Richard T. Ellison
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View article: Structural and epistatic regulatory variants cause hallmark white spotting in cattle
Structural and epistatic regulatory variants cause hallmark white spotting in cattle Open
Despite being one of the most iconic and immediately recognizable traits in domestic cattle, the variants underpinning the white-spotted coat pattern of Holstein-Friesian and related breeds remain uncharacterized. Here, we report two varia…
View article: Machine Learning–Enhanced Surveillance for Surgical Site Infections in Patients Undergoing Colon Surgery: Model Development and Evaluation Study
Machine Learning–Enhanced Surveillance for Surgical Site Infections in Patients Undergoing Colon Surgery: Model Development and Evaluation Study Open
Background Surgical site infections (SSIs) are one of the most common health care–associated infections, accounting for nearly 20% of all health care–associated infections in hospitalized patients. SSIs are associated with longer hospital …
View article: Retrospective Analysis of the Clinical Significance of Positive Blood Cultures in the Emergency Department: A Single-Center Study
Retrospective Analysis of the Clinical Significance of Positive Blood Cultures in the Emergency Department: A Single-Center Study Open
Background There have been major advances in blood culture technology in the last decade, with both faster and more sensitive pathogen detection as well as more precise species identification. We have reassessed the results of positive blo…
View article: Emphysematous Pyelonephritis and Concurrent Emphysematous Osteomyelitis
Emphysematous Pyelonephritis and Concurrent Emphysematous Osteomyelitis Open
We present a rare case of emphysematous pyelonephritis complicated by secondary emphysematous osteomyelitis, likely resulting from the hematogenous spread of Escherichia coli in a patient with multiple comorbid conditions. Early identifica…
View article: Machine Learning–Enhanced Surveillance for Surgical Site Infections in Patients Undergoing Colon Surgery: Model Development and Evaluation Study (Preprint)
Machine Learning–Enhanced Surveillance for Surgical Site Infections in Patients Undergoing Colon Surgery: Model Development and Evaluation Study (Preprint) Open
BACKGROUND Surgical site infections (SSIs) are one of the most common health care–associated infections, accounting for nearly 20% of all health care–associated infections in hospitalized patients. SSIs are associated with longer hospital…
View article: Prospective Trial of a Passive Diversion Device to Reduce Blood Culture Contamination
Prospective Trial of a Passive Diversion Device to Reduce Blood Culture Contamination Open
Background Blood culture contaminants can lead to inappropriate antibiotic use, prolonged length of stay, and additional hospital costs. Several devices have been developed to reduce the risk of blood culture contamination by diverting a p…
View article: 228. Increased Incidence of Invasive <i>Haemophilus influenzae</i> Infections in Adults in Central Massachusetts
228. Increased Incidence of Invasive <i>Haemophilus influenzae</i> Infections in Adults in Central Massachusetts Open
Background Since the advent of the Haemophilus influenzae B vaccine, the incidence of infections due to this pathogen has substantially decreased, although occasional cases of severe infections due to other serotypes are observed. Routine …
View article: Use of expert consensus to develop a shared list of procedures with potential for aerosol generation during the coronavirus disease 2019 (COVID-19) pandemic
Use of expert consensus to develop a shared list of procedures with potential for aerosol generation during the coronavirus disease 2019 (COVID-19) pandemic Open
The coronavirus disease 2019 (COVID-19) pandemic highlighted the lack of agreement regarding the definition of aerosol-generating procedures and potential risk to healthcare personnel. We convened a group of Massachusetts healthcare epidem…
View article: 423. Molecular Epidemiology of ESBL E. coli Over a 2 Year Period in Worcester Massachusetts USA
423. Molecular Epidemiology of ESBL E. coli Over a 2 Year Period in Worcester Massachusetts USA Open
Background Extended-spectrum beta-lactamase (ESBL) producing Escherichia coli are an increasing health burden contributing to a pandemic of resistant bacteria. Methods To better understand the population genomics of ESBL E. coli, 129 pheno…
View article: COVID-19 Variant Surveillance and Social Determinants in Central Massachusetts: Development Study
COVID-19 Variant Surveillance and Social Determinants in Central Massachusetts: Development Study Open
Background Public health scientists have used spatial tools such as web-based Geographical Information System (GIS) applications to monitor and forecast the progression of the COVID-19 pandemic and track the impact of their interventions. …
View article: Epidemiological and clinical features of Panton-Valentine Leukocidin positive Staphylococcus aureus bacteremia: A case-control study
Epidemiological and clinical features of Panton-Valentine Leukocidin positive Staphylococcus aureus bacteremia: A case-control study Open
Background Panton-Valentine Leukocidin (PVL) toxin in Staphylococcus aureus has been associated with both severe pneumonia and skin and soft tissue infections. However, there are only limited data on how this virulence factor may influence…
View article: COVID-19 Variant Surveillance and Social Determinants in Central Massachusetts: Development Study (Preprint)
COVID-19 Variant Surveillance and Social Determinants in Central Massachusetts: Development Study (Preprint) Open
BACKGROUND Public health scientists have used spatial tools such as web-based Geographical Information System (GIS) applications to monitor and forecast the progression of the COVID-19 pandemic and track the impact of their interventions.…
View article: 114. Prospective Trial of Passive Diversion Device to Reduce Blood Culture Contamination
114. Prospective Trial of Passive Diversion Device to Reduce Blood Culture Contamination Open
Background Blood culture contaminants can lead to inappropriate antibiotic use, prolonged length of stay, and additional hospital costs. Several devices have been developed to reduce the risk of blood culture contamination by diverting a p…
