Takashi Amiya
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View article: Two New Diterpenoid Alkaloids from Delphinium pacific giant and Revised 13C-Nmr Assignment of Delpheline
Two New Diterpenoid Alkaloids from Delphinium pacific giant and Revised 13C-Nmr Assignment of Delpheline Open
Two new Clg-diterpenoid alkaloids, paciline (1) and pacinine (Z), and a known alkaloid, delpheline (1) were isolated from Delphinium pacific giant.Structures of those alkaloids were determined on the basis of their spectral data and chemic…
View article: Studies on Aconitum Species. XI. Two New Diterpenoid Alkaloids from Aconitum yesoense var. Macroyesoense (Nakai) Tamura V
Studies on Aconitum Species. XI. Two New Diterpenoid Alkaloids from Aconitum yesoense var. Macroyesoense (Nakai) Tamura V Open
A new Cz0-diterpenoid alkaloid, yesonine (11, a new Clg-diterpenoid alkaloid, U-oxobrowniine (21, and five known alkaloids were lsolated from Aconitum yesoense v a r .macroyesoense (Nakal) Tamura.Structures of those
View article: Studies on Aconitum Species VI1. Yesoline, a new C20-Diterpenoid Alkaloid from Aconitum Yesoense Var. Macroyesoense (Nakai) Tamura
Studies on Aconitum Species VI1. Yesoline, a new C20-Diterpenoid Alkaloid from Aconitum Yesoense Var. Macroyesoense (Nakai) Tamura Open
A new C20-diterpenoid alkaloid, yesoline, and a known alkaloid, 14-dehydrodeloosine were isolated from Aconitum yesoense ver.mecroyeeoense (Nakai) Tamura.Structure of the new alkaloid was determined by means of spectral and chemical meLhod…
View article: Studies on the Constituents of Aconitum Species. VII. On the Components of Aconitum Japonicum Thunb
Studies on the Constituents of Aconitum Species. VII. On the Components of Aconitum Japonicum Thunb Open
TWOnew diterpenoid alkaloids, subcumine I and subcosine ( ? ) , were ~solated from the roots of Aconitum japonicum Thunb.The structures of these alkaloids were determined on the basis of spectral data, chemical evidence, and X-ray analysis…
View article: Structures of secojesaconitine and subdesculine, two new diterpenoid alkaloids from Aconitum japonicum THUNB.
Structures of secojesaconitine and subdesculine, two new diterpenoid alkaloids from Aconitum japonicum THUNB. Open
The structures of two new diterpenoid alkaloids, secojesaconitine (1__∼) and subdesculine (5__∼), from (Aconitum)___- (japonicum)___- Thunb. were determined on the basis of spectral and chemical evidence. The structure of an unusual epoxid…
View article: Studies on Aconitum Species V. Constituents of Aconitum yesoense var. macroyesoense (Nakai) Tamura
Studies on Aconitum Species V. Constituents of Aconitum yesoense var. macroyesoense (Nakai) Tamura Open
Five new CZO-diterpenoid alkaloids, 12-acetyldehydro-Iucidusculine, 12-acetyllucidusculine. 15-benzoylpseudakobu8ine. 1 5 -v e r a t r o y i p s e o d o k o b ~~i n e , and Yesoxine and 14 known alkaloids were isolated from A. yesoense v a…
View article: Structure of a porcine spleen low-molecular-weight inhibitor of in vitro colony formation by bone marrow cells.
Structure of a porcine spleen low-molecular-weight inhibitor of in vitro colony formation by bone marrow cells. Open
The structure of a granulocyte-macrophage colony-inhibitory factor, which was isolated from porcine spleen, was identified as O-phosphoethanolamine by means of 1H- and 13C-nuclear magnetic resonance, infrared and mass spectroscopic analyse…
View article: Studies on the constituents of Aconitum species. III. On the components of Aconitum subcuneatum NAKAI.
