T Hallböök
YOU?
Author Swipe
View article: “Daring to speak of SUDEP” - caregiver and neurologist perspectives on the risk for premature mortality in Dravet Syndrome
“Daring to speak of SUDEP” - caregiver and neurologist perspectives on the risk for premature mortality in Dravet Syndrome Open
Caregivers want to be informed about the risk of premature mortality in DS in a physical meeting, even though it is 'scary'. When the neurologist fails to inform, information is found via other sources. Neurologists may prefer to give verb…
View article: Transitioning from paediatric to adult care in epilepsy: A qualitative study of adolescent experiences
Transitioning from paediatric to adult care in epilepsy: A qualitative study of adolescent experiences Open
Transition in epilepsy is often complex due to the large burden of co-occurring disease, specifically intellectual disability and neuropsychiatric diagnoses. Transfer to adult care is experienced as unplanned and participants experience un…
View article: Autism and attention‐deficit/hyperactivity disorder in children with Dravet syndrome: A population‐based study
Autism and attention‐deficit/hyperactivity disorder in children with Dravet syndrome: A population‐based study Open
Aim To identify on a population basis the prevalence of autism and attention‐deficit/hyperactivity disorder (ADHD) in children with Dravet syndrome and factors associated with symptoms of autism and ADHD. Method Forty‐one of 48 children wi…
View article: Caregiver reported behavior, sleep and quality of life in children with Dravet syndrome: A population-based study
Caregiver reported behavior, sleep and quality of life in children with Dravet syndrome: A population-based study Open
Dravet syndrome in children is associated with significant problems with behavior, sleep and quality of life. There is a need to optimize treatment via ASMs and develop and evaluate interventions to treat behavioral and sleep difficulties …
View article: Epilepsy surgery in patients with hypothalamic hamartomas – Population-based two-year and long-term outcomes
Epilepsy surgery in patients with hypothalamic hamartomas – Population-based two-year and long-term outcomes Open
This study supports surgical treatment of hypothalamic hamartomas as a safe method with a low risk of permanent complications. The seizure reduction seems to be persistent over time.
View article: Method considerations and study protocol for a Nordic multi‐centre prospective study on outcomes in rare paediatric epilepsy surgery subgroups
Method considerations and study protocol for a Nordic multi‐centre prospective study on outcomes in rare paediatric epilepsy surgery subgroups Open
Epilepsy surgery is a therapeutic option for selected children with drug‐resistant epilepsy. Children who are surgical candidates have a high prevalence of neurodevelopmental comorbidities. There is a lack of adequately sized prospective s…
View article: Caregiver reported seizure precipitants and measures to prevent seizures in children with Dravet syndrome
Caregiver reported seizure precipitants and measures to prevent seizures in children with Dravet syndrome Open
Caregiver-reported seizure precipitants are common in DS. Caregivers employ a range of measures to avoid seizures, restricting family life.
View article: Dravet syndrome in children—A population-based study
Dravet syndrome in children—A population-based study Open
A SCN1A variant that could explain the syndrome was found in over 90% of children. Tonic seizures seem to be more frequent than earlier described. Median age at diagnosis was lower, cumulative incidence higher and use of contra-indicated s…
View article: A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies
A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies Open
Objective Clinical care of rare and complex epilepsies is challenging, because evidence‐based treatment guidelines are scarce, the experience of many physicians is limited, and interdisciplinary treatment of comorbidities is required. The …
View article: Cortical excitability measured with transcranial magnetic stimulation in children with epilepsy before and after antiepileptic drugs
Cortical excitability measured with transcranial magnetic stimulation in children with epilepsy before and after antiepileptic drugs Open
Aim To evaluate cortical excitability with transcranial magnetic stimulation (TMS) in children with new‐onset epilepsy before and after antiepileptic drugs (AEDs). Method Fifty‐five drug‐naïve patients (29 females, 26 males; 3–18y), with n…
View article: Potassium citrate and metabolic acidosis in children with epilepsy on the ketogenic diet: a prospective controlled study
Potassium citrate and metabolic acidosis in children with epilepsy on the ketogenic diet: a prospective controlled study Open
Aim To investigate if potassium citrate, a mild alkaline compound, can prevent metabolic acidosis in children with epilepsy treated with the ketogenic diet without reducing antiepileptic efficacy. Method In this prospective controlled stud…
View article: Corrigendum: Altered Brain Microstate Dynamics in Adolescents With Narcolepsy
Corrigendum: Altered Brain Microstate Dynamics in Adolescents With Narcolepsy Open
[This corrects the article DOI: 10.3389/fnhum.2016.00369.].
View article: Unexpected Fat Distribution in Adolescents With Narcolepsy
Unexpected Fat Distribution in Adolescents With Narcolepsy Open
Narcolepsy type 1 is a chronic sleep disorder with significantly higher BMI reported in more than 50% of adolescent patients, putting them at a higher risk for metabolic syndrome in adulthood. Although well-documented, the body fat distrib…
View article: The development of a health-related quality-of-life instrument for young people with narcolepsy: NARQoL-21
The development of a health-related quality-of-life instrument for young people with narcolepsy: NARQoL-21 Open
Establishing the validity of a disease-specific HrQoL instrument in a population of people with a rare condition poses significant challenges. The mixed-methods approach adopted here has resulted in a questionnaire of 21 items with good di…
View article: Ketogenic diet in pyruvate dehydrogenase complex deficiency: short‐ and long‐term outcomes
Ketogenic diet in pyruvate dehydrogenase complex deficiency: short‐ and long‐term outcomes Open
Objectives Our aime was to study the short‐ and long‐term effects of ketogenic diet on the disease course and disease‐related outcomes in patients with pyruvate dehydrogenase complex deficiency, the metabolic factors implicated in treatmen…
View article: Altered Brain Microstate Dynamics in Adolescents with Narcolepsy
Altered Brain Microstate Dynamics in Adolescents with Narcolepsy Open
Narcolepsy is a chronic sleep disorder caused by a loss of hypocretin-1 producing neurons in the hypothalamus. Previous neuroimaging studies have investigated brain function in narcolepsy during rest using positron emission tomography (PET…
View article: Neuronal Antibodies in Children with or without Narcolepsy following H1N1-AS03 Vaccination
Neuronal Antibodies in Children with or without Narcolepsy following H1N1-AS03 Vaccination Open
Type 1 narcolepsy is caused by deficiency of hypothalamic orexin/hypocretin. An autoimmune basis is suspected, but no specific antibodies, either causative or as biomarkers, have been identified. However, the AS03 adjuvanted split virion H…
View article: Psychiatric Comorbidity and Cognitive Profile in Children with Narcolepsy with or without Association to the H1N1 Influenza Vaccination
Psychiatric Comorbidity and Cognitive Profile in Children with Narcolepsy with or without Association to the H1N1 Influenza Vaccination Open
Our study indicates increased psychiatric comorbidity in children and adolescents with narcolepsy. The identified cognitive profile with significantly lower verbal comprehension and working memory compared with the normal mean index could …
View article: Dravet syndrome in Sweden: a population‐based study
Dravet syndrome in Sweden: a population‐based study Open
Aim To assess the prevalence and incidence of Dravet syndrome in children diagnosed in Sweden between 2007 and 2011, and to describe neurological comorbidity, disease course, phenotypes, and treatment effects. Method All neuropaediatrician…