View article: Expanded access use of rezafungin for salvage therapy of invasive <i>Candida glabrata</i> infection: A case report
Expanded access use of rezafungin for salvage therapy of invasive <i>Candida glabrata</i> infection: A case report Open
Rezafungin is a semi-synthetic, long acting echinocandin with broad spectrum activity against many Candida species (spp)., and Aspergillus spp., including subset of drug-resistant strains. It is currently in phase III trials and was found …
View article: Accuracy of Infection Control Surveillance in Identifying Genomically Confirmed Cross Transmission Clusters
Accuracy of Infection Control Surveillance in Identifying Genomically Confirmed Cross Transmission Clusters Open
Background: Infection prevention surveillance for cross transmission is often performed by manual review of microbiologic culture results to identify geotemporally related clusters. However, the sensitivity and specificity of this approach…
View article: Effect of a Multidisciplinary Team Approach to Eradicate Central Line Associated Blood-Stream Infections (CLABSI)
Effect of a Multidisciplinary Team Approach to Eradicate Central Line Associated Blood-Stream Infections (CLABSI) Open
Introduction: CLABSI remains a significant problem in the intensive care unit. Hypothesis: A multimodal approach for the insertion and care of CVC will prevent CLABSI. Methods: A Critical Care Operations Committee was formed to transform c…
View article: Addressing decontaminated respirators: Some methods appear to damage mask integrity and protective function
Addressing decontaminated respirators: Some methods appear to damage mask integrity and protective function Open
Decontamination of N95 respirators is being used by clinicians in the face of a global shortage of these devices. Some treatments for decontamination, such as some vaporized hydrogen peroxide methods or ultraviolet methods, had no impact o…
View article: Candida auris outbreak involving liver transplant recipients in a surgical intensive care unit
Candida auris outbreak involving liver transplant recipients in a surgical intensive care unit Open
Candida auris is a yeast that is difficult to eradicate and has caused outbreaks in health care facilities. We report a cluster of 5 patients in 1 intensive care unit who were colonized or infected in 2017. The initial 2 patients were reci…
View article: Impact of Changes in Clinical Microbiology Laboratory Location and Ownership on the Practice of Infectious Diseases
Impact of Changes in Clinical Microbiology Laboratory Location and Ownership on the Practice of Infectious Diseases Open
The number of onsite clinical microbiology laboratories in hospitals is decreasing, likely related to the business model for laboratory consolidation and labor shortages, and this impacts a variety of clinical practices, including that of …
View article: 2602. Genetic Basis of Staphylococcus aureus Virulence
2602. Genetic Basis of Staphylococcus aureus Virulence Open
Background Although multiple different virulence factors have been identified for Staphylococcus aureus, there is limited information on genetic variation present between different strains of S. aureus in the clinical setting. To better de…
View article: RE: Preventability of hospital onset bacterermia and fungemia: A pilot study of potential healthcare-associated infection outcome measure, by Dantes et al (2019)
RE: Preventability of hospital onset bacterermia and fungemia: A pilot study of potential healthcare-associated infection outcome measure, by Dantes et al (2019) Open
We read with great interest the article by Dantes et al on the preventability of hospital-onset bacteremias (HOBs) and the use of this metric as a quality outcome measure. In 2017, we also reported a retrospective analysis of the impact of…
View article: ICE volume 40 issue 6 Cover and Front matter
ICE volume 40 issue 6 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: 1070. Epidemiological and Clinical Features of Panton–Valenton Leukocidin-Positive Staphylococcus aureus Bacteremia: A Case–Control Study
1070. Epidemiological and Clinical Features of Panton–Valenton Leukocidin-Positive Staphylococcus aureus Bacteremia: A Case–Control Study Open
Background The presence of the binary Panton-Valentine Leukocidin (PVL) toxin in Staphylococcus aureus has been associated with both severe pneumonia and skin and soft-tissue infections. However, there is only limited data on how this viru…
View article: Impact of elimination of contact precautions on noninfectious adverse events among MRSA and VRE patients
Impact of elimination of contact precautions on noninfectious adverse events among MRSA and VRE patients Open
We read with great interest the article by Martin et al published online in May 2018 in Infection Control and Hospital Epidemiology. We previously reported on the impact of elimination of contact precautions (CP) in methicillin-resistant S…
View article: Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA
Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA Open
The epidemic of illicit intravenous drug use (IVDU) in the United States has been accompanied by a surge in drug overdose deaths and infectious sequelae. Candida albicans infections were associated with injection of contaminated impure bro…
View article: bikedata
bikedata Open
The R package bikedata collates and facilitates access to arguably the world's largest open ongoing dataset on human mobility.All other comparable sources of data (such public transit data, or mobile phone data) are either not publicly ava…
View article: Coronary Artery Calcification (CAC) and Post‐Trial Cardiovascular Events and Mortality Within the Women's Health Initiative (WHI) Estrogen‐Alone Trial
Coronary Artery Calcification (CAC) and Post‐Trial Cardiovascular Events and Mortality Within the Women's Health Initiative (WHI) Estrogen‐Alone Trial Open
Background Among women aged 50 to 59 years at baseline in the Women's Health Initiative (WHI) Estrogen‐Alone (E‐Alone) trial, randomization to conjugated equine estrogen‐alone versus placebo was associated with lower risk of myocardial inf…