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View article: The Contradiction of Institutional Diversity in the Design Student Body
The Contradiction of Institutional Diversity in the Design Student Body Open
The United States of America has pioneered initiatives, policies, and pedagogies to diversify its higher education student bodies. In design education, for instance, students are taught to self-represent their cultures and those of their a…
View article: Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of <i>bla</i> KPC-carbapenemase-producing Enterobacterales in a hospital setting
Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of <i>bla</i> KPC-carbapenemase-producing Enterobacterales in a hospital setting Open
Background Healthcare-associated wastewater and asymptomatic patient reservoirs colonized by carbapenemase-producing Enterobacterales (CPE) contribute to nosocomial CPE dissemination, but the characteristics and dynamics of this remain unc…
View article: Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK Open
Background To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used fo…
View article: Routine, molecular point-of-care testing for SARS-CoV-2 and other respiratory viruses within an acute oncology service improves patient care
Routine, molecular point-of-care testing for SARS-CoV-2 and other respiratory viruses within an acute oncology service improves patient care Open
View article: Epidemiological connectivity between humans and animals across an urban landscape
Epidemiological connectivity between humans and animals across an urban landscape Open
Urbanization is predicted to be a key driver of disease emergence through human exposure to novel, animal-borne pathogens. However, while we suspect that urban landscapes are primed to expose people to novel animal-borne diseases, evidence…
View article: Highlights of the NCCN Oncology Research Program
Highlights of the NCCN Oncology Research Program Open
View article: A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort
A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort Open
Background The success of early dexamethasone therapy for hospitalised COVID-19 cases in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action against a hyperinflammation (HI) response. It is likely that …
View article: Satellite continuous-variable quantum key distribution systems using code-division multiple access
Satellite continuous-variable quantum key distribution systems using code-division multiple access Open
In this paper, we propose a novel architecture of the satellite continuous-variable quantum key distribution (CV-QKD) system that can not only support multiple users but also enhance the security. The satellite CV-QKD system is based on a …
View article: Evidence of a genetically driven metabolomic signature in actively inflamed Crohn’s disease
Evidence of a genetically driven metabolomic signature in actively inflamed Crohn’s disease Open
View article: Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset
Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset Open
View article: P954: ESTABLISHING THE NATIONAL INSTITUTE FOR HEALTH RESEARCH (NIHR) HEALTH INFORMATICS COLLABORATIVE (HIC) MULTIPLE MYELOMA (MM) REGISTRY
P954: ESTABLISHING THE NATIONAL INSTITUTE FOR HEALTH RESEARCH (NIHR) HEALTH INFORMATICS COLLABORATIVE (HIC) MULTIPLE MYELOMA (MM) REGISTRY Open
Background: Real world data provides unique insights into the natural history of MM, resource utilisation, adherence to standards and outcomes of treatments outside clinical trials. However, the quality of such initiatives can be poor due …
View article: FebriDx host response point-of-care testing improves patient triage for coronavirus disease 2019 (COVID-19) in the emergency department – ADDENDUM
FebriDx host response point-of-care testing improves patient triage for coronavirus disease 2019 (COVID-19) in the emergency department – ADDENDUM Open
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View article: Population genomics of Escherichia coli in livestock-keeping households across a rapidly developing urban landscape
Population genomics of Escherichia coli in livestock-keeping households across a rapidly developing urban landscape Open
Quantitative evidence for the risk of zoonoses and the spread of antimicrobial resistance remains lacking. Here, as part of the UrbanZoo project, we sampled Escherichia coli from humans, livestock and peri-domestic wildlife in 99 household…
View article: Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK Open
Background: To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarkers used f…
View article: Biomarker identification using dynamic time warping analysis: a longitudinal cohort study of patients with COVID-19 in a UK tertiary hospital
Biomarker identification using dynamic time warping analysis: a longitudinal cohort study of patients with COVID-19 in a UK tertiary hospital Open
Objectives COVID-19 is a heterogeneous disease, and many reports have described variations in demographic, biochemical and clinical features at presentation influencing overall hospital mortality. However, there is little information regar…
View article: FebriDx host response point-of-care testing improves patient triage for coronavirus disease 2019 (COVID-19) in the emergency department
FebriDx host response point-of-care testing improves patient triage for coronavirus disease 2019 (COVID-19) in the emergency department Open
