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View article: Effect of Sacubitril/Valsartan, Ivabradine, and Captopril on Anxiety-like Behavior in Spontaneously Hypertensive Rats
Effect of Sacubitril/Valsartan, Ivabradine, and Captopril on Anxiety-like Behavior in Spontaneously Hypertensive Rats Open
Cardiovascular disorders and the medications used to treat them can affect physiological patterns of behavior. The aim of the present study was to determine whether the dual inhibition of neprilysin and angiotensin II—sacubitril/valsartan …
View article: Biological Indicators of Cardiovascular Health by Foster Care History in Adults
Biological Indicators of Cardiovascular Health by Foster Care History in Adults Open
Childhood foster care placement is associated with poorer cardiovascular health, particularly hypertension, even in groups generally at lower risk. Research and clinical initiatives are needed to better understand and address cardiovascula…
View article: Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model
Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model Open
Background and Aims Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and impaired metabolic efficiency. This study investigates the therapeutic pote…
View article: SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice
SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice Open
View article: Considering chronotype to improve hypertension management
Considering chronotype to improve hypertension management Open
View article: Pharmacological stimulation of the parasympathetic system – a promising means of cardioprotection in heart failure
Pharmacological stimulation of the parasympathetic system – a promising means of cardioprotection in heart failure Open
View article: Sacubitril/Valsartan Alleviates Cardiac Remodeling and Dysfunction in L-NAME-Induced Hypertension and Hypertensive Heart Disease
Sacubitril/Valsartan Alleviates Cardiac Remodeling and Dysfunction in L-NAME-Induced Hypertension and Hypertensive Heart Disease Open
There is ample evidence on the benefit of angiotensin receptor-neprilysin inhibitors (ARNIs) in heart failure, yet data regarding the potential protective action of ARNIs in hypertensive heart disease are sparse. The aim of this study was …
View article: Effect of sacubitril/valsartan on the hypertensive heart in continuous light-induced and lactacystin-induced pre-hypertension: Interactions with the renin-angiotensin-aldosterone system
Effect of sacubitril/valsartan on the hypertensive heart in continuous light-induced and lactacystin-induced pre-hypertension: Interactions with the renin-angiotensin-aldosterone system Open
This study investigated whether sacubitril/valsartan or valsartan are able to prevent left ventricular (LV) fibrotic remodelling and dysfunction in two experimental models of pre-hypertension induced by continuous light (24 hours/day) expo…
View article: The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760
The effect of zofenopril on the cardiovascular system of spontaneously hypertensive rats treated with the ACE2 inhibitor MLN-4760 Open
View article: SGLT2 inhibitor ertugliflozin decreases elevated intracellular sodium, and improves energetics and contractile function in diabetic cardiomyopathy
SGLT2 inhibitor ertugliflozin decreases elevated intracellular sodium, and improves energetics and contractile function in diabetic cardiomyopathy Open
Elevated myocardial [Na+]i contributes to mitochondrial and contractile dysfunction in DCMP. Targeting myocardial [Na+]i and/or NCXMITO may be an effective strategy in DCMP and other f…
View article: Ivabradine curbs isoproterenol-induced kidney fibrosis
Ivabradine curbs isoproterenol-induced kidney fibrosis Open
This study investigated whether chronic isoproterenol administration could induce kidney alterations and whether ivabradine, a heart rate (HR)-reducing substance exerting cardiovascular protection, is able to attenuate potential kidney dam…
View article: Melatonin as a Potential Approach to Anxiety Treatment
Melatonin as a Potential Approach to Anxiety Treatment Open
Anxiety disorders are the most common mental diseases. Anxiety and the associated physical symptoms may disturb social and occupational life and increase the risk of somatic diseases. The pathophysiology of anxiety development is complex a…
View article: Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril
Lactacystin-induced kidney fibrosis: Protection by melatonin and captopril Open
Lactacystin is a specific proteasome inhibitor that blocks the hydrolysis of intracellular proteins by ubiquitin/proteasome system inhibition. The administration of lactacystin to rats induced hypertension and remodeling of the left ventri…
View article: Sacubitril/Valsartan and Ivabradine Attenuate Left Ventricular Remodelling and Dysfunction in Spontaneously Hypertensive Rats: Different Interactions with the Renin–Angiotensin–Aldosterone System
Sacubitril/Valsartan and Ivabradine Attenuate Left Ventricular Remodelling and Dysfunction in Spontaneously Hypertensive Rats: Different Interactions with the Renin–Angiotensin–Aldosterone System Open
This study investigated whether sacubitril/valsartan and ivabradine are able to prevent left ventricular (LV) fibrotic remodelling and dysfunction in a rat experimental model of spontaneous hypertension (spontaneously hypertensive rats, SH…
View article: Highlights From the <i>Circulation</i> Family of Journals
Highlights From the <i>Circulation</i> Family of Journals Open
The highlights from the March subspecialty journals cover several fascinating topics.An open-label dose escalation study of oral inhaled flecainide solution for cardioversion of atrial fibrillation is described in Circulation Arrhythmia an…
View article: Commentary: Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells
Commentary: Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells Open
GENERAL COMMENTARY article Front. Pharmacol., 28 January 2022Sec. Translational Pharmacology Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.842512
View article: Chronotherapy of cardiovascular pathologies: a hopeful strategy
Chronotherapy of cardiovascular pathologies: a hopeful strategy Open
View article: Monitoring Non-dipping Heart Rate by Consumer-Grade Wrist-Worn Devices: An Avenue for Cardiovascular Risk Assessment in Hypertension
Monitoring Non-dipping Heart Rate by Consumer-Grade Wrist-Worn Devices: An Avenue for Cardiovascular Risk Assessment in Hypertension Open
OPINION article Front. Cardiovasc. Med., 23 July 2021 | https://doi.org/10.3389/fcvm.2021.711417
View article: Hypertension chronotherapy: does dosing antihypertensive medication at bedtime determine cardiovascular prognosis?
