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View article: High-quality chromosome scale genome assemblies of two important Sorghum inbred lines, Tx2783 and RTx436
High-quality chromosome scale genome assemblies of two important Sorghum inbred lines, Tx2783 and RTx436 Open
Sorghum bicolor (L.) Moench is a significant grass crop globally, known for its genetic diversity. High quality genome sequences are needed to capture the diversity. We constructed high-quality, chromosome-level genome assemblies for two v…
View article: eLife assessment: Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors
eLife assessment: Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Methods Data availability References Article and author information Metrics Abstract Extrachromosomal DNA is a common cause of on…
View article: eLife assessment: ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins
eLife assessment: ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Article and author information Metrics Abstract ASARs are a family of very-lon…
View article: eLife Assessment: ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins
eLife Assessment: ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins Open
ASARs are a family of very-long noncoding RNAs that control replication timing on individual human autosomes, and are essential for chromosome stability. The eight known ASAR lncRNAs remain closely associated with their parent chromosomes.…
View article: eLife Assessment: ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins
eLife Assessment: ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins Open
ASARs are a family of very-long noncoding RNAs that control replication timing on individual human autosomes, and are essential for chromosome stability. The eight known ASAR genes express RNAs that remain closely associated with their par…
View article: eLife Assessment: Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors
eLife Assessment: Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors Open
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional …
View article: MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication
MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication Open
Modern maize was domesticated from Teosinte parviglumis , with subsequent introgressions from Teosinte mexicana , yielding increased kernel row number, loss of the hard fruit case and dissociation from the cob upon maturity, as well as few…
View article: eLife Assessment: Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors
eLife Assessment: Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors Open
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional …
View article: The ENCODE Uniform Analysis Pipelines
The ENCODE Uniform Analysis Pipelines Open
The Encyclopedia of DNA elements (ENCODE) project is a collaborative effort to create a comprehensive catalog of functional elements in the human genome. The current database comprises more than 19000 functional genomics experiments across…
View article: eLife Assessment: Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells
eLife Assessment: Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells Open
The protein diversity of mammalian cells is determined by arrays of isoforms from genes. Protein mutation is essential in species evolution and cancer development. Accurate Long-read transcriptome sequencing at single-cell level is require…
View article: Reviewer #3 (Public Review): Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells
Reviewer #3 (Public Review): Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells Open
The protein diversity of mammalian cells is determined by arrays of isoforms from genes. Protein mutation is essential in species evolution and cancer development. Accurate Long-read transcriptome sequencing at single-cell level is require…
View article: Current frontiers in RNA research
Current frontiers in RNA research Open
The biological importance of RNA has expanded as our appreciation of the complexity of its multiple types, structures, chemical compositions and biological roles. Research in RNA has been instrumental in revealing insights into fundamental…
View article: The ENCODE Uniform Analysis Pipelines
The ENCODE Uniform Analysis Pipelines Open
The Encyclopedia of DNA elements (ENCODE) project is a collaborative effort to create a comprehensive catalog of functional elements in the human genome. The current database comprises more than 19000 functional genomics experiments across…
View article: The status of the human gene catalogue
The status of the human gene catalogue Open
Scientists have been trying to identify all of the genes in the human genome since the initial draft of the genome was published in 2001. Over the intervening years, much progress has been made in identifying protein-coding genes, and the …
View article: Ground tissue circuitry regulates organ complexity in maize and <i>Setaria</i>
Ground tissue circuitry regulates organ complexity in maize and <i>Setaria</i> Open
Dyed roots reveal inner complexity Plant roots do so much more than just hold a plant up. As a site for air storage during flooding, mycorrhizal symbiosis, or carbohydrate storage, the more complex root can tap more complicated functions. …