Eoin OʼBrien
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View article: Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review
Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review Open
Breast-conserving surgery with whole breast irradiation (WBI) is the standard of care for early-stage breast cancer which provides similar local control and survival outcomes to mastectomy alone. Advances in radiation therapy (RT), such as…
View article: Ambulatory blood pressure monitoring, European guideline targets, and cardiovascular outcomes: an individual patient data meta-analysis
Ambulatory blood pressure monitoring, European guideline targets, and cardiovascular outcomes: an individual patient data meta-analysis Open
Background and Aims Hypertension is the predominant modifiable cardiovascular risk factor. This cohort study assessed the association of risk with the percentage of time that the ambulatory blood pressure (ABP) is within the target range (…
View article: 23 What’s the Big Idea? Using Blended Learning Approaches to Support the Development of Entrepreneurial Competencies in Tourism and Hospitality Education
23 What’s the Big Idea? Using Blended Learning Approaches to Support the Development of Entrepreneurial Competencies in Tourism and Hospitality Education Open
View article: Knowing the dancer from the dance – Exploring the influence of Teaching Portfolios in Entrepreneurial Education
Knowing the dancer from the dance – Exploring the influence of Teaching Portfolios in Entrepreneurial Education Open
Entrepreneurship has become a global phenomenon and there has been significant growth in entrepreneurial education in Higher Education Institutions to support this trend. Consequently, research in entrepreneurial education has developed ra…
View article: Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial
Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial Open
The Stroke Association and British Heart Foundation.
View article: OC 55.2 Dimethyl Fumarate and 4-Octyl Itaconate are Anticoagulants that Suppress Tissue Factor in Macrophages Via Inhibition of Type I Interferon
OC 55.2 Dimethyl Fumarate and 4-Octyl Itaconate are Anticoagulants that Suppress Tissue Factor in Macrophages Via Inhibition of Type I Interferon Open
demonstrate the importance of systemic NET release under metabolic challenge, and how this can contribute to cardiac deterioration at a young age due to obesity-induced alteration of the innate immune system.
View article: Author Response: Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia
Author Response: Extensive re-modelling of the cell wall during the development of Staphylococcus aureus bacteraemia Open
The bloodstream represents a hostile environment that bacteria must overcome to cause bacteraemia. To understand how the major human pathogen Staphylococcus aureus manages this we have utilised a functional genomics approach to identify a …
View article: Home blood pressure monitoring: methodology, clinical relevance and practical application: a 2021 position paper by the Working Group on Blood Pressure Monitoring and Cardiovascular Variability of the European Society of Hypertension
Home blood pressure monitoring: methodology, clinical relevance and practical application: a 2021 position paper by the Working Group on Blood Pressure Monitoring and Cardiovascular Variability of the European Society of Hypertension Open
The present paper provides an update of previous recommendations on Home Blood Pressure Monitoring from the European Society of Hypertension (ESH) Working Group on Blood Pressure Monitoring and Cardiovascular Variability sequentially publi…
View article: May Measurement Month 2019: an analysis of blood pressure screening results from the United Kingdom and Republic of Ireland
May Measurement Month 2019: an analysis of blood pressure screening results from the United Kingdom and Republic of Ireland Open
In the UK, heart and circulatory diseases account for 29% of all deaths (14% through coronary heart disease and 8% through stroke). In 2015, the prevalence of hypertension was 20% in the UK and 23% in the Republic of Ireland. In 2019, 14% …
View article: 2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement
2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement Open
Collaborators: Lucas Aparicio (Argentina), Kei Asayama (Japan), Roland Asmar (France), Grzegorz Bilo (Italy), Jean-Marc Boivin (France), Alejandro de la Sierra (Spain), Eamon Dolan (Ireland), Jan Filipovsky (Czech Republic), Geoffrey Head …
View article: Relative and Absolute Risk to Guide the Management of Pulse Pressure, an Age-Related Cardiovascular Risk Factor
Relative and Absolute Risk to Guide the Management of Pulse Pressure, an Age-Related Cardiovascular Risk Factor Open
