Bruce Thompson
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View article: EXPRESS: Concurrent Caudal Cruciate and Medial Collateral Ligament Repair using a Single Mini TightRope™ (Arthrex) Fixation in a Cat
EXPRESS: Concurrent Caudal Cruciate and Medial Collateral Ligament Repair using a Single Mini TightRope™ (Arthrex) Fixation in a Cat Open
Case Summary A two year-old female spayed domestic shorthaired cat presented with acute left pelvic limb lameness following suspected trauma. Orthopaedic and radiographic findings were consistent with a medial collateral and caudal cruciat…
View article: Grid cell distortion is associated with increased distance estimation error in polarized environments
Grid cell distortion is associated with increased distance estimation error in polarized environments Open
Grid cells within the medial entorhinal cortex (MEC) exhibit a regular hexagonal pattern of firing fields,1 which has been hypothesized to provide a universal spatial metric, supporting spatial memory and navigation. This could be used to …
View article: Polarimeter to Unify the Corona and Heliosphere (PUNCH)
Polarimeter to Unify the Corona and Heliosphere (PUNCH) Open
The Polarimeter to Unify the Corona and Heliosphere (PUNCH) mission is a NASA Small Explorer to determine the cross-scale processes that unify the solar corona and heliosphere. PUNCH has two science objectives: (1) understand how coronal s…
View article: Interpreting respiratory oscillometry in adults with asthma or COPD: findings of an international Delphi study
Interpreting respiratory oscillometry in adults with asthma or COPD: findings of an international Delphi study Open
Background Respiratory oscillometry measures the physiological effort and mechanics of moving air in and out of the lungs during normal breathing. It provides complementary information to spirometry. Uncertainty regarding the interpretatio…
View article: Assessment of ventilation heterogeneity in severe asthma using phase‐resolved functional lung magnetic resonance imaging
Assessment of ventilation heterogeneity in severe asthma using phase‐resolved functional lung magnetic resonance imaging Open
Ventilation heterogeneity is a hallmark of asthma. This study examines the feasibility of phase‐resolved functional lung magnetic resonance imaging (PREFUL MRI) in the evaluation of ventilation heterogeneity in severe asthma, its response …
View article: Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial
Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial Open
Introduction Targeted oxygenation protocols in mechanically ventilated patients are critical in avoiding the deleterious effects of hypoxaemia and hyperoxaemia. Peripheral oxygen saturation (SpO2) is a practical metric that commonly drives…
View article: POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: The significance of functional adrenal hyperandrogenism in polycystic ovary syndrome across the lifespan
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: The significance of functional adrenal hyperandrogenism in polycystic ovary syndrome across the lifespan Open
In brief The adrenal glands are an additional source of hyperandrogenemia in a significant proportion of women with polycystic ovary syndrome (PCOS). This review presents the evidence for the role of adrenal hyperandrogenism in the develop…
View article: Genomics-based approach for detection and characterization of SARS-CoV-2 co-infections and diverse viral populations
Genomics-based approach for detection and characterization of SARS-CoV-2 co-infections and diverse viral populations Open
Due to the continuous genetic diversification of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) over time, the co-circulation of two different lineages in the same region may lead to co-infections within a host, a situat…
View article: Associations Between Occupational Exposures and Cough Subclasses Among Middle‐Aged Australians
Associations Between Occupational Exposures and Cough Subclasses Among Middle‐Aged Australians Open
Background and Objective The evidence around occupation‐related chronic cough is conflicting and current definitions of chronic cough cannot capture its heterogeneity. Using our recently characterised novel cough subclasses, we aimed to id…
View article: SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial)
SARS-Cov-2 vaccination strategies in hospitalized recovered COVID-19 patients: a randomized clinical trial (VATICO Trial) Open
The impact on immunogenicity and efficacy of SARS-CoV-2 vaccination in people with prior COVID-19 could differ depending on timing of vaccination and number of doses. The VATICO study randomized 66 hospitalized recovered COVID-19 individua…
View article: Early‐to‐Midlife Body Mass Index Trajectories and Obstructive Sleep Apnoea Risk 10 Years Later
Early‐to‐Midlife Body Mass Index Trajectories and Obstructive Sleep Apnoea Risk 10 Years Later Open
Background and Objective While short‐term weight changes are known to influence obstructive sleep apnoea (OSA), the impact of body mass index (BMI) changes over the life course has been poorly documented. We examined the association betwee…
View article: NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome
NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome Open
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway obstruction and inflammation. Non-typeable Haemophilus influenzae (NTHi) lung infections are common in COPD, promoting frequent exacerbations an…
View article: Lifetime Body Mass Index Trajectories and Contrasting Lung Function Abnormalities in Mid‐Adulthood: Data From the Tasmanian Longitudinal Health Study
Lifetime Body Mass Index Trajectories and Contrasting Lung Function Abnormalities in Mid‐Adulthood: Data From the Tasmanian Longitudinal Health Study Open
Background and Objective The impact of lifetime body mass index (BMI) trajectories on adult lung function abnormalities has not been investigated previously. We investigated associations of BMI trajectories from childhood to mid‐adulthood …
View article: Beyond bronchial thermoplasty – where to now?
Beyond bronchial thermoplasty – where to now? Open
With the impending 'retirement' of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primar…
View article: Lung function may recover after coal mine fire smoke exposure: a longitudinal cohort study
Lung function may recover after coal mine fire smoke exposure: a longitudinal cohort study Open
Background and objective The 2014 Hazelwood coal mine fire exposed residents in nearby Morwell to high concentrations of particulate matter <2.5 µm (PM 2.5 ) for approximately 6 weeks. This analysis aimed to evaluate the long-term impact o…
View article: Ventilation heterogeneity is increased in adults exposed to coal mine fire‐related PM <sub>2.5</sub>
Ventilation heterogeneity is increased in adults exposed to coal mine fire‐related PM <sub>2.5</sub> Open
Background and Objectives The Hazelwood Health Study was set up to study long‐term health effects of a mine fire that blanketed residents of the Latrobe Valley with smoke for 45 days in 2014. The Respiratory Stream specifically assessed th…
View article: Longitudinal Importance of the Soluble Receptor for Advanced Glycation End-Products in Non-intubated Hospitalized Patients with COVID-19 Pneumonia
Longitudinal Importance of the Soluble Receptor for Advanced Glycation End-Products in Non-intubated Hospitalized Patients with COVID-19 Pneumonia Open
The soluble receptor for advanced glycation end-products (sRAGE) is a marker of alveolar type I cell injury associated with outcomes COVID-19 pneumonia. How plasma sRAGE changes over time and whether it remains associated with long-term cl…
View article: Lung function may recover after coal mine fire smoke exposure: a longitudinal cohort study
Lung function may recover after coal mine fire smoke exposure: a longitudinal cohort study Open
Background and objective The 2014 Hazelwood coalmine fire exposed residents in nearby Morwell to high concentrations of particulate matter <2·5 µm (PM 2·5 ) for approximately 6 weeks. This analysis aimed to evaluate the long-term impact on…
View article: Childhood infections, asthma and allergy trajectories, and chronic rhinosinusitis in middle age: A prospective cohort study across six decades
Childhood infections, asthma and allergy trajectories, and chronic rhinosinusitis in middle age: A prospective cohort study across six decades Open
Introduction Evidence on the early life risk factors of adult CRS, and the history of asthma and allergies across the life course, is limited. Aim To investigate relationships between respiratory infective/allergic conditions in childhood,…
View article: Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis Open
Importance Acetaminophen (paracetamol) has many pharmacological effects that might be beneficial in sepsis, including inhibition of cell-free hemoglobin-induced oxidation of lipids and other substrates. Objective To determine whether aceta…
View article: Association between PM2.5 from a coal mine fire and eosinophilic airway inflammation 7.5 years later
Association between PM2.5 from a coal mine fire and eosinophilic airway inflammation 7.5 years later Open
Background and aim: There are few long-term studies of respiratory health effects of landscape fires, despite increasing frequency and intensity due to climate change. We investigated the association between exposure to coal mine fire PM 2…
View article: Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock
Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock Open
Introduction Sepsis is a highly morbid condition characterized by multi-organ dysfunction resulting from dysregulated inflammation in response to acute infection. Mitochondrial dysfunction may contribute to sepsis pathogenesis, but quantif…