Hypertension chronotherapy: does dosing antihypertensive medication at bedtime determine cardiovascular prognosis? Open
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View article: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat? Open
Angiotensin-converting enzyme 2 (ACE2) is the leading player of the protective renin–angiotensin system (RAS) pathway but also the entry receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). RAS inhibitors seemed to in…
View article: Ivabradine and Blood Pressure Reduction: Underlying Pleiotropic Mechanisms and Clinical Implications
Ivabradine and Blood Pressure Reduction: Underlying Pleiotropic Mechanisms and Clinical Implications Open
OPINION article Front. Cardiovasc. Med., 10 February 2021 | https://doi.org/10.3389/fcvm.2021.607998
View article: Duálna inhibícia neprilyzínu a receptora typu 1 pre angiotenzín II vo svetle klinických štúdií / Dual inhibition of neprilysin and angiotensin II type 1 receptor in light of clinical studies
Duálna inhibícia neprilyzínu a receptora typu 1 pre angiotenzín II vo svetle klinických štúdií / Dual inhibition of neprilysin and angiotensin II type 1 receptor in light of clinical studies Open
Despite advances in heart failure (HF) pharmacotherapy over the last three decades, the residual mortality with HF remains high.The antipode to the drug-induced inhibition of vasoconstrictive and proliferative substances could be an increa…
View article: Ivabradine improves survival and attenuates cardiac remodeling in isoproterenol‐induced myocardial injury
Ivabradine improves survival and attenuates cardiac remodeling in isoproterenol‐induced myocardial injury Open
This study investigated whether ivabradine, a selective I f current inhibitor reducing heart rate (HR), is able to improve survival and prevent left ventricular (LV) remodeling in isoproterenol‐induced heart damage. Wistar rats were treate…
View article: Ivabradine Ameliorates Kidney Fibrosis in L-NAME-Induced Hypertension
Ivabradine Ameliorates Kidney Fibrosis in L-NAME-Induced Hypertension Open
Hypertension-induced renal injury is characterized by structural kidney alterations and function deterioration. Therapeutics for kidney protection are limited, thus novel renoprotectives in hypertension are being continuously sought out. I…
View article: Increasing mitochondrial ATP synthesis with butyrate normalizes ADP and contractile function in metabolic heart disease
Increasing mitochondrial ATP synthesis with butyrate normalizes ADP and contractile function in metabolic heart disease Open
Metabolic heart disease (MHD), which is strongly associated with heart failure with preserved ejection fraction, is characterized by reduced mitochondrial energy production and contractile performance. In this study, we tested the hypothes…
View article: Genetically targeted fluorescent probes reveal dynamic calcium responses to adrenergic signaling in multiple cardiomyocyte compartments
Genetically targeted fluorescent probes reveal dynamic calcium responses to adrenergic signaling in multiple cardiomyocyte compartments Open
View article: Chronotherapy as a potential approach to hypertensive patients with elevated heart rate?
Chronotherapy as a potential approach to hypertensive patients with elevated heart rate? Open
Chronotherapy is a therapeutic approach that respects the circadian variations of physiological processes. The chronotherapeutic approach to hypertension has been shown to improve blood pressure (BP) control and reduce cardiovascular event…
View article: Lisinopril reverses behavioural alterations in spontaneously hypertensive rats
Lisinopril reverses behavioural alterations in spontaneously hypertensive rats Open
This study investigated the effect of lisinopril (angiotensin-converting enzyme inhibitor) on potential behavioural alterations in spontaneously hypertensive rats (SHR). Three groups of 15-17-week-old rats were investigated for 2 weeks: Wi…
View article: Ivabradine does not Impair Anxiety-Like Behavior and Memory in Both Healthy and L-NAME-Induced Hypertensive Rats
Ivabradine does not Impair Anxiety-Like Behavior and Memory in Both Healthy and L-NAME-Induced Hypertensive Rats Open
Cardiovascular pathologies are frequently associated with anxiety and other behavioral disturbances. Ivabradine, an inhibitor of the hyperpolarization-activated cyclic nucleotide-gated channels in the sinoatrial node, decreases heart rate …
View article: Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension
Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension Open
Ivabradine, the selective inhibitor of the If current in the sinoatrial node, exerts cardiovascular protection by its bradycardic effect and potentially pleiotropic actions. However, there is a shortage of data regarding ivabradine’s inter…