Michael T. Barbe
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View article: Differential gait disturbances in patients with Parkinson's disease and normal pressure hydrocephalus
Differential gait disturbances in patients with Parkinson's disease and normal pressure hydrocephalus Open
Except for static postural control (i.e., balance), instrument-supported gait analysis revealed several characteristic gait differences between PD and NPH patients. Variability and rhythm, reflecting gait regularity, were best suited to di…
View article: Executive dysfunctions impair and levodopa improves articulatory timing in Parkinson‘s disease
Executive dysfunctions impair and levodopa improves articulatory timing in Parkinson‘s disease Open
This study investigates the effects of executive functions and levodopa on articulatory timing patterns in simple and complex syllable onsets (CV vs. CCV) in Parkinson’s disease (PD). Kinematic speech data (EMA) of 25 individuals with PD i…
View article: Deep Brain Stimulation for <scp> <i>VPS16</i> </scp> ‐Related Dystonia: A Multicenter Study
Deep Brain Stimulation for <span> <i>VPS16</i> </span> ‐Related Dystonia: A Multicenter Study Open
Objective The objective was to evaluate the effects of deep brain stimulation (DBS) in an international cohort of patients with VPS16 ‐related dystonia. Methods This observational study collected preoperative and postoperative demographic,…
View article: Structural Connectivity of the Basal Ganglia from Patient-Individual Tractography Is Key for Understanding the Effects of Deep Brain Stimulation in Parkinson’s Disease
Structural Connectivity of the Basal Ganglia from Patient-Individual Tractography Is Key for Understanding the Effects of Deep Brain Stimulation in Parkinson’s Disease Open
Introduction: In Parkinson’s disease (PD) patients, modulation of the fibre tracts of the cortico-basal ganglia-thalamo-cortical loop is the presumed mechanism of action of deep brain stimulation (DBS) of the subthalamic nucleus (STN). The…
View article: Tractography-guided versus Clinical Contact Selection for Deep Brain Stimulation in Tremor - A Prospective Clinical Trial
Tractography-guided versus Clinical Contact Selection for Deep Brain Stimulation in Tremor - A Prospective Clinical Trial Open
Background Imaging-guided programming strategies for deep brain stimulation (DBS) offer the potential to reduce programming time and complexity. However, evidence-based paradigms tailored to tremor remain unavailable. Converging research p…
View article: Automatic speech analysis combined with machine learning reliably predicts the motor state in people with Parkinson’s disease
Automatic speech analysis combined with machine learning reliably predicts the motor state in people with Parkinson’s disease Open
It is still under debate whether levodopa treatment improves speech functions in Parkinson’s disease (PD). Therefore, speech functions of people with PD were compared in medication-OFF condition (withdrawal of PD medication for at least 12…
View article: Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated <scp>REM</scp> Sleep Behavior Disorder and Parkinson's Disease
Elevated α‐Synuclein Aggregate Levels in the Urine of Patients with Isolated <span>REM</span> Sleep Behavior Disorder and Parkinson's Disease Open
Parkinson's disease (PD) is a neurodegenerative disorder characterized by α‐synuclein aggregation in neurons. Recent advances suggest α‐synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used s…
View article: Antero‐Lateral Subthalamic Nucleus Theta Stimulation Improves Verbal Fluency in Parkinson's Disease
Antero‐Lateral Subthalamic Nucleus Theta Stimulation Improves Verbal Fluency in Parkinson's Disease Open
Objective Low‐frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been associated with positive effects on verbal fluency (VF) in patients with Parkinson's disease. This prospective study investigates stimulation di…
View article: Subthalamic Deep Brain Stimulation: Mapping Non‐Motor Outcomes to Structural Connections
Subthalamic Deep Brain Stimulation: Mapping Non‐Motor Outcomes to Structural Connections Open
In Parkinson's Disease (PD), deep brain stimulation of the subthalamic nucleus (STN‐DBS) reliably improves motor symptoms, and the circuits mediating these effects have largely been identified. However, non‐motor outcomes are more variable…
View article: Computerized cognitive training to strengthen cognitive and non-cognitive outcomes in people with advanced Parkinson’s disease compared to care as usual (TrainParC-Advanced): study protocol of a randomized controlled trial
Computerized cognitive training to strengthen cognitive and non-cognitive outcomes in people with advanced Parkinson’s disease compared to care as usual (TrainParC-Advanced): study protocol of a randomized controlled trial Open
Background: Cognitive impairment is common in Parkinson’s disease (PD). Up to 80% of people with PD develop dementia over the disease course, heavily impacting their quality of life. While pharmacological treatment options are scarce, prev…
View article: Elevated α-synuclein aggregate levels in the urine of patients with isolated REM sleep behavior disorder and Parkinson’s disease
Elevated α-synuclein aggregate levels in the urine of patients with isolated REM sleep behavior disorder and Parkinson’s disease Open
Parkinson’s disease is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for Parkinson’s disease and related synucleinopathies. This …
View article: Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome
Alterations of sensorimotor predictive processes and their electrophysiological signatures in Tourette syndrome Open
People with Tourette syndrome exhibit excessive motor actions known as tics. An aversive sensation called the premonitory urge often precedes these tics, leading to the conceptualization of Tourette syndrome as a sensorimotor disorder. In …
View article: A critical role of action-related functional networks in Gilles de la Tourette syndrome
A critical role of action-related functional networks in Gilles de la Tourette syndrome Open
Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing tic severity, optimal target networks are not well-defin…
View article: Corrigendum: An automatic measure for speech intelligibility in dysarthrias—validation across multiple languages and neurological disorders
Corrigendum: An automatic measure for speech intelligibility in dysarthrias—validation across multiple languages and neurological disorders Open
[This corrects the article DOI: 10.3389/fdgth.2024.1440986.].
