Tim Cheetham
YOU?
Author Swipe
View article: Predictors of surgical complications in boys with hypospadias: data from an international registry
Predictors of surgical complications in boys with hypospadias: data from an international registry Open
Background Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence. Methods Data from boys with hypospadias born between 2000 and 2020 were obtained from …
View article: Type 1 diabetes in North East England and North Cumbria: patterns and time trends in 0–14-year-olds from 2012 to 2020
Type 1 diabetes in North East England and North Cumbria: patterns and time trends in 0–14-year-olds from 2012 to 2020 Open
Introduction It is important to understand patterns in the epidemiology of type 1 diabetes because they may provide insight into its etiology. We examined the incidence of type 1 diabetes in children aged 0–14 years, and patient demographi…
View article: Emergency and perioperative management of adrenal insufficiency in children and young people: British Society for Paediatric Endocrinology and Diabetes consensus guidance
Emergency and perioperative management of adrenal insufficiency in children and young people: British Society for Paediatric Endocrinology and Diabetes consensus guidance Open
Adrenal insufficiency (AI) is characterised by lack of cortisol production from the adrenal glands. This can be a primary adrenal disorder or secondary to adrenocorticotropic hormone deficiency or suppression from exogenous glucocorticoids…
View article: Muscle Function, Body Composition, Insulin Sensitivity and Physical Activity in Adolescents Born Preterm: Impact of Gestation and Vitamin D Status
Muscle Function, Body Composition, Insulin Sensitivity and Physical Activity in Adolescents Born Preterm: Impact of Gestation and Vitamin D Status Open
Whilst several studies have explored adolescent metabolic and cognitive function after preterm birth, few have explored muscle function and physical activity. We set out to examine the relationship between gestational age and muscle metabo…
View article: Graves’ disease: moving forwards
Graves’ disease: moving forwards Open
Graves’ disease is a rare disorder that continues to present clinicians and families with a series of challenges. There are no new established treatments for children or adolescents, but the outcomes of recent clinical trials and meta-anal…
View article: Adjuvant Rituximab - exploratory trial in young people with Graves’ disease
Adjuvant Rituximab - exploratory trial in young people with Graves’ disease Open
Context Remission rates in young people with Graves hyperthyroidism are less than 25% after 2 years of thionamide antithyroid drug (ATD). Objective We explored whether rituximab (RTX), a B-lymphocyte–depleting agent, would increase remissi…
View article: Processing of Positive Newborn Screening Results for Congenital Hypothyroidism: A Qualitative Exploration of Current Practice in England
Processing of Positive Newborn Screening Results for Congenital Hypothyroidism: A Qualitative Exploration of Current Practice in England Open
The objective of this research was to explore current communication practices for positive newborn bloodspot screening results for congenital hypothyroidism from the newborn bloodspot screening laboratory to clinicians and then families, i…
View article: Obesity-Associated <i>GNAS</i> Mutations and the Melanocortin Pathway
Obesity-Associated <i>GNAS</i> Mutations and the Melanocortin Pathway Open
Because pathogenic mutations may manifest with obesity alone, screening of children with severe obesity for GNAS deficiency may allow early diagnosis, improving clinical outcomes, and melanocortin agonists may aid in weight loss. GNAS muta…
View article: Quality of life in craniopharyngioma: sorting out cause from association
Quality of life in craniopharyngioma: sorting out cause from association Open
This commentary is on the original article by Niel et al. on pages 984–990 of this issue.
