicines informed by mechanotransduction along the integrin–cytoskeleton–nucleus axis Open
Mechanical forces are fundamental to the formation of normal biological tissues and the maintenance of physiological health. These forces are transmitted from the extracellular environment to the cell interior through cell–cell and cell–EC…
View article: In silico model of mechano-biochemical bone remodeling characterizes the therapeutic effects of osteoporosis drugs depending on the action mechanism
In silico model of mechano-biochemical bone remodeling characterizes the therapeutic effects of osteoporosis drugs depending on the action mechanism Open
Osteoporosis stems from an imbalance between bone resorption and formation during bone remodeling, a mechano-biochemical coupling event that intercellular signaling regulates among the bone cells in response to the mechanical environment. …
View article: An energy landscape-based theoretical framework for understanding the emergence of functions in a living system under the dynamical component interaction
An energy landscape-based theoretical framework for understanding the emergence of functions in a living system under the dynamical component interaction Open
In a living system composed of interacting components such as molecules, cells, and tissues, each component often adaptively changes its internal states in response to interactions with its surrounding components. For example, individual t…
View article: PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain
PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain Open
View article: Dynamic interactions between cartilaginous and tendinous/ligamentous primordia during musculoskeletal integration
Dynamic interactions between cartilaginous and tendinous/ligamentous primordia during musculoskeletal integration Open
Proper connections between cartilaginous and muscular primordia through tendinous/ligamentous primordia are essential for musculoskeletal integration. Herein, we report a novel double-reporter mouse model for investigating this process via…
View article: PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain
PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain Open
The migration of newborn neurons is essential for brain morphogenesis and circuit formation, yet controversy exists regarding how neurons generate the driving force against strong mechanical stresses in crowded neural tissues. We found tha…
View article: Cyclic stress measurement method using electrodeposited copper foil (Principal stress measurement using Debye ring of X-ray diffraction)
Cyclic stress measurement method using electrodeposited copper foil (Principal stress measurement using Debye ring of X-ray diffraction) Open
When a copper foil is adhered to a machine element subjected to repeated loads, grains grow in the foil. It has already been revealed that the maximum shear stress and principal stresses, which are important in evaluating the fatigue stren…
View article: Timing of resting zone parathyroid hormone-related protein expression affects maintenance of the growth plate during secondary ossification: a computational study
Timing of resting zone parathyroid hormone-related protein expression affects maintenance of the growth plate during secondary ossification: a computational study Open
View article: Super-resolution imaging reveals nucleolar encapsulation by single-stranded DNA
Super-resolution imaging reveals nucleolar encapsulation by single-stranded DNA Open
In eukaryotic cell nuclei, specific sets of proteins gather in nuclear bodies and facilitate distinct genomic processes. The nucleolus, a nuclear body, functions as a factory for ribosome biogenesis by accumulating constitutive proteins, s…
View article: Spatiotemporal analysis of multi-scale cell structure in spheroid culture reveals hypertrophic chondrocyte differentiation
Spatiotemporal analysis of multi-scale cell structure in spheroid culture reveals hypertrophic chondrocyte differentiation Open
View article: Modeling a triclinic lattice elastic body based on the linear couple stress theory
Modeling a triclinic lattice elastic body based on the linear couple stress theory Open
Triclinic lattice structures with generalized parallelepiped unit cells are crucial targets in understanding the influence of lattice structure on the mechanical behaviors of lattice elastic bodies. This study models a three-dimensional el…
View article: Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity
Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity Open
Fibrocartilaginous entheses consist of tendons, unmineralized and mineralized fibrocartilage, and subchondral bone, each exhibiting varying stiffness. Here we examined the functional role of sclerostin, expressed in mature mineralized fibr…
View article: Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel
Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel Open
Human pluripotent stem cells (hPSCs) dynamically respond to their chemical and physical microenvironment, dictating their behavior. However, conventional in vitro studies predominantly employ plastic culture wares, which offer a simplified…
View article: Mathematical expansion and clinical application of chronic kidney disease stage as vector field
