Thomas Eade
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View article: Vaccine-induced immunity is maintained in glioma patients relative to other solid tumours
Vaccine-induced immunity is maintained in glioma patients relative to other solid tumours Open
This study demonstrates that glioma patients can mount meaningful immune responses to DNA and mRNA vaccines, suggesting that glioma-based vaccine therapies are feasible and warrant further exploration.
View article: COVID-19 vaccinations in COVID-19 naïve population to predict utility of tumour-based vaccinations in glioma patients
COVID-19 vaccinations in COVID-19 naïve population to predict utility of tumour-based vaccinations in glioma patients Open
Background Gliomas are the most common primary brain malignancy in adults, with treatment advances limited by challenges like the blood-brain barrier, tumour heterogeneity, and an immunosuppressive microenvironment. Tumour vaccines, such a…
View article: Surveillance After Treatment of Adenoid Cystic Carcinoma of the Head and Neck: Review of Institutional Outcomes and Proposed Surveillance Imaging Protocol
Surveillance After Treatment of Adenoid Cystic Carcinoma of the Head and Neck: Review of Institutional Outcomes and Proposed Surveillance Imaging Protocol Open
Introduction Long term survival for adenoid cystic carcinoma (ACC) arising from the head and neck declines for many decades after initial treatment due to late disease relapse. Follow up and surveillance imaging practices vary due to limit…
View article: Oral Microbiome as a Biomarker and Therapeutic Target in Head and Neck Cancer: Current Insights and Future Directions
Oral Microbiome as a Biomarker and Therapeutic Target in Head and Neck Cancer: Current Insights and Future Directions Open
Background/Objectives: The oral microbiome has been implicated in the pathogenesis of head and neck squamous cell carcinoma (HNSCC). This review examines the association between specific oral bacterial taxa and HNSCC. Methods: A systematic…
View article: Simulation‐Free Palliative Radiation Therapy: Implementing the Value‐Based and Easier‐Access Model of Care in a Rural Setting
Simulation‐Free Palliative Radiation Therapy: Implementing the Value‐Based and Easier‐Access Model of Care in a Rural Setting Open
Palliative radiation therapy (RT) is a vital treatment modality for managing symptoms from metastatic disease, but access barriers and workflow inefficiencies can delay or preclude care delivery. Simulation‐free RT (SFRT) offers an effecti…
View article: Patient-specific prostate segmentation in kilovoltage images for radiation therapy intrafraction monitoring via deep learning
Patient-specific prostate segmentation in kilovoltage images for radiation therapy intrafraction monitoring via deep learning Open
Background During radiation therapy, the natural movement of organs can lead to underdosing the cancer and overdosing the healthy tissue, compromising treatment efficacy. Real-time image-guided adaptive radiation therapy can track the tumo…
View article: Adjuvant External Beam Radiotherapy Reduces Local Recurrence in Poorly Differentiated Thyroid Cancer
Adjuvant External Beam Radiotherapy Reduces Local Recurrence in Poorly Differentiated Thyroid Cancer Open
Background Poorly differentiated thyroid carcinoma (PDTC) accounts for 5% of all thyroid cancers and is responsible for a large proportion of thyroid cancer-related deaths. The optimal treatment approach is not clear. This study aimed to e…
View article: “I've got plenty of energy when I’m doing something I want to do”: applying self-determination theory to exercise motivation in people with prostate cancer
“I've got plenty of energy when I’m doing something I want to do”: applying self-determination theory to exercise motivation in people with prostate cancer Open