View article: Elevated Aβ aggregates in feces from Alzheimer’s disease patients: a proof-of-concept study
Elevated Aβ aggregates in feces from Alzheimer’s disease patients: a proof-of-concept study Open
Background Misfolding and aggregation of amyloid β (Aβ), along with neurofibrillary tangles consisting of aggregated Tau species, are pathological hallmarks of Alzheimer’s disease (AD) onset and progression. In this study, we hypothesized …
View article: Validation Study of the Parkinson’s Disease Stigma Questionnaire (PDStigmaQuest)
Validation Study of the Parkinson’s Disease Stigma Questionnaire (PDStigmaQuest) Open
Background: Stigma is a relevant aspect of Parkinson’s disease (PD). Specific stigma tools are needed to address the complex construct of stigma in PD comprehensively. Objective: To test the dimensionality and psychometric properties of th…
View article: Video-Guided Optimization of Stimulation Settings in Patients with Parkinson’s Disease and Deep Brain Stimulation
Video-Guided Optimization of Stimulation Settings in Patients with Parkinson’s Disease and Deep Brain Stimulation Open
Deep brain stimulation (DBS) for Parkinson’s disease (PD) often necessitates frequent clinic visits for stimulation program optimization, with limited experience in remote patient management. Due to the resource-intensive nature of these p…
View article: Prosody matters: Preserved prominence marking strategies in people with Parkinson’s disease independent of motor status
Prosody matters: Preserved prominence marking strategies in people with Parkinson’s disease independent of motor status Open
While many studies focus on segmental variation in Parkinsonian speech, little is known about prosodic modulations reflecting the ability to adapt to communicative demands in people with Parkinson’s disease (PwPD). This type of prosodic mo…
View article: An automatic measure for speech intelligibility in dysarthrias—validation across multiple languages and neurological disorders
An automatic measure for speech intelligibility in dysarthrias—validation across multiple languages and neurological disorders Open
Introduction Dysarthria, a motor speech disorder caused by muscle weakness or paralysis, severely impacts speech intelligibility and quality of life. The condition is prevalent in motor speech disorders such as Parkinson's disease (PD), at…
View article: Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions
Progressive Supranuclear Palsy: Subcortical Tau Depositions Are Associated with Cortical Perfusion in Frontal and Limbic Regions Open
In progressive supranuclear palsy (PSP), subcortical tau and cortical perfusion can be assessed using the tracer [ 18 F]PI-2620. We investigated if subcortical tau (globus pallidus internus, dentate nucleus) and frontal/limbic perfusion co…
View article: Deep brain stimulation of symptom-specific networks in Parkinson’s disease
Deep brain stimulation of symptom-specific networks in Parkinson’s disease Open
Deep Brain Stimulation can improve tremor, bradykinesia, rigidity, and axial symptoms in patients with Parkinson’s disease. Potentially, improving each symptom may require stimulation of different white matter tracts. Here, we study a larg…
View article: Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [<sup>18</sup>F]PI-2620
Improved Tau PET SUVR Quantification in 4-Repeat Tau Phenotypes with [<sup>18</sup>F]PI-2620 Open
We used a new data-driven methodology to identify a set of reference regions that enhanced the quantification of the SUV ratio of the second-generation tau tracer 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-…