Studies on the constituents of Aconitum species. III. On the components of Aconitum subcuneatum NAKAI. Open
A new alkaloid, 14-benzoylneoline, and four known alkaloids, neoline, karakoline, 14-acetyldelcosine, and penduline, were isolated from the roots of Aconitum subcuneatum NAKAI. The structures of 14-benzoylneoline and penduline were confirm…
View article: Studies on the constituents of aconitum species. IV. On the components of Aconitum japonicum THUNB.
Studies on the constituents of aconitum species. IV. On the components of Aconitum japonicum THUNB. Open
Two new alkaloids, aljesaconitine A and aljesaconitine B, and six known alkaloids, aconitine, jesaconitine, mesaconitine, neoline, hokbusine A, and delcosine, were isolated from the roots of Aconitum japonicum THUNB. (formerly known as Aco…
View article: Two New C20-Diterpenoid Alkaloids from Aconitum yesoense var. macroyesoense (Nakai) Tamura, Structures of Dehydrolucidusculine and N-Deethyldehydrolucidusculine
Two New C20-Diterpenoid Alkaloids from Aconitum yesoense var. macroyesoense (Nakai) Tamura, Structures of Dehydrolucidusculine and N-Deethyldehydrolucidusculine Open
Two new CZO-diterpenoid alkaloids, dehydrolucidusculine and N -d e e t h y l d e h y d r o l u c i d u s c u l i n e , and four known alkaloids, kobusine, pseudo-kobusine, delcosine, and 14-acetyldelcosine, were isolated from roots of Acon…
View article: Studies on the constituents of Aconitum species. II. Structure of deoxyjesaconitine.
Studies on the constituents of Aconitum species. II. Structure of deoxyjesaconitine. Open
A new diterpene alkaloid, deoxyjesaconitine, was isolated from the rhizoma of Aconitum subcuneatum NAKAI (Ranunculaceae) and its structure was established by analysis of the spectral data and by conversion of jesaconitine into deoxyjesacon…
View article: The transformation of mesaconitine to isodelphinine: Deoxygenation of bridgehead hydroxyl.
The transformation of mesaconitine to isodelphinine: Deoxygenation of bridgehead hydroxyl. Open
A trifluoromethanesulfonate of anhydromesaconitine was subjected to photochemical reaction, which contains replacement of the bridgehead hydroxyl at C (13) by hydrogen, followed by catalytic hydrogenation, yielding isodelphinine.
View article: Studies on the constituents of the crude drug "Piperis Longi Fructus." On the alkaloids of fruits of Piper longum L.
Studies on the constituents of the crude drug "Piperis Longi Fructus." On the alkaloids of fruits of Piper longum L. Open
Two new piperidine alkaloids, pipernonaline and piperundecalidine, were isolated from fruits of Piper longum L. (Piperaceae). Their structures were determined to be (2E, 8E)-N-[9-(3, 4-methylenedioxyphenyl)-2, 8-nonadienoyl]piperidine and …
View article: A simple synthesis of methyl ethers of tribromophenols from the red alga Symphyocladia latiuscla.
A simple synthesis of methyl ethers of tribromophenols from the red alga Symphyocladia latiuscla. Open
Bis (2, 3, 6-tibromo-4, 5-dimethoxybenzyl) ether (IV), 2, 3, 6-tribromo-4, 5-dimethoxybenzyl methyl ether (V), 2, 3, 6-tribromo-4, 5-dimethoxybenzyl ethyl ether (VI) and 2, 3, 6-tribromo-4, 5-dimethoxybenzyl alcohol (VIII) were prepared by…
View article: Studies on the Indonesian Antiaris toxicaria sap.
Studies on the Indonesian Antiaris toxicaria sap. Open
The present research is on a milky sap obtained from the Antiaris toxicaria tree (Moraceae) which is called Upas or Ipoh in Indonesia. The crude sap was administered to anesthetized rats, and changes in electrocardiogram (ECG) and systemic…
View article: Synthesis of 4,4-dimethyl-2-nitro-5.ALPHA.-cholest-1-en-3-one.
