Jonathan T. Butcher
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View article: Cell-type Specific GTPase Regulation of Aortic Valve Homeostasis and CAVD Progression
Cell-type Specific GTPase Regulation of Aortic Valve Homeostasis and CAVD Progression Open
Calcific Aortic Valve Disease (CAVD) involves active remodeling of the thin fibrous leaflet matrix into large hypercellular and mineralized lesions, indicative of profound cellular interactions that have not been well explored. Herein, lon…
View article: KEYNOTE: Hemodynamic disruption in the proximal outflow tract generates complex congenital heart valve defects without genetic mutation
KEYNOTE: Hemodynamic disruption in the proximal outflow tract generates complex congenital heart valve defects without genetic mutation Open
Proper growth and division of the embryonic outflow tract (OFT) into balanced pulmonary and aortic outlets, complete with functioning semilunar valves is essential for robust delivery of oxygenated blood. Many clinically serious cardiac ma…
View article: Embedding Studio-Based Learning in the Biomedical Engineering Curriculum to Improve Quantitative Problem-Solving Skills
Embedding Studio-Based Learning in the Biomedical Engineering Curriculum to Improve Quantitative Problem-Solving Skills Open
Purpose We present a curriculum transformation initiative within the BME Department at Cornell University, focused on integrating studio-based pedagogy to enhance students’ technical and creative problem-solving abilities. We outline the s…
View article: Longitudinal Live Imaging Derived 4D Hemodynamics and Dynamic Tissue Mechanics Across Outflow Tract Morphogenesis
Longitudinal Live Imaging Derived 4D Hemodynamics and Dynamic Tissue Mechanics Across Outflow Tract Morphogenesis Open
Growth and remodeling of the cardiac outflow tract (OFT) is poorly understood but associated with serious congenital heart defects (CHD). While only a minority of CHDs have identifiable genetic causes, the functional roles of mechanical fo…
View article: Valve endothelial monolayer fissuring via RhoA activity induces 3D calcific aortic valve lesion emergence as revealed by a longitudinal live-imaging platform
Valve endothelial monolayer fissuring via RhoA activity induces 3D calcific aortic valve lesion emergence as revealed by a longitudinal live-imaging platform Open
Calcific aortic valve disease (CAVD) is a degenerative disease with wide prevalence in the aging population and a low survival rate after onset of symptoms, yet there are no effective pharmacological treatments. Many patients present to th…
View article: Computational Fluid Dynamic Optimization of Micropatterned Surfaces: Towards Biofunctionalization of Artificial Organs
Computational Fluid Dynamic Optimization of Micropatterned Surfaces: Towards Biofunctionalization of Artificial Organs Open
Modifying surface topography to prevent surface-induced thrombosis in cardiovascular implants allows endothelialization, which is the natural thrombo-resistance of blood-contacting surfaces, and is deemed to be the only long-term solution …
View article: Computational Fluid Dynamic Optimization of Micropatterned Surfaces: Towards Biofunctionalization of Artificial Organs
Computational Fluid Dynamic Optimization of Micropatterned Surfaces: Towards Biofunctionalization of Artificial Organs Open
Modifying surface topography to prevent surface-induced thrombosis in cardiovascular implants allows endothelialization, which is the natural thrombo-resistance of the blood-contacting surfaces and is deemed to be the only long-term hemoco…
View article: The Role of Matrix Stiffness and Viscosity on Lipid Phenotype and Fat Lineage Potential
The Role of Matrix Stiffness and Viscosity on Lipid Phenotype and Fat Lineage Potential Open
Autologous fat transfer is a common procedure that patients undergo to rejuvenate large soft tissue defects. However, these surgeries are complicated by limited tissue sources, donor-site morbidity, and necrosis. While the biofabrication o…
View article: Work in Progress: Evaluating the impact of student cognitive and emotional responses to real-time feedback on student engagement in engineering design studios
Work in Progress: Evaluating the impact of student cognitive and emotional responses to real-time feedback on student engagement in engineering design studios Open
Traditionally founded in the arts and architecture, design studios provide a distinctively inquiry-based, student-centered environment in which creative problem-solving potential is unfolded through iterative hands-on experimentation. A ke…
View article: Future prospects in the tissue engineering of heart valves: a focus on the role of stem cells
Future prospects in the tissue engineering of heart valves: a focus on the role of stem cells Open
In the field of TEHVs, we see a variety of approaches in cell source, biomaterial, and maturation methods. Choosing appropriate cell populations may be very patient specific; consistency and predictability will be key to long-term success.…
View article: Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction
Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction Open
Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces genera…
View article: Soft, strong, tough, and durable protein-based fiber hydrogels
Soft, strong, tough, and durable protein-based fiber hydrogels Open
Load-bearing soft tissues normally show J-shaped stress–strain behaviors with high compliance at low strains yet high strength at high strains. They have high water content but are still tough and durable. By contrast, naturally derived hy…
View article: Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction
Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction Open
Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces genera…
View article: Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets
Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets Open
3D heterogeneous and anisotropic scaffolds that approximate native heart valve tissues are indispensable for the successful construction of tissue engineered heart valves (TEHVs). In this study, novel tri‐layered and gel‐like nanofibrous s…
View article: OCT4-mediated inflammation induces cell reprogramming at the origin of cardiac valve development and calcification
OCT4-mediated inflammation induces cell reprogramming at the origin of cardiac valve development and calcification Open
Cell reprogramming is at the origin of valve calcification.
View article: Local fluid shear stress operates a molecular switch to drive fetal semilunar valve extension
Local fluid shear stress operates a molecular switch to drive fetal semilunar valve extension Open
Background While much is known about the genetic regulation of early valvular morphogenesis, mechanisms governing fetal valvular growth and remodeling remain unclear. Hemodynamic forces strongly influence morphogenesis, but it is unknown w…
View article: Incorporating nanocrystalline cellulose into a multifunctional hydrogel for heart valve tissue engineering applications
Incorporating nanocrystalline cellulose into a multifunctional hydrogel for heart valve tissue engineering applications Open
Functional tissue engineered heart valves (TEHV) have been an elusive goal for nearly 30 years. Among the persistent challenges are the requirements for engineered valve leaflets that possess nonlinear elastic tissue biomechanical properti…
View article: Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve
Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve Open
During valvulogenesis, cytoskeletal, secretory and transcriptional events drive endocardial cushion growth and remodeling into thin fibrous leaflets. Genetic disorders play an important role in understanding valve malformations but only ac…
View article: Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease
Inflammatory and Biomechanical Drivers of Endothelial-Interstitial Interactions in Calcific Aortic Valve Disease Open
Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy exists outside of prosthetic replacement. The increasing proportion of younger and more active patients mandates alternative therapies. Studies sugge…
View article: Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome
Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome Open
Congenital heart defects (CHDs) are abnormalities in the heart structure present at birth. One important condition is hypoplastic left heart syndrome (HLHS) where severely underdeveloped left ventricle (LV) cannot support systemic circulat…
View article: Age related extracellular matrix and interstitial cell phenotype in pulmonary valves
Age related extracellular matrix and interstitial cell phenotype in pulmonary valves Open
Heart valve disease is a common manifestation of cardiovascular disease and is a significant cause of cardiovascular morbidity and mortality worldwide. The pulmonary valve (PV) is of primary concern because of its involvement in common con…