Takashi Fujimoto
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View article: Analysis of Bioeconomy–Macroeconomy Linkages
Analysis of Bioeconomy–Macroeconomy Linkages Open
View article: Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid
Antitumor immunostimulatory effect via cell-killing action of a novel extracorporeal blood circulating photodynamic therapy system using 5-aminolevulinic acid Open
This study investigated whether intravenous administration of tumor cells killed by photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA) had antitumor effects on distal tumors. Furthermore, a novel extracorporeal blood circulating…
View article: Association of Serum Soluble T-cadherin Levels with Metabolic Syndrome in Japanese Participants Undergoing Health Checkups
Association of Serum Soluble T-cadherin Levels with Metabolic Syndrome in Japanese Participants Undergoing Health Checkups Open
Low serum 130-kDa sT-cad levels are associated with the presence and accumulation of metabolic syndrome-related abnormalities in a Japanese population undergoing health checkups. Inflammation and lipid abnormalities of metabolic syndrome (…
View article: Clinicopathological Characteristics of Small Intestinal Cancer Associated with Crohn’s Disease
Clinicopathological Characteristics of Small Intestinal Cancer Associated with Crohn’s Disease Open
View article: Conveyor Belt Vibration Analysis Using High-Speed Video Images
Conveyor Belt Vibration Analysis Using High-Speed Video Images Open
This study proposes a novel video-based conveyor monitoring method that can estimate distances between belt-supporting rollers by analyzing belt vibration responses in high-frame-rate (HFR) images. Focusing on the fact that the vibration c…
View article: Anorectal Duplication in Adulthood: A Case Report
Anorectal Duplication in Adulthood: A Case Report Open
View article: Association between serum testosterone changes and parameters of the metabolic syndrome
Association between serum testosterone changes and parameters of the metabolic syndrome Open
Testosterone production is important in males, and various physical and psychological abnormalities occur in individuals with low testosterone levels. In the present study, we aimed to examine the effects of longitudinal changes in total t…
View article: Genetic dissection of <i>HLA-DRB1*15:01</i> and XL9 region variants in Japanese patients with systemic lupus erythematosus: primary role for <i>HLA-DRB1*15:01</i>
Genetic dissection of <i>HLA-DRB1*15:01</i> and XL9 region variants in Japanese patients with systemic lupus erythematosus: primary role for <i>HLA-DRB1*15:01</i> Open
Objective Major histocompatibility complex strongly contributes to susceptibility to systemic lupus erythematosus (SLE). In the European populations, HLA-DRB1*03:01 and DRB1*15:01 are susceptibility alleles, but C4 locus was reported to ac…
View article: Genetic dissection of<i>HLA-DRB1*15:01</i>and XL9 region variants in Japanese patients with systemic lupus erythematosus: Primary role for<i>HLA-DRB1*15:01</i>
Genetic dissection of<i>HLA-DRB1*15:01</i>and XL9 region variants in Japanese patients with systemic lupus erythematosus: Primary role for<i>HLA-DRB1*15:01</i> Open
Objective Major histocompatibility complex strongly contributes to susceptibility to systemic lupus erythematosus (SLE). In the European populations, HLA-DRB1*03:01 and DRB1*15:01 are susceptibility alleles, but C4 locus was reported to ac…
View article: Diverse Approaches to the Study of Agricultural and Forestry Issues: The Sustainable Use of Local Resources in Rural–Urban Fringe; Chairperson’s Address and Summary
Diverse Approaches to the Study of Agricultural and Forestry Issues: The Sustainable Use of Local Resources in Rural–Urban Fringe; Chairperson’s Address and Summary Open
The sustainable use of agricultural resources in the rural–urban fringe was discussed from macro-, micro-, and mezzo- perspectives. From a macro-perspective, Dr. Akita argued that mixed land use between food production and housing, which e…
View article: Heparan sulfate-dependent transport of CCL2 across an in vitro model of the human blood-brain barrier
Heparan sulfate-dependent transport of CCL2 across an in vitro model of the human blood-brain barrier Open