View article: Genetic Analysis of Pediatric Primary Adrenal Insufficiency of Unknown Etiology: 25 Years’ Experience in the UK
Genetic Analysis of Pediatric Primary Adrenal Insufficiency of Unknown Etiology: 25 Years’ Experience in the UK Open
Context Although primary adrenal insufficiency (PAI) in children and young people is often due to congenital adrenal hyperplasia (CAH) or autoimmunity, other genetic causes occur. The relative prevalence of these conditions is poorly under…
View article: Quality of Life in Children and Young People With Congenital Adrenal Hyperplasia in the United Kingdom - Nationwide Multicentre Assessment
Quality of Life in Children and Young People With Congenital Adrenal Hyperplasia in the United Kingdom - Nationwide Multicentre Assessment Open
Introduction: Impaired Quality of Life (QoL) in Congenital Adrenal Hyperplasia (CAH) has been demonstrated in adults, but research in children has yielded variable results. We investigated the impact of CAH on QoL of children and adolescen…
View article: Congenital Hypothyroidism: Space–Time Clustering of Thyroid Dysgenesis Indicates a Role for Environmental Factors in Disease Etiology
Congenital Hypothyroidism: Space–Time Clustering of Thyroid Dysgenesis Indicates a Role for Environmental Factors in Disease Etiology Open
Background: The etiology of most cases of congenital hypothyroidism (CHT) due to thyroid dysgenesis (DG) is unknown. If transient environmental factors can impact on thyroid gland development, then clustering of cases in time and/or space …
View article: A survey of the young person’s experience of Graves’ disease and its management
A survey of the young person’s experience of Graves’ disease and its management Open
Objective A suboptimal quality of life (QoL) has been reported in patients with Graves’ disease treated in adult life, but long‐term QoL in those treated in childhood and adolescence is unclear. We wanted to understand how Graves’ disease …
View article: Measurement of salivary testosterone in adolescents and young men with Duchenne muscular dystrophy
Measurement of salivary testosterone in adolescents and young men with Duchenne muscular dystrophy Open
Background Many young adults with Duchenne Muscular Dystrophy (DMD) receive long-term glucocorticoids (GC). GC can cause hypogonadotrophic hypogonadism and adolescents may therefore be candidates for pubertal induction. It is unclear wheth…
View article: New Therapeutic Horizons for Graves’ Hyperthyroidism
New Therapeutic Horizons for Graves’ Hyperthyroidism Open
Graves’ hyperthyroidism is characterized by the presence of autoantibodies that stimulate the thyroid-stimulating hormone receptor (TSHR), resulting in uncontrolled secretion of excessive thyroid hormone. Conventional treatments, including…
View article: Refinement of the critical genomic region for congenital hyperinsulinism in the Chromosome 9p deletion syndrome
Refinement of the critical genomic region for congenital hyperinsulinism in the Chromosome 9p deletion syndrome Open
Background: Large contiguous gene deletions at the distal end of the short arm of chromosome 9 result in the complex multi-organ condition chromosome 9p deletion syndrome. A range of clinical features can result from these deletions with t…
View article: Measurement of salivary testosterone in adolescents and young men with Duchenne muscular dystrophy
Measurement of salivary testosterone in adolescents and young men with Duchenne muscular dystrophy Open
Background Many young adults with Duchenne Muscular Dystrophy (DMD) receive long-term glucocorticoids (GC). GC can cause hypogonadotrophic hypogonadism and adolescents may therefore be candidates for pubertal induction. It is unclear wheth…
View article: Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes
Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes Open
OBJECTIVE Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim was to assess…
View article: Using referral rates for genetic testing to determine the incidence of a rare disease: The minimal incidence of congenital hyperinsulinism in the UK is 1 in 28,389
Using referral rates for genetic testing to determine the incidence of a rare disease: The minimal incidence of congenital hyperinsulinism in the UK is 1 in 28,389 Open
Congenital hyperinsulinism (CHI) is a significant cause of hypoglycaemia in neonates and infants with the potential for permanent neurologic injury. Accurate calculations of the incidence of rare diseases such as CHI are important as they …
View article: Significant Benefits of <i>AIP</i> Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors
Significant Benefits of <i>AIP</i> Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors Open
Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective T…
View article: Randomised Trial of Block and Replace versus dose titration antithyroid drug treatment in children and adolescents with thyrotoxicosis.
Randomised Trial of Block and Replace versus dose titration antithyroid drug treatment in children and adolescents with thyrotoxicosis. Open
This dataset contains the study regimens for the randomised controlled trial. Context First line treatment of thyrotoxicosis in young people is thionamide antithyroid drug (ATD) in a blocking dose with levothyroxine replacement (block and…
View article: The Lived Experience of Klinefelter Syndrome: A Narrative Review of the Literature
The Lived Experience of Klinefelter Syndrome: A Narrative Review of the Literature Open
Opinion Article
View article: Refinement of the critical genomic region for hypoglycaemia in the Chromosome 9p deletion syndrome
Refinement of the critical genomic region for hypoglycaemia in the Chromosome 9p deletion syndrome Open
Background: Large contiguous gene deletions at the distal end of the short arm of chromosome 9 result in the complex multi-organ condition chromosome 9p deletion syndrome. A range of clinical features can result from these deletions with t…
View article: Newborn screening for primary congenital hypothyroidism: estimating test performance at different TSH thresholds
Newborn screening for primary congenital hypothyroidism: estimating test performance at different TSH thresholds Open
This nationwide prospective surveillance study aimed to estimate the performance of the current UK recommended TSH threshold (10 mU/L on day 5 after birth) for newborn blood spot screening compared to lower thresholds: 8 mU/L and 6 mU/L. O…