Markus Juonala
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View article: Associations of long-term cumulative C-reactive protein and glycoprotein acetyls concentrations in childhood, adolescence and adulthood with adulthood retinal microvascular structure
Associations of long-term cumulative C-reactive protein and glycoprotein acetyls concentrations in childhood, adolescence and adulthood with adulthood retinal microvascular structure Open
Long-term cumulative hsCRP exposure was associated with wider venules in young and mid-adulthood, whereas the associations with venular tortuosity were inconsistent. Wider retinal venules might act as a marker for cumulative inflammatory b…
View article: The effect of polychlorinated biphenyls on type 2 diabetes risk is mediated via DNA methylation
The effect of polychlorinated biphenyls on type 2 diabetes risk is mediated via DNA methylation Open
Polychlorinated biphenyls (PCBs) have been identified as diabetogens and potential epigenetic regulators. Epigenetic variation is implicated in the pathogenesis of type 2 diabetes (T2D) and is therefore a potential mechanism linking PCB ex…
Cardiovascular outcomes of patients with type 2 diabetes after myocardial infarction and the impact of diabetes duration: a nationwide registry study Open
Patients with type 2 diabetes have impaired long-term cardiovascular outcomes after an MI, underlining the importance of effective secondary prevention. Patients with a longer diabetes duration are at a particularly high risk.
View article: Prevalence of carotid atherosclerosis in 3-92-year-old Finns. The 3-generational cardiovascular risk in young Finns study
Prevalence of carotid atherosclerosis in 3-92-year-old Finns. The 3-generational cardiovascular risk in young Finns study Open
Carotid artery plaques are very prevalent finding among Finnish adults but not observed in children of the general population. High LDL-cholesterol concentration and hypertension are strongly associated with plaques, especially among young…
View article: Life-course neighbourhood socioeconomic disadvantage and atherosclerotic carotid artery plaques. The Cardiovascular Risk in Young Finns Study
Life-course neighbourhood socioeconomic disadvantage and atherosclerotic carotid artery plaques. The Cardiovascular Risk in Young Finns Study Open
Background Neighbourhood socioeconomic disadvantage is a known determinant of cardiovascular disease (CVD) risk. However, its impact on subclinