Stephen Lam
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View article: Risk prediction for lung cancer screening: a systematic review and meta-regression
Risk prediction for lung cancer screening: a systematic review and meta-regression Open
Background Lung cancer (LC) is the leading cause of cancer mortality, often diagnosed at advanced stages. Screening reduces mortality in high-risk individuals, but its efficiency can improve with pre- and post-screening risk stratification…
View article: Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci
Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci Open
Despite lung cancer affecting all races and ethnicities, disparities are observed in incidence and mortality rates among different ethnic groups in the United States. Non-Hispanic African Americans had a high incidence rate of lung cancer …
View article: Incidental findings during lung low‐dose computed tomography cancer screening in Australia and Canada, 2016–21: a prospective observational study
Incidental findings during lung low‐dose computed tomography cancer screening in Australia and Canada, 2016–21: a prospective observational study Open
Objectives To investigate the type and frequency of incidental findings in people at high risk of lung cancer who undergo baseline low‐dose computed tomography (LDCT) lung cancer screening in Australia and Canada. Study design Prospective …
View article: The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study
The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study Open
Introduction The rapid growth in popularity of e-cigarettes over the past decade has prompted concerns about their impact on long-term respiratory health. Small airway injury is suspected to be a direct consequence of e-cigarette use and m…
View article: Machine Learning and Computed Tomography Radiomics to Predict Disease Progression to Upfront Pembrolizumab Monotherapy in Advanced Non-Small-Cell Lung Cancer: A Pilot Study
Machine Learning and Computed Tomography Radiomics to Predict Disease Progression to Upfront Pembrolizumab Monotherapy in Advanced Non-Small-Cell Lung Cancer: A Pilot Study Open
Background/Objectives: Pembrolizumab monotherapy is approved in Canada for first-line treatment of advanced NSCLC with PD-L1 ≥ 50% and no EGFR/ALK aberrations. However, approximately 55% of these patients do not respond to pembrolizumab, u…
View article: Stability of volatile organic compounds in thermal desorption tubes and in solution
Stability of volatile organic compounds in thermal desorption tubes and in solution Open
Exhaled breath volatile organic compounds (VOCs) are often collected and stored in sorbent tubes before thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) analysis. Information about the stability of VOCs during storage is …
View article: Confirmation of Recurrent Lung Cancer Following Resection Using Liquid Biopsy, a Proof-of-Concept Real-World Study
Confirmation of Recurrent Lung Cancer Following Resection Using Liquid Biopsy, a Proof-of-Concept Real-World Study Open
Appropriate management requires timely and accurate confirmation of non-small cell lung cancer (NSCLC) recurrence in patients who have had curative-intent surgical resection. We assessed the association between circulating tumor DNA (ctDNA…
View article: Benchmarking breath analysis using peppermint approach with gas chromatography ion mobility spectrometer coupled to micro thermal desorber
Benchmarking breath analysis using peppermint approach with gas chromatography ion mobility spectrometer coupled to micro thermal desorber Open
The Peppermint Initiative, established within the International Association of Breath Research, introduced the peppermint protocol, a breath analysis benchmarking effort designed to address the lack of inter-comparability of outcomes acros…
View article: Recommendations to Improve Management of Incidental Pulmonary Nodules in Canada: Expert Panel Consensus
Recommendations to Improve Management of Incidental Pulmonary Nodules in Canada: Expert Panel Consensus Open
Introduction: Incidental pulmonary nodules (IPN) are common radiologic findings, yet management of IPNs is inconsistent across Canada. This study aims to improve IPN management based on multidisciplinary expert consensus and provides recom…
View article: Air pollution and lung cancer
Air pollution and lung cancer Open
Outdoor air pollution and particulate matter (PM) in outdoor air is a major cause of lung cancer. The purpose of this article is to review the current knowledge regarding the effects of outdoor air pollution on lung cancer development and …
View article: Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers
Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers Open
Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility…
View article: Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers
Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers Open
Background: Evidence from observational studies of telomere length (TL) has been conflicting regarding its direction of association with cancer risk. We investigated the causal relevance of TL for lung and head and neck cancers using Mende…
View article: Supplementary Table S2 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Supplementary Table S2 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Table S2 shows the signals at known susceptibility loci from ever- and never-smoking lung cancer.
View article: Figure S3 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Figure S3 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Figure S3 displays the Validation of the association effect of rs6757077 at IKZF2 using data from six independent study sites in China.
View article: Supplementary Table S1 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Supplementary Table S1 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Table S1 displays the number of ever- and never-smokers from each of the ten studies.
View article: Figure S1 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Figure S1 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Figure S1 displays the distribution of histology subtypes in each population in ever- and never-smokers.
View article: Supplementary Table S6 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Supplementary Table S6 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Table S6 displays epigenomic evidence for the variants being located within genomic regions associated with regulatory activity.
View article: Supplementary Table S5 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Supplementary Table S5 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Table S5 shows the signals for the variants in stratified analysis by smoking behavior
View article: Figure S4 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Figure S4 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Figure S4 shows the results of eQTL analysis of rs968516 in GTEx.
View article: Figure S2 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Figure S2 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Figure S2 shows the bar chart of lung cancer risk across different smoking strata in EUR, EAS and AFR.
View article: Supplementary Table S1 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Supplementary Table S1 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Table S1 displays the number of ever- and never-smokers from each of the ten studies.
View article: Figure S2 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Figure S2 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Figure S2 shows the bar chart of lung cancer risk across different smoking strata in EUR, EAS and AFR.
View article: Supplementary Table S2 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Supplementary Table S2 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Table S2 shows the signals at known susceptibility loci from ever- and never-smoking lung cancer.
View article: Supplementary Table S7 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Supplementary Table S7 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Supplementary Table S7 shows the signals from interaction with smoking status for the identified variants in lung cancer.
View article: Data from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Data from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies Open
Background:Clinical, molecular, and genetic epidemiology studies displayed remarkable differences between ever- and never-smoking lung cancer.Methods:We conducted a stratified multi-population (European, East Asian, and African descent) as…