View article: Avoiding prostate bed radiation for the PSMA-PET detected nodal recurrence patient post prostatectomy
Avoiding prostate bed radiation for the PSMA-PET detected nodal recurrence patient post prostatectomy Open
View article: The TROG 15.01 stereotactic prostate adaptive radiotherapy utilizing kilovoltage intrafraction monitoring (SPARK) clinical trial database
The TROG 15.01 stereotactic prostate adaptive radiotherapy utilizing kilovoltage intrafraction monitoring (SPARK) clinical trial database Open
Purpose The US National Institutes of Health state that Sharing of clinical trial data has great potential to accelerate scientific progress and ultimately improve public health by generating better evidence on the safety and effectiveness…
View article: Real-World Implementation of Simulation-Free Radiation Therapy (SFRT-1000): A Propensity Score-Matched Analysis of 1000 Consecutive Palliative Courses Delivered in Routine Care
Real-World Implementation of Simulation-Free Radiation Therapy (SFRT-1000): A Propensity Score-Matched Analysis of 1000 Consecutive Palliative Courses Delivered in Routine Care Open
In this single-institution, retrospective cohort study, all patients receiving palliative radiation therapy at an Australian tertiary cancer center were eligible for consideration of SFRT unless mask immobilization, a stereotactic techniqu…
View article: Anaplastic thyroid cancer: A review of recent evidence and summary of an Australian institutional protocol
Anaplastic thyroid cancer: A review of recent evidence and summary of an Australian institutional protocol Open
Anaplastic thyroid cancer (ATC), a rare and highly aggressive malignancy, is characterized by an exceptionally poor prognosis, where the majority of patients present with extensive local invasion and/or distant metastases. 20–30% of ATCs h…
View article: An elusive prostate tumour: Metastatic microcystic cribriform carcinoma presenting with imaging-histologic discordance
An elusive prostate tumour: Metastatic microcystic cribriform carcinoma presenting with imaging-histologic discordance Open
View article: Durvalumab and radiotherapy without androgen deprivation for oligometastatic prostate cancer
Durvalumab and radiotherapy without androgen deprivation for oligometastatic prostate cancer Open
View article: Radiological evaluation of an iodised hydrogel for prostate radiotherapy applications
Radiological evaluation of an iodised hydrogel for prostate radiotherapy applications Open
SpaceOAR Vue™ was found to be radio-opaque on kV images, but dosimetrically behaved similarly to water in MV treatment beams, making it suitable for clinical use.
View article: Evaluation of the clinical feasibility of cone-beam computed tomography guided online adaption for simulation-free palliative radiotherapy
Evaluation of the clinical feasibility of cone-beam computed tomography guided online adaption for simulation-free palliative radiotherapy Open
The CBCT-guided oART system utilising a simulation-free planning approach was found to be sufficiently accurate for clinical implementation, this may further streamline and improve care for palliative patients.
View article: Long-term outcomes of SBRT for PSMA PET detected oligometastatic prostate cancer
Long-term outcomes of SBRT for PSMA PET detected oligometastatic prostate cancer Open
Background Oligometastatic disease in prostate cancer (PCa) is a challenging clinical scenario encountered more frequently with the widespread adoption of PSMA-PET. SBRT aims to defer androgen deprivation and may deliver sustained biochemi…
View article: The Prostate Problem You Can’t Put Your Finger on the Normal Way: A Case of Perineal Prostate Cancer Post Transperineal Prostate Biopsy
The Prostate Problem You Can’t Put Your Finger on the Normal Way: A Case of Perineal Prostate Cancer Post Transperineal Prostate Biopsy Open
None.
