Explanipedia

Association between individual cow factors and udder cleft dermatitis in dairy cows Open

Rubén Garrido, Amy Gillespie, Dai Grove‐White, R. L. Ridgway, Kevin Ogden , et al. · 2025

Udder cleft dermatitis (UCD) is a skin condition affecting dairy cows, manifesting between the udder halves or at the fore attachment of the udder to the abdominal wall. Although several studies have investigated UCD in recent years, its p…

Evaluation of milking performance following 2 different teat-preparation routines Open

Helen Williams, Dai Grove‐White, R. L. Ridgway, Niall Connolly, R Puentes-Garrido , et al. · 2025

The aim of this study was to investigate whether the use of an iodine-based predip solution and paper towel (dip routine) reduces the incidence of delayed milk ejection and the recorded vacuum at the teat end, compared with a proprietary t…

WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts’ Activation and Collagen Processing Open

Ze Li, Helen Williams, Molly L. Jackson, Jason L. Johnson, Sarah J. George · 2024

Hypertension induces cardiac fibrotic remodelling characterised by the phenotypic switching of cardiac fibroblasts (CFs) and collagen deposition. We tested the hypothesis that Wnt1-inducible signalling pathway protein-1 (WISP-1) promotes C…

Pharmacological Inhibition of MMP-12 Exerts Protective Effects on Angiotensin II-Induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice Open

Karina Di Gregoli, Georgia Atkinson, Helen Williams, Sarah J. George, Jason L. Johnson · 2024

Human abdominal aortic aneurysms (AAAs) are characterized by increased activity of matrix metalloproteinases (MMP), including MMP-12, alongside macrophage accumulation and elastin degradation, in conjunction with superimposed atheroscleros…

Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice Open

Lien M. Reolizo, Helen Williams, Kerry S. Wadey, Aleksandra Frankow, Ze Li , et al. · 2023

Background: Late vein graft failure is caused by intimal thickening resulting from endothelial cell (EC) damage and inflammation which promotes vascular smooth muscle cell (VSMC) dedifferentiation, migration, and proliferation. Nonphosphor…

Socioeconomic status and perioperative risk. Comment on Br J Anaesth 2021; 126:642-51 Open

Helen Williams, Iain Moppett · 2021

The article is available via Open Access. Click on the 'Additional link' above to access the full-text.

Aneurysm severity is suppressed by deletion of CCN4 Open

Helen Williams, Kerry S. Wadey, Aleksandra Frankow, Hazel Blythe, Tessa Forbes , et al. · 2021

Patients with abdominal aortic aneurysms are frequently treated with high-risk surgery. A pharmaceutical treatment to reverse aneurysm progression could prevent the need for surgery and save both lives and healthcare resources. Since CCN4 …

Improving Transplant Opportunities for Patients who are Sensitized (ITOPS): Protocol for a Feasibility, Randomized, Controlled, Phase III Clinical Trial Open

Siân Griffin, Tracey Rees, Samaher Sweity, Helen Williams, Laura Pankhurst , et al. · 2020

• Background: Kidney transplantation offers a better quality of life and a clear survival advantage compared to long-term dialysis. However, rates of transplantation are low for highly sensitized patients (HSP) who have a broad specificity…

Repeatability and Feasibility of Pressure Algometry for Quantifying Mechanical Nociceptive Threshold in the Thoracic Region of Calves Open

Helen Williams, Jennifer Duncan, Dai Grove‐White, Philippa Jane Mahen, Amy Gillespie · 2020

Pressure algometry can be used to quantify mechanical nociceptive threshold (MNT) in humans and animals. If reliable this may be a useful tool to examine calves for increased mechanical sensitivity, which may be induced by disease or pain.…

Ovine infectious keratoconjunctivitis in sheep: the farmer's perspective Open

Helen Williams, Jennifer Duncan, Sarah Nichol Fisher, Amy Coates, Jessica E. Stokes , et al. · 2019

The objective of this study was to gather current, farmer‐reported data on the frequency of occurrence, risk factors and treatment practices for the sheep eye disease, ovine infectious keratoconjunctivitis (OIKC). A questionnaire regarding…

Interactions between extracellular Hsp72 and blood cells Open

Helen Williams · 2019

Aging differentially modulates the Wnt pro‐survival signalling pathways in vascular smooth muscle cells Open