Background: Transport of immune-active substances across the blood-brain barrier (BBB) is an important mechanism of neuroimmune regulation. CCL2 is among the chemokines known to cross the intact BBB in the blood-to-brain direction and is s…
View article: Supplementary materials for the manuscript "Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population"
Supplementary materials for the manuscript "Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population" Open
Supplementary Table S1. Association analysis of each HLA-DRB1 allele with occurrence of relapse and time to relapse. Supplementary Table S2. Association analysis of each HLA-DQA1 allele with occurrence of relapse and tim…
View article: Supplementary materials for the manuscript "Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population"
Supplementary materials for the manuscript "Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population" Open
Supplementary Table S1. Association analysis of each HLA-DRB1 allele with occurrence of relapse and time to relapse. Supplementary Table S2. Association analysis of each HLA-DQA1 allele with occurrence of relapse and tim…
View article: Supplementary materials for the manuscript "Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population"
Supplementary materials for the manuscript "Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population" Open
Supplementary Table S1. Association analysis of each HLA-DRB1 allele with occurrence of relapse and time to relapse. Supplementary Table S2. Association analysis of each HLA-DQA1 allele with occurrence of relapse and tim…
View article: Association of<i>HLA-class II</i>alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population
Association of<i>HLA-class II</i>alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population Open
Background Disease relapse remains a major problem in the management of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In European populations, HLA-DPB1*04:01 is associated with both susceptibility and relapse ris…
View article: Neurotropism and blood-brain barrier involvement in COVID-19
Neurotropism and blood-brain barrier involvement in COVID-19 Open
The global pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persists despite the progress of vaccination and increased natural immunity. SARS-CoV-2 is associated not …
View article: Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation
Transport of the Proinflammatory Chemokines C-C Motif Chemokine Ligand 2 (MCP-1) and C-C Motif Chemokine Ligand 5 (RANTES) across the Intact Mouse Blood-Brain Barrier Is Inhibited by Heparin and Eprodisate and Increased with Systemic Inflammation Open
View article: Lower body mass index potentiates the association between skipping breakfast and prevalence of proteinuria
Lower body mass index potentiates the association between skipping breakfast and prevalence of proteinuria Open
Background Proteinuria is an important predictor of cardiovascular disease and mortality. Several studies reported the association between skipping breakfast and the prevalence of proteinuria. Furthermore, skipping breakfast was associated…
View article: The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples
The Combination of High Levels of Adiponectin and Insulin Resistance Are Affected by Aging in Non-Obese Old Peoples Open
Background Adipokine dysregulation is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Low adiponectin levels are associated with higher risks of cardiovascular diseases (CVD). However, high adiponectin…
View article: Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer
Beyond Lipid-Lowering: Effects of Statins on Cardiovascular and Cerebrovascular Diseases and Cancer Open
The 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known as statins, are administered as first-line therapy for hypercholesterolemia, both as primary and secondary prevention. Besides the lipid-lowering effect, …
View article: Effects of fasudil on blood-brain barrier integrity
Effects of fasudil on blood-brain barrier integrity Open
Background Cerebral infarction accounts for 85% of all stroke cases. Even in an era of rapid and effective recanalization using an intravascular approach, the majority of patients have poor functional outcomes. Thus, there is an urgent nee…