Background Pulse pressure (PP) reflects the age-related stiffening of the central arteries, but no study addressed the management of the PP-related risk over the human lifespan. Methods In 4,663 young (18–49 years) and 7,185 older adults (…
View article: Ambulatory Blood Pressure Monitoring to Diagnose and Manage Hypertension
Ambulatory Blood Pressure Monitoring to Diagnose and Manage Hypertension Open
This review portrays how ambulatory blood pressure (BP) monitoring was established and recommended as the method of choice for the assessment of BP and for the rational use of antihypertensive drugs. To establish much-needed diagnostic amb…
View article: Association of Fatal and Nonfatal Cardiovascular Outcomes With 24-Hour Mean Arterial Pressure
Association of Fatal and Nonfatal Cardiovascular Outcomes With 24-Hour Mean Arterial Pressure Open
Major adverse cardiovascular events are closely associated with 24-hour blood pressure (BP). We determined outcome-driven thresholds for 24-hour mean arterial pressure (MAP), a BP index estimated by oscillometric devices. We assessed the a…
View article: May Measurement Month 2018: an analysis of blood pressure screening results from the UK and the Republic of Ireland
May Measurement Month 2018: an analysis of blood pressure screening results from the UK and the Republic of Ireland Open
Raised blood pressure (BP) was the biggest contributor to the global burden of disease in 2017, with lack of awareness and adequate control of BP identified as the main drivers of this disease burden. In 2017, an opportunistic BP screening…
View article: The Cost-Effectiveness of Universal Varicella Vaccination in Italy: A Model-Based Assessment of Vaccination Strategies
The Cost-Effectiveness of Universal Varicella Vaccination in Italy: A Model-Based Assessment of Vaccination Strategies Open
C Azzari,1 V Baldo,2 S Giuffrida,3 R Gani,4 E O’Brien,5 C Alimenti,6 VJ Daniels,7 LJ Wolfson7 1Department of Health Sciences, University of Florence and Meyer Children’s University Hospital, Florence 50139, Italy; 2Hygi…
View article: Lancet commission on hypertension group position statement on the global improvement of accuracy standards for devices that measure blood pressure
Lancet commission on hypertension group position statement on the global improvement of accuracy standards for devices that measure blood pressure Open
The Lancet Commission on Hypertension identified that a key action to address the worldwide burden of high blood pressure (BP) was to improve the quality of BP measurements by using BP devices that have been validated for accuracy. Current…
View article: Declaración de posición del Grupo de la Comisión Lancet de Hipertensión con respecto a la mejora mundial de las normas de exactitud para los dispositivos de medición de la presión arterial
Declaración de posición del Grupo de la Comisión Lancet de Hipertensión con respecto a la mejora mundial de las normas de exactitud para los dispositivos de medición de la presión arterial Open
La Comisión Lancet de Hipertensión determinó que una medida clave para responder a la carga mundial que representa la hipertensión arterial era mejorar la calidad de las mediciones de la presión arterial, mediante la utilización de disposi…
View article: STRIDE BP international initiative for accurate blood pressure measurement: Systematic review of published validation studies of blood pressure measuring devices
STRIDE BP international initiative for accurate blood pressure measurement: Systematic review of published validation studies of blood pressure measuring devices Open
Blood pressure (BP) is a vital sign, and its measurement is essential for diagnosing and treating hypertension. The accuracy of BP monitors is therefore essential, but unfortunately very few devices available on the market have been valida…
View article: Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure
Opposing Age-Related Trends in Absolute and Relative Risk of Adverse Health Outcomes Associated With Out-of-Office Blood Pressure Open
Participant-level meta-analyses assessed the age-specific relevance of office blood pressure to cardiovascular complications, but this information is lacking for out-of-office blood pressure. At baseline, daytime ambulatory (n=12 624) or h…
View article: The impact of systolic and diastolic blood pressure variability on mortality is age dependent: Data from the Dublin Outcome Study
The impact of systolic and diastolic blood pressure variability on mortality is age dependent: Data from the Dublin Outcome Study Open
Background Twenty-four-hour blood pressure variability (BPV) is independently related to cardiovascular outcomes, but limited and conflicting evidence is available on the relative prognostic importance of systolic and diastolic BPV. The ai…