Bethan A. Brown, Georgia May Connolly, Carina Mill, Helen Williams, Gianni D. Angelini , et al. · 2018

We previously reported pro‐survival effects of Wnt3a and Wnt5a proteins in vascular smooth muscle cells (VSMCs). Wnt5a achieved this through induction of Wnt1‐inducible signalling pathway protein‐1 (WISP‐1) consequent to β‐catenin/CREB‐dep…

Effect of blood ionised calcium concentration at calving on fertility outcomes in dairy cattle Open

Philippa Jane Mahen, Helen Williams, Robert F. Smith, David Hugh Grove-White · 2018

Clinical and subclinical hypocalcaemia are common in dairy cows, yet evidence in the literature assessing their impact on fertility is inconsistent. The aim of this prospective cohort study was to examine associations between blood ionised…

A highly stable blood meal alternative for rearing Aedes and Anopheles mosquitoes Open

Ted A. Baughman, Chelsea Peterson, Corrie Ortega, Sarah R. Preston, Christopher J. Paton , et al. · 2017

We investigated alternatives to whole blood for blood feeding of mosquitoes with a focus on improved stability and compatibility with mass rearing programs. In contrast to whole blood, an artificial blood diet of ATP-supplemented plasma wa…

Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression Open

Cressida A. Lyon, Helen Williams, Rosaria Bianco, Steven J. Simmonds, Bethan A. Brown , et al. · 2017

Targeting Wnt/β-Catenin Activated Cells with Dominant-Negative N-cadherin to Reduce Neointima Formation Open

Sarah L. Hulin-Curtis, Helen Williams, Kerry S. Wadey, Graciela B. Sala‐Newby, Sarah J. George · 2017

The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae Open

Zatul-’Iffah Abu Hasan, Helen Williams, Nur M. Ismail, Hidayatulfathi Othman, Gyles E. Cozier , et al. · 2017

Isolated Hypoglossal Nerve Palsy: A Case Report Open

Sarah Jayne Campbell, Helen Williams, Lino Locurcio, Alex Creedon · 2017

We report an isolated unilateral hypoglossal nerve palsy in a 59 year old gentleman. Following thorough investigation it became apparent that this was the first presentation of widespread metastasis. Our report emphasizes the importance of…

Suppression of neointima formation by targeting β-catenin/TCF pathway Open

Helen Williams, Sadie C. Slater, Sarah J. George · 2016

Coronary artery disease is treated by vein grafting and stent implantation. Late vein graft failure and restenosis of stented arteries reduce the success rates of these approaches and are caused by neointima formation. We have previously s…

Whole‐flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial Open

J. W. Angell, Dai Grove‐White, Helen Williams, Jennifer Duncan · 2016

The aim of this study was to evaluate the clinical success of whole‐flock systemic tilmicosin and enhanced biosecurity in eliminating active contagious ovine digital dermatitis (CODD) from sheep flocks. Thirty flocks in the UK were randoml…

Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration Open

Helen Williams, Carina A.E. Mill, B.A. Monk, Sarah L. Hulin-Curtis, Jason L. Johnson , et al. · 2016

Objective— Increased vascular smooth muscle cell (VSMC) migration leads to intimal thickening which acts as a soil for atherosclersosis, as well as causing coronary artery restenosis after stenting and vein graft failure. Investigating fac…

Prenatal central nervous system anomaly with skeletal dysplasia associated with a <i>de novo</i> interstitial tandem triplication of chromosome 14 Open

Georgina K. Hall, Fiona L. Mackie, Helen Williams, Denise Williams, P. Cox , et al. · 2016

Prenatal central nervous system anomaly with skeletal dysplasia associated with a de novo interstitial tandem triplication of chromosome 14

Answers to Epilogue questions: An unusual case of abdominal distension with constipation Open

Pooja Popat, Helen Williams, Ian Wacogne, Ingo Jester, Sílvia Planas , et al. · 2015

1. Figure 1 shows an abnormal bowel gas distribution with central paucity, and the impression that bowel is displaced into the upper abdomen. 2. Figure 2 shows a large fluid-filled mass occupying most of the central abdomen but not exte…

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