View article: Hematoma expansion unrelated to rebleeding in ruptured anterior cerebral artery aneurysms treated by early endovascular embolization
Hematoma expansion unrelated to rebleeding in ruptured anterior cerebral artery aneurysms treated by early endovascular embolization Open
Background: Whether hematoma expansion after aneurysmal rupture is always a sign of rerupture remains unclear. Hence, the present study aimed to assess the incidence and risk factors of hematoma expansion unrelated to aneurysmal rerupture …
View article: Prolonged Culturing of IPSC-derived Brain Endothelial-like Cells Is Associated With Quiescence, Downregulation of Glycolysis, and Resistance to Disruption by an Alzheimer’s Brain Milieu
Prolonged Culturing of IPSC-derived Brain Endothelial-like Cells Is Associated With Quiescence, Downregulation of Glycolysis, and Resistance to Disruption by an Alzheimer’s Brain Milieu Open
Background: Human induced pluripotent stem cell (hiPSC)-derived brain endothelial-like cells (iBECs) are a robust, scalable, and translatable model of the human blood-brain barrier (BBB). Prior works have shown that high transendothelial e…
View article: Delayed Descending Colon Stenosis for Isolated Inferior Mesenteric Arterial Dissection
Delayed Descending Colon Stenosis for Isolated Inferior Mesenteric Arterial Dissection Open
孤立性腹部内臓動脈解離は比較的まれな疾患で，なかでも大動脈解離を伴わない下腸間膜動脈解離は極めてまれである．今回，我々は孤立性下腸間膜動脈解離による腸管虚血から遅発性に下行結腸に著明な狭窄を来し手術を要した症例を経験したため報告する．症例は68歳の女性で，腹痛・嘔吐・下痢が出現したため近医受診し胃腸炎の診断で帰宅したが，第6病日食事摂取困難となり入院した．脱水・腎前性腎不全・左側結腸炎の診断で絶食・補液などの治療を受けたが，下痢が続くため第50病日に当院へ転院となった．腹部…
View article: Partial Clipping Occlusion Including Rupture Point Is an Effective Strategy for Ruptured Giant Fusiform Basilar Artery Aneurysm: A Technical Case Report
Partial Clipping Occlusion Including Rupture Point Is an Effective Strategy for Ruptured Giant Fusiform Basilar Artery Aneurysm: A Technical Case Report Open
Treatment of fusiform basilar artery aneurysms is still challenging today. The authors present a case of a patient with a ruptured giant fusiform basilar artery aneurysm successfully treated by clipping occlusion of the rupture point. A 62…
View article: A Case of Perforative Peritonitis due to Gangrenous Ischemic Colitis
A Case of Perforative Peritonitis due to Gangrenous Ischemic Colitis Open
壊死型虚血性大腸炎は非常に致死率の高い疾患だが複数の併存疾患があり術前の全身状態も悪い症例に対し集学的治療で救命できた1例を経験したので報告する．
View article: Ischemic Stroke as a Warning Sign of Impending Aneurysmal Rupture: A Report of Two Cases
Ischemic Stroke as a Warning Sign of Impending Aneurysmal Rupture: A Report of Two Cases Open
Ischemic stroke associated with intracranial aneurysm is rare but potentially happens because of emboli originating from aneurysm sac or aneurysmal thrombosis extension to the parent artery. We describe two patients who present subarachnoi…
View article: A Case of Invasive Sphenoid Sinus Aspergillosis Presenting as Oculomotor Nerve Palsy in a Healthy Patient
A Case of Invasive Sphenoid Sinus Aspergillosis Presenting as Oculomotor Nerve Palsy in a Healthy Patient Open
Invasive sphenoid sinus aspergillosis is a rare infection and usually affecting immunocompromised patients. We describe an invasive sphenoid sinus aspergillosis patient with immunocompetent who present progressive ocular dysfunctions. A 66…
View article: New Experiments and Efforts for the Treatment of Anal Fistula
New Experiments and Efforts for the Treatment of Anal Fistula Open
痔瘻の基本術式を大きく分類すると開放術式，括約筋温存術式，シートン法となる．開放術式は根治性は高いが，肛門変形や肛門機能障害のリスクがあるため，より低侵襲な術式として括約筋温存術式が試みられるようになった．括約筋温存術式の再発を完全に無くすことは難しく，根治性を高めるため様々な工夫をこらした術式が考案されている．また痔瘻の手術では基本とされた原発口の処理をしない術式も試みられている．シートン法は機能温存と根治性を兼ね備えた術式であるが，シートン法もまた工夫された術式が報告さ…
View article: Vasospasm and Hydrocephalus Following Subarachnoid Hemorrhage Are Less Frequent in Coil Embolization than in Clipping
Vasospasm and Hydrocephalus Following Subarachnoid Hemorrhage Are Less Frequent in Coil Embolization than in Clipping Open
The multicenter registry study demonstrated lower incidences of both symptomatic vasospasms and NPH in the coiling group than in the clipping group. This superiority may result in better outcomes in the coiling group.