Thomas Benfield
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View article: Diagnostic performance of upper airway sampling sites for SARS-CoV-2 and influenza testing
Diagnostic performance of upper airway sampling sites for SARS-CoV-2 and influenza testing Open
Early diagnosis of upper respiratory infections is essential to control infectious disease transmission within the community and to initiate relevant antiviral treatments. Nonetheless, variable sensitivities of sampling sites are often ove…
View article: Danish Medical Journal og kontroverser i medicin
Danish Medical Journal og kontroverser i medicin Open
View article: Circulating HBV RNA and hepatitis B core-related antigen as determinants of HBsAg loss in persons with HIV in Europe
Circulating HBV RNA and hepatitis B core-related antigen as determinants of HBsAg loss in persons with HIV in Europe Open
View article: Adding a tonsil specimen to a throat swab does not improve the detection rate of SARS-CoV-2 – a multicenter randomized controlled trial
Adding a tonsil specimen to a throat swab does not improve the detection rate of SARS-CoV-2 – a multicenter randomized controlled trial Open
Including the palatine tonsils in throat swabs does not increase the detection rate for SARS-CoV-2, but is associated with more discomfort compared to throat swabs avoiding the palatine tonsils.
View article: The use of macrolides in the treatment of community-acquired pneumonia: risks and benefits
The use of macrolides in the treatment of community-acquired pneumonia: risks and benefits Open
This Journal club aims to evaluate the recent evidence about the potential benefits of macrolides as add-on therapy in the treatment of community-acquired pneumonia (CAP), an area where the data remain conflicting. Four studies with divers…
View article: No changes in weight, body composition or metabolic parameters after the switch to dolutegravir and lamivudine compared to continued treatment with dolutegravir, abacavir and lamivudine for virologically suppressed HIV infection (The AVERTAS trial)
No changes in weight, body composition or metabolic parameters after the switch to dolutegravir and lamivudine compared to continued treatment with dolutegravir, abacavir and lamivudine for virologically suppressed HIV infection (The AVERTAS trial) Open
Continuing or discontinuing abacavir for 48 weeks was associated with modest gains in weight that did not differ between groups. Similarly, fat distribution, or metabolic parameters were comparable between groups.
View article: Impact of pneumococcal urinary antigen testing on clinical outcomes in patients hospitalized with community-acquired pneumonia
Impact of pneumococcal urinary antigen testing on clinical outcomes in patients hospitalized with community-acquired pneumonia Open
View article: Hyperglycemia and insulin use in patients with COVID-19 and severe hypoxemia allocated to 12 mg vs. 6 mg of dexamethasone: a secondary analysis of the COVID STEROID 2 randomized trial
Hyperglycemia and insulin use in patients with COVID-19 and severe hypoxemia allocated to 12 mg vs. 6 mg of dexamethasone: a secondary analysis of the COVID STEROID 2 randomized trial Open
View article: Recovery of lung function during the first year after COVID-19: a systematic review and meta-analysis
Recovery of lung function during the first year after COVID-19: a systematic review and meta-analysis Open
Background Several studies have reported lung function impairment following COVID-19. Less is known about the subsequent recovery. Research question What is the recovery in lung function after COVID-19 during the first year after infection…
View article: Retraction Note: A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA
Retraction Note: A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA Open
View article: Incidence of Confirmed Influenza and Pneumococcal Infections and Vaccine Uptake Among Virologically Suppressed People Living with HIV
Incidence of Confirmed Influenza and Pneumococcal Infections and Vaccine Uptake Among Virologically Suppressed People Living with HIV Open
Background/Objectives: Influenza and Streptococcus pneumoniae infections are common vaccine-preventable diseases to which people living with HIV (PLWH) may be more susceptible. This study aims to investigate the incidence of confirmed infl…
View article: Overvågning og forebyggelse af pneumokoksygdom – kan vi gøre det bedre?
Overvågning og forebyggelse af pneumokoksygdom – kan vi gøre det bedre? Open
View article: Association Between hsTnT and NT-proBNP and Peripheral Artery Disease in People with HIV: A Multicentre Danish Cohort Study
Association Between hsTnT and NT-proBNP and Peripheral Artery Disease in People with HIV: A Multicentre Danish Cohort Study Open
People with HIV (PWH) have a high risk of peripheral artery disease (PAD), and high-sensitivity troponin (hsTnT) and NT-pro B-type natriuretic peptide (NT-proBNP) may be useful biomarkers for PAD in PWH. We assessed associations between hs…
View article: Socioeconomic disparities in long COVID diagnosis among ethnic minorities in Denmark
Socioeconomic disparities in long COVID diagnosis among ethnic minorities in Denmark Open
These findings highlight the need to address ethnic disparities in long COVID, particularly among migrants with low income. Workplace interventions and policies targeting work-related vulnerabilities could help reduce the disproportionate …
View article: Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission <i>Ex Vivo</i>
Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission <i>Ex Vivo</i> Open
Risk stratification using multi‐omics data deepens understanding of immunometabolism in successfully treated people with HIV (PWH) is inadequately explained. A personalized medicine approach integrating blood cell transcriptomics, plasma p…
View article: Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments
Differences in biomarker levels and proteomic survival prediction across two COVID-19 cohorts with distinct treatments Open
Prognostic biomarkers have been widely studied in COVID-19, but their levels may be influenced by treatment strategies. This study examined plasma biomarkers and proteomic survival prediction in two unvaccinated hospitalized COVID-19 cohor…
