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Changing Residue 338 in Human Factor IX from Arginine to Alanine Causes an Increase in Catalytic Activity Open
This study was designed to identify functionally important factor IX (FIX) residues. Using recombinant techniques and cell culture, we produced a mutant FIX with arginine at 338 changed to alanine (R338A-FIX). This molecule had approximate…
Structural basis for the Zn<sup>2+</sup> inhibition of the zymogen-like kallikrein-related peptidase 10 Open
Although kallikrein-related peptidase 10 (KLK10) is expressed in a variety of human tissues and body fluids, knowledge of its physiological functions is fragmentary. Similarly, the pathophysiology of KLK10 in cancer is not well understood.…