Synthesis of 4,4-dimethyl-2-nitro-5.ALPHA.-cholest-1-en-3-one. Open
Treatment of 4, 4-dimethyl-5α-cholest-1-en-3-one with nitric acid gave 4, 4-dimethyl-2-nitro-5α-cholest-1-en-3-one. A possible mechanism for the nitration is proposed.
View article: The Structure of Nitronitrosoaconitinic Acid, the Oxidation Product of Aconitine with Nitric Acid
The Structure of Nitronitrosoaconitinic Acid, the Oxidation Product of Aconitine with Nitric Acid Open
The structure of nitronitrosoaconitinic acid, which is an oxidation product of aconitine with nitric acid, was confirmed by spectroscopic methods. This compound is a new type of acid, a 2-nitro-2-cyclohexen-1-one, with a pKa value comparab…
View article: Studies on the constituents of asclepidaceae plants. XLVIII. 5.ALPHA.,6.ALPHA.-Epoxycaudatin, a new polyoxypregnane derivative from Cynanchum caudatum Max.
Studies on the constituents of asclepidaceae plants. XLVIII. 5.ALPHA.,6.ALPHA.-Epoxycaudatin, a new polyoxypregnane derivative from Cynanchum caudatum Max. Open
A new polyoxypregnane derivative, 5α, 6α-epoxycaudatin, was isolated from Cynanchum caudatum MAX. and its structure was elucidated on the bases of physical data and chemical reaction. This compound is a probable intermcdiate in the biosynt…
View article: Studies on the constituents of asclepiadaceae plants. XLVII. Acyl migration of polyoxypregnane derivatives.
Studies on the constituents of asclepiadaceae plants. XLVII. Acyl migration of polyoxypregnane derivatives. Open
A chemical acyl migration equilibrium between 12β-hydroxyl and 20-hydroxyl groups was found to depend on the C-17 and C-20 configurations in C/D-cis-polyoxypregnane derivatives. In the case of 20S derivatives with a 17α-side chain, the equ…
View article: Some Derivatives of Anhydrodiacetyldelcosine (Anhydrodiacetyllucaconine)
Some Derivatives of Anhydrodiacetyldelcosine (Anhydrodiacetyllucaconine) Open
On the basis of the structure of delcosine (lucaconine), a diterpene alkaloid, the structures of anhydrodiacetyldelcosine and dihydroanhydrodiacetyldelcosine have previously been established. Some reactions of these compounds and their der…
View article: 3-Hydroxy-2-naphthoates of lidocaine, mepivacaine, and bupivacaine and their dissolution characteristics.
3-Hydroxy-2-naphthoates of lidocaine, mepivacaine, and bupivacaine and their dissolution characteristics. Open
3-Hydroxy-2-naphthoates of lidocaine (I), mepivacine (II), and bupivacaine (III) were prepared as a potential means of prolonging the action of these local anesthetic amines through their sparingly soluble salt forms. The molar ratio of th…
View article: Studies on the Constituents of a Red Marine Alga, Odonthalia corymbifera
Studies on the Constituents of a Red Marine Alga, Odonthalia corymbifera Open
Eight crystalline substances were isolated from a methanol extract of the red marine alga, Odonthalia corymbifera, and investigated by ultraviolet absorption, infrared spectros-copy, nuclear magnetic resonance, mass spectrometry and chemic…
View article: The Aconite Alkaloids. XXXV. On Lucidusculine. V
The Aconite Alkaloids. XXXV. On Lucidusculine. V Open
Luciculine (II) was isomerized to a ketone base, isoluciculine (III), and this fact shows the presence of an allyl alcohol system in the structure of compound II. The previous report concerning bromoanhydrolucidusculine hydrobromide (IV) w…
View article: The Aconite Alkaloids, XXXIII. On Lucidusculine. III
The Aconite Alkaloids, XXXIII. On Lucidusculine. III Open
The alkaloid lucidusculine was oxidized by hydrogen peroxide and also by perbenzoic acid to lucidusculine N-oxide. The N-oxide could be converted back into the original base by reduction. Oxidation of the alkaloid with N-bromosuccinimide a…