View article: Long-Term Outcomes of TROG 13.01 SAFRON II Randomized Trial of Single- Versus Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases
Long-Term Outcomes of TROG 13.01 SAFRON II Randomized Trial of Single- Versus Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases Open
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. …
View article: Genomic Classifiers in Personalized Prostate Cancer Radiation Therapy Approaches: A Systematic Review and Future Perspectives Based on International Consensus
Genomic Classifiers in Personalized Prostate Cancer Radiation Therapy Approaches: A Systematic Review and Future Perspectives Based on International Consensus Open
Current risk-stratification systems for prostate cancer (PCa) do not sufficiently reflect the disease heterogeneity. Genomic classifiers (GC) enable improved risk stratification after surgery, but less data exist for patients treated with …
View article: Event‐free survival after radical prostatectomy according to prostate‐specific membrane antigen‐positron emission tomography and <scp>European Association of Urology</scp> biochemical recurrence risk groups
Event‐free survival after radical prostatectomy according to prostate‐specific membrane antigen‐positron emission tomography and <span>European Association of Urology</span> biochemical recurrence risk groups Open
Objective To assess European Association of Urology (EAU) risk groups for biochemical recurrence (BCR) of prostate cancer relative to prostate‐specific membrane antigen‐positron emission tomography (PSMA‐PET) status and oncological outcome…
View article: Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data
Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data Open
KBP created high quality PPRT plans using the data from a multicentre clinical trial in a single optimisation. It is a powerful tool for utilisation in clinical trials for patient specific QA, to reduce dose to surrounding OARs and variati…
View article: Refractory Riedel’s thyroiditis managed with low dose radiotherapy
Refractory Riedel’s thyroiditis managed with low dose radiotherapy Open
View article: The Gut Microbiome and Cancer Immunotherapy: Can We Use the Gut Microbiome as a Predictive Biomarker for Clinical Response in Cancer Immunotherapy?
The Gut Microbiome and Cancer Immunotherapy: Can We Use the Gut Microbiome as a Predictive Biomarker for Clinical Response in Cancer Immunotherapy? Open
Background: Emerging evidence suggests that gut microbiota influences the clinical response to immunotherapy. This review of clinical studies examines the relationship between gut microbiota and immunotherapy outcomes. Method: A literature…
View article: Emerging Evidence of the Gut Microbiome in Chemotherapy: A Clinical Review
Emerging Evidence of the Gut Microbiome in Chemotherapy: A Clinical Review Open
Increasing evidence suggests that the gut microbiome is associated with both cancer chemotherapy (CTX) outcomes and adverse events (AEs). This review examines the relationship between the gut microbiome and CTX as well as the impact of CTX…
View article: Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II)
Single-Fraction vs Multifraction Stereotactic Ablative Body Radiotherapy for Pulmonary Oligometastases (SAFRON II) Open
ClinicalTrials.gov Identifier: NCT01965223.
View article: Comprehensive nodal breast VMAT: solving the low‐dose wash dilemma using an iterative knowledge‐based radiotherapy planning solution
Comprehensive nodal breast VMAT: solving the low‐dose wash dilemma using an iterative knowledge‐based radiotherapy planning solution Open
Introduction Aimed to develop a simple and robust volumetric modulated arc radiotherapy (VMAT) solution for comprehensive lymph node (CLN) breast cancer without increase in low‐dose wash. Methods Forty CLN‐breast patient data sets were uti…
View article: Correction to: Multimodality Treatment Improves Locoregional Control, Progression-Free and Overall Survival in Patients with Anaplastic Thyroid Cancer: A Retrospective Cohort Study Comparing Oncological Outcomes and Morbidity between Multimodality Treatment and Limited Treatment
Correction to: Multimodality Treatment Improves Locoregional Control, Progression-Free and Overall Survival in Patients with Anaplastic Thyroid Cancer: A Retrospective Cohort Study Comparing Oncological Outcomes and Morbidity between Multimodality Treatment and Limited Treatment Open
View article: Multimodality Treatment Improves Locoregional Control, Progression-Free and Overall Survival in Patients with Anaplastic Thyroid Cancer: A Retrospective Cohort Study Comparing Oncological Outcomes and Morbidity between Multimodality Treatment and Limited Treatment
Multimodality Treatment Improves Locoregional Control, Progression-Free and Overall Survival in Patients with Anaplastic Thyroid Cancer: A Retrospective Cohort Study Comparing Oncological Outcomes and Morbidity between Multimodality Treatment and Limited Treatment Open
View article: The Gut Microbiome and Gastrointestinal Toxicities in Pelvic Radiation Therapy: A Clinical Review
The Gut Microbiome and Gastrointestinal Toxicities in Pelvic Radiation Therapy: A Clinical Review Open
Background: Gastrointestinal (GI) toxicities are common adverse effects of pelvic radiotherapy (RT). Several recent studies revealed that toxicity of RT is associated with dysbiosis of the gut microbiome. Method: A literature search was co…