T. Lynne Blasius
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View article: Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation
Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation Open
Microtubules are cytoskeletal filaments that self-assemble from the protein tubulin, a heterodimer of α-tubulin and β-tubulin, and are important for cell mechanics, migration, and division. Much work has focused on how the nucleotide state…
View article: Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation
Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation Open
Microtubules are cytoskeletal filaments that self-assemble from the protein tubulin, a heterodimer of α-tubulin and β-tubulin, and are important for cell mechanics, migration, and division. Much work has focused on how the nucleotide state…
View article: Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation
Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation Open
Microtubules are cytoskeletal filaments that self-assemble from the protein tubulin, a heterodimer of α-tubulin and β-tubulin, and are important for cell mechanics, migration, and division. Much work has focused on how the nucleotide state…
View article: The Kinesin-3 KIF1A Functions as a Diligent Worker during Axonal Transport
The Kinesin-3 KIF1A Functions as a Diligent Worker during Axonal Transport Open
Long-distance intracellular transport is driven by motor proteins that walk along microtubule tracks. The fate of the motor protein after transport is unclear. Classically, motor proteins have been thought to function as Diligent Workers (…
View article: Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons
Mechanistic Analysis of CCP1 in Generating ΔC2 α-Tubulin in Mammalian Cells and Photoreceptor Neurons Open
An important post-translational modification (PTM) of α-tubulin is the removal of amino acids from its C-terminus. Removal of the C-terminal tyrosine residue yields detyrosinated α-tubulin, and subsequent removal of the penultimate glutama…
View article: A kinesin-1 variant reveals motor-induced microtubule damage in cells
A kinesin-1 variant reveals motor-induced microtubule damage in cells Open
View article: Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7’s microtubule binding
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7’s microtubule binding Open
Hedgehog pathway activation results in accumulation of kinesin-4 KIF7 and Gli transcription factors at the tip of the primary cilium. This article shows that intraflagellar transport driven by heterotrimeric kinesin-2 is required for KIF7’…
View article: A kinesin-1 variant reveals motor-induced microtubule damage in cells
A kinesin-1 variant reveals motor-induced microtubule damage in cells Open
Kinesins drive the transport of cellular cargoes as they walk along microtubule tracks, however, recent work has suggested that the physical act of kinesins walking along microtubules can stress the microtubule lattice. Here, we describe a…
View article: Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin
Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin Open
View article: Microtubule binding of the kinesin-4 KIF7 and its regulation by autoinhibition
Microtubule binding of the kinesin-4 KIF7 and its regulation by autoinhibition Open
KIF7 is a member of the kinesin-4 family and plays critical roles in Hedgehog signaling in vertebrate cells. KIF7 is an atypical kinesin as it binds to microtubules but is immotile. We demonstrate that, like conventional kinesins, KIF7 is …
View article: Analysis of the Motility Properties of the Kinesin-4 Familiy Members KIF7 and KIF27
Analysis of the Motility Properties of the Kinesin-4 Familiy Members KIF7 and KIF27 Open
View article: Engineering Inhibitable Kinesin-3 Motors by a Novel Chemical-Genetic Approach
Engineering Inhibitable Kinesin-3 Motors by a Novel Chemical-Genetic Approach Open
View article: Engineered kinesin motor proteins amenable to small-molecule inhibition
Engineered kinesin motor proteins amenable to small-molecule inhibition Open
View article: Engineered kinesin motor proteins amenable to small molecule inhibition
Engineered kinesin motor proteins amenable to small molecule inhibition Open
The human genome encodes 45 kinesins that drive cell division, cell motility, intracellular trafficking, and ciliary function. Determining the cellular function of each kinesin would be greatly facilitated by specific small molecule inhibi…
View article: Dual Chromatin and Cytoskeletal Remodeling by SETD2
Dual Chromatin and Cytoskeletal Remodeling by SETD2 Open
Posttranslational modifications (PTMs) of tubulin specify microtubules for specialized cellular functions and comprise what is termed a "tubulin code." PTMs of histones comprise an analogous "histone code," although the "readers, writers, …