Mathematical expansion and clinical application of chronic kidney disease stage as vector field Open
There are cases in which CKD progression is difficult to evaluate, because the changes in estimated glomerular filtration rate (eGFR) and proteinuria sometimes show opposite directions as CKD progresses. Indices and models that enable the …
View article: Chondrocyte hypertrophy in the growth plate promotes stress anisotropy affecting long bone development through chondrocyte column formation
Chondrocyte hypertrophy in the growth plate promotes stress anisotropy affecting long bone development through chondrocyte column formation Open
The length of long bones is determined by column formation of proliferative chondrocytes and subsequent chondrocyte hypertrophy in the growth plate during bone development. Despite the importance of mechanical loading in long bone developm…
View article: The nucleolar shell provides anchoring sites for DNA untwisting
The nucleolar shell provides anchoring sites for DNA untwisting Open
DNA underwinding (untwisting) is a crucial step in transcriptional activation. DNA underwinding occurs between the site where torque is generated by RNA polymerase (RNAP) and the site where the axial rotation of DNA is constrained. However…
View article: New marker for chronic kidney disease progression and mortality in medical-word virtual space
New marker for chronic kidney disease progression and mortality in medical-word virtual space Open
A new marker reflecting the pathophysiology of chronic kidney disease (CKD) has been desired for its therapy. In this study, we developed a virtual space where data in medical words and those of actual CKD patients were unified by natural …
View article: Aging effects on osteoclast progenitor dynamics affect variability in bone turnover via feedback regulation
Aging effects on osteoclast progenitor dynamics affect variability in bone turnover via feedback regulation Open
Bone turnover markers (BTMs) are commonly used in osteoporosis treatment as indicators of cell activities of bone-resorbing osteoclasts and bone-forming osteoblasts. The wide variability in their values due to multiple factors, such as agi…
View article: Sclerostin modulates the degree of mineralization and the stiffness profile of the fibrocartilaginous enthesis for mechanical tissue integrity
Sclerostin modulates the degree of mineralization and the stiffness profile of the fibrocartilaginous enthesis for mechanical tissue integrity Open
Fibrocartilaginous entheses consist of four graded tissue layers including tendon, the unmineralized and mineralized fibrocartilage, and subchondral bone with varying degrees of stiffness. Here we examined the functional role of sclerostin…
View article: Featured Cover
Featured Cover Open
Cover legend: The cover image is based on the Research Article Age‐associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex by Tanita Frey et al., https://doi.org/10.1111/acel.13925 [Image: see text]
View article: Profiling to Probing: Atomic force microscopy to characterize nano-engineered implants
Profiling to Probing: Atomic force microscopy to characterize nano-engineered implants Open
Surface modification of implants in the nanoscale or implant nano-engineering has been recognized as a strategy for augmenting implant bioactivity and achieving long-term implant success. Characterizing and optimizing implant characteristi…
View article: Age‐associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex
Age‐associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex Open
Neurons decline in their functionality over time, and age‐related neuronal alterations are associated with phenotypes of neurodegenerative diseases. In nonneural tissues, an infolded nuclear shape has been proposed as a hallmark of aged ce…
View article: Directionality of developing skeletal muscles is set by mechanical forces
Directionality of developing skeletal muscles is set by mechanical forces Open
View article: Development of continuum-based particle models of cell growth and proliferation for simulating tissue morphogenesis
Development of continuum-based particle models of cell growth and proliferation for simulating tissue morphogenesis Open
Biological tissues acquire various characteristic shapes through morphogenesis. Tissue shapes result from the spatiotemporally heterogeneous cellular activities influenced by mechanical and biochemical environments. To investigate multicel…
View article: 3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes
3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes Open
Although the formation of bone-like nodules is regarded as the differentiation process from stem cells to osteogenic cells, including osteoblasts and osteocytes, the precise biological events during nodule formation are unknown. Here we pe…
View article: Migrating neurons adapt motility modes to brain microenvironments via a mechanosensor, PIEZO1
Migrating neurons adapt motility modes to brain microenvironments via a mechanosensor, PIEZO1 Open
Migration of newborn neurons is essential for brain morphogenesis and circuit formation, yet controversy exists regarding how neurons generate the driving force against strong mechanical stresses in crowded neural tissues. We found that ce…