Objectives: Patients presenting to hospital with suspected coronavirus disease 2019 (COVID-19), based on clinical symptoms, are routinely placed in a cohort together until polymerase chain reaction (PCR) test results are available. This pr…
View article: Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of bla<sub>KPC</sub>-carbapenemase-producing Enterobacterales in a hospital setting
Genomic epidemiology and longitudinal sampling of ward wastewater environments and patients reveals complexity of the transmission dynamics of bla<sub>KPC</sub>-carbapenemase-producing Enterobacterales in a hospital setting Open
2. Abstract Healthcare-associated wastewater reservoirs and asymptomatic gastrointestinal patient colonisation by carbapenemase-producing Enterobacterales (CPE) contribute to nosocomial CPE dissemination. We systematically sampled wastewat…
View article: Wave comparisons of clinical characteristics and outcomes of COVID-19 admissions - Exploring the impact of treatment and strain dynamics
Wave comparisons of clinical characteristics and outcomes of COVID-19 admissions - Exploring the impact of treatment and strain dynamics Open
View article: Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK Open
Background and aims To determine the impact of the COVID-19 pandemic on the population with chronic Hepatitis B virus (HBV) infection under hospital follow-up in the UK, we quantified the coverage and frequency of measurements of biomarker…
View article: PTU-32 Natural Language Processing Driven Comparison of Small Bowel MRI and Capsule Endoscopy Reporting for Crohn’s
PTU-32 Natural Language Processing Driven Comparison of Small Bowel MRI and Capsule Endoscopy Reporting for Crohn’s Open
Introduction Small Bowel Capsule Endoscopy (SBCE) has an established role in the diagnosis/management of small bowel Crohn's disease (CD). Previous work has suggested its diagnostic yield is comparable to that of Small Bowel MRI (SBMR), bu…
View article: PTH-36 Identification & Service Evaluation of a Primary Sclerosing Cholangitis Cohort using Natural Language Processing
PTH-36 Identification & Service Evaluation of a Primary Sclerosing Cholangitis Cohort using Natural Language Processing Open
Introduction: primary sclerosing cholangitis (PSC) is a rare and difficult to treat condition. PSC is strongly associated with malignancy, therefore screening and surveillance are paramount. PSC however does not have a unique UK ICD-10 dia…
View article: Cohort Profile: National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) Research Dataset
Cohort Profile: National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) Research Dataset Open
Purpose The National Institute for Health Research (NIHR) Health Informatics Collaborative (HIC) was established to enable re-use of routinely collected clinical data across National Health Service (NHS) Trusts in the United Kingdom to sup…
View article: Secondary haemophagocytic lymphohistiocytosis in hospitalised COVID-19 patients as indicated by a modified HScore is infrequent and high scores do not associate with increased mortality
Secondary haemophagocytic lymphohistiocytosis in hospitalised COVID-19 patients as indicated by a modified HScore is infrequent and high scores do not associate with increased mortality Open
View article: SARS-CoV-2 viral load at presentation to hospital is independently associated with the risk of death
SARS-CoV-2 viral load at presentation to hospital is independently associated with the risk of death Open
View article: A novel hyperinflammation clinical risk tool, HI5-NEWS2, predicts mortality following early dexamethasone use in an observational cohort of hospitalised COVID-19 patients
A novel hyperinflammation clinical risk tool, HI5-NEWS2, predicts mortality following early dexamethasone use in an observational cohort of hospitalised COVID-19 patients Open
Background The success of early dexamethasone therapy for hospitalised COVID-19 cases in treatment of Sars-CoV-2 infection may predominantly reflect its anti-inflammatory action against a hyperinflammation (HI) response. It is likely that …
View article: Asthma did not increase in‐hospital COVID‐19‐related mortality in a tertiary UK hospital
Asthma did not increase in‐hospital COVID‐19‐related mortality in a tertiary UK hospital Open
Asthma is the most prevalent chronic inflammatory respiratory disease worldwide affecting one in twelve adults (8.3%) in the United Kingdom (UK) (1). Coronavirus disease 2019 (Covid-19) has afflicted at least 80.3 million patients worldwid…
View article: S3 Comparisons in early and late presentation to hospital in COVID-19 patients
S3 Comparisons in early and late presentation to hospital in COVID-19 patients Open
Background The clinical presentation and disease severity in SARS-Cov-2 infection ranges from asymptomatic carriage to death. There is little data regarding the timeframe of symptom onset to presentation to hospital, and disease outcomes. …
View article: Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study
Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study Open
View article: Additional file 4 of Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study
Additional file 4 of Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study Open
Additional file 4: Table S4. Internally validated discrimination for KCH training sample based on nested repeated cross-validation.
View article: Additional file 1 of Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study
Additional file 1 of Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study Open
Additional file 1: Table S1. SNOMED terms.