View article: Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes
Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes Open
In this population-based cohort study, higher 24-hour and nighttime blood pressure measurements were significantly associated with greater risks of death and a composite CV outcome, even after adjusting for other office-based or ambulatory…
View article: Measuring adherence to therapy in apparent treatment-resistant hypertension: a feasibility study in Irish primary care
Measuring adherence to therapy in apparent treatment-resistant hypertension: a feasibility study in Irish primary care Open
Background Apparent treatment-resistant hypertension (aTRH) is defined as uncontrolled blood pressure (BP) in patients taking three or more antihypertensive medications. Some patients will have true treatment-resistant hypertension, some u…
View article: Recommendations and Practical Guidance for performing and reporting validation studies according to the Universal Standard for the validation of blood pressure measuring devices by the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO)
Recommendations and Practical Guidance for performing and reporting validation studies according to the Universal Standard for the validation of blood pressure measuring devices by the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Open
: In the past 30 years, several organizations have developed protocols for clinical validation of blood pressure measuring devices. An international initiative was recently launched by the US Association for the Advancement of Medical Inst…
View article: Validation protocols for blood pressure measuring devices in the 21st century
Validation protocols for blood pressure measuring devices in the 21st century Open
Blood pressure ( BP ) is a vital sign and the essential measurement for the diagnosis of hypertension. Therefore, its accurate measurement is a key element for the evaluation of many medical conditions and for the reliable diagnosis and ef…
View article: Accurate blood pressure measuring devices: Influencing users in the 21st century
Accurate blood pressure measuring devices: Influencing users in the 21st century Open
Hypertension is now recognized as a major global cause of morbidity and death. All decisions relating to the epidemiology, diagnosis, and management of hypertension are dependent on being able to measure blood pressure accurately. Scientis…
View article: Ambulatory blood pressure monitoring in the 21st century
Ambulatory blood pressure monitoring in the 21st century Open
In clinical practice, ambulatory blood pressure monitoring ( ABPM ) tends to be used solely for diagnosing hypertension, especially to identify white‐coat and masked hypertension. However, ABPM can provide additional information to guide t…
View article: Achieving reliable blood pressure measurements in clinical practice: It's time to meet the challenge
Achieving reliable blood pressure measurements in clinical practice: It's time to meet the challenge Open
A summary of statements for blood pressure (BP) measurement in the evaluation of hypertension in the 21st century by 25 international experts is provided. The status of office, home and ambulatory BP measurement techniques are discussed. O…
View article: The quest for accuracy of blood pressure measuring devices
The quest for accuracy of blood pressure measuring devices Open
The accuracy of blood pressure ( BP ) measuring devices is fundamental to good practice and scientific research. International guidelines on BP measurement are provided for clinicians who diagnose and treat patients with hypertension, clin…
View article: Patterns of ambulatory blood pressure: clinical relevance and application
Patterns of ambulatory blood pressure: clinical relevance and application Open
Ambulatory blood pressure measurement ( ABPM ) is now recommended in all patients suspected of having hypertension. However, in practice, the mean daytime pressures are often used to make diagnostic and therapeutic decisions, and the infor…
View article: Evidence-based proposal for the number of ambulatory readings required for assessing blood pressure level in research settings: an analysis of the IDACO database
Evidence-based proposal for the number of ambulatory readings required for assessing blood pressure level in research settings: an analysis of the IDACO database Open
24-h ambulatory recordings with ≥8/≥4 awake/asleep readings yielded ABP levels similar to recordings including the guideline-recommended ≥20/≥7 readings. These criteria save valuable data in a research setting, but are not applicable to cl…