View article: Cytomegalovirus Antibodies and Coronary Artery Disease in People with HIV: A Cohort Study
Cytomegalovirus Antibodies and Coronary Artery Disease in People with HIV: A Cohort Study Open
People with HIV (PWH) have a high risk of coronary artery disease (CAD). Cytomegalovirus (CMV) co-infection is very common in PWH, but little is known about its association with CAD. We aimed to investigate if CMV IgG serostatus and concen…
View article: Long COVID and its risk factors in migrants: a nationwide register study from Sweden
Long COVID and its risk factors in migrants: a nationwide register study from Sweden Open
Background Many studies have found more severe COVID-19 outcomes in migrants and ethnic minorities throughout the COVID-19 pandemic, while recent evidence also suggests higher risk of longer-term consequences. We studied the risk of a long…
View article: Disrupted α-ketoglutarate homeostasis trains monocyte-derived macrophages towards M2-like phenotype in long-term treated HIV-infection
Disrupted α-ketoglutarate homeostasis trains monocyte-derived macrophages towards M2-like phenotype in long-term treated HIV-infection Open
Cells of the myeloid lineage, particularly monocytes and macrophages, play a key role in HIV infection by contributing to viral replication, immune response, and maintaining immune balance during suppressive therapy. We hypothesized that m…
View article: Mod større gennemsigtighed: Ugeskrift for Læger styrker fokus på interessekonflikter
Mod større gennemsigtighed: Ugeskrift for Læger styrker fokus på interessekonflikter Open
View article: Susceptibility to and severity of SARS-CoV-2 infection according to prescription drug use–an observational study of 46,506 Danish healthcare workers
Susceptibility to and severity of SARS-CoV-2 infection according to prescription drug use–an observational study of 46,506 Danish healthcare workers Open
It is not well investigated whether exposure to specific drug classes is associated with COVID-19. We investigated the risk of SARS-CoV-2 infection and severe COVID-19 among healthcare workers according to prescription drug use. We conduct…
View article: Experiences of access to care, diagnosis and rehabilitation among a multiethnic patient population with long-COVID in Denmark
Experiences of access to care, diagnosis and rehabilitation among a multiethnic patient population with long-COVID in Denmark Open
Background and aim The aim of the study was to explore the experiences of accessing care, diagnosis, and rehabilitation among patients with long-COVID in a multiethnic population in Denmark. Methods Qualitative research using semi-structur…
View article: Risk of long COVID and associated symptoms after acute SARS-COV-2 infection in ethnic minorities: a Danish nationwide cohort study
Risk of long COVID and associated symptoms after acute SARS-COV-2 infection in ethnic minorities: a Danish nationwide cohort study Open
Background and aim Ethnic minorities living in high-income countries have been disproportionately affected by COVID-19 in terms of infection rates, hospitalisations, and deaths; however, less is known about long COVID in these populations.…
View article: Ethnic disparities in clinical severity of COVID-19 as predictor of long COVID
Ethnic disparities in clinical severity of COVID-19 as predictor of long COVID Open
Background Recent studies from Europe have shown a higher incidence of long COVID among ethnic minorities compared to the majority population. Little is known of these disparities, but they might be related to factors such as COVID-19 dise…
View article: Clinical Manifestations and Outcomes in Adults Hospitalized With Respiratory Syncytial Virus and Influenza a/B: A Multicenter Observational Cohort Study
Clinical Manifestations and Outcomes in Adults Hospitalized With Respiratory Syncytial Virus and Influenza a/B: A Multicenter Observational Cohort Study Open
Background Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adu…
View article: Reassessing Halm's clinical stability criteria in community-acquired pneumonia management
Reassessing Halm's clinical stability criteria in community-acquired pneumonia management Open
Background Halm's clinical stability criteria have long guided antibiotic treatment and hospital discharge decisions for patients hospitalised with community-acquired pneumonia (CAP). Originally introduced in 1998, these criteria were esta…
View article: Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults
Endothelial injury and decline in lung function in persons living with HIV: a prospective Danish cohort study including 698 adults Open
Objectives Endothelial injury may promote declining lung function. We aimed to investigate in well-treated persons living with HIV (PLWH) whether elevated levels of thrombomodulin (TM) and syndecan-1 (SDC1) are associated with excess lung …
View article: Higher levels of IL-1ra, IL-6, IL-8, MCP-1, MIP-3α, MIP-3β, and fractalkine are associated with 90-day mortality in 132 non-immunomodulated hospitalized patients with COVID-19
Higher levels of IL-1ra, IL-6, IL-8, MCP-1, MIP-3α, MIP-3β, and fractalkine are associated with 90-day mortality in 132 non-immunomodulated hospitalized patients with COVID-19 Open
Introduction Immune dysregulation with an excessive release of cytokines has been identified as a key driver in the development of severe COVID-19. The aim of this study was to evaluate the initial cytokine profile associated with 90-day m…
View article: Kønsfordelingen blandt korresponderende forfattere i Ugeskrift for Læger – rimelig med plads til forbedring
Kønsfordelingen blandt korresponderende forfattere i Ugeskrift for Læger – rimelig med plads til forbedring Open
View article: Endogenous serum glucocorticoid concentrations, steroidogenic enzyme activity, and 90-day mortality in patients hospitalized with COVID-19: an observational cohort study
Endogenous serum glucocorticoid concentrations, steroidogenic enzyme activity, and 90-day mortality in patients hospitalized with COVID-19: an observational cohort study Open
In the context of severe coronavirus disease 2019 (COVID-19) illness, we examined endogenous glucocorticoid concentrations, steroidogenic enzyme activity, and their correlation with inflammation and patient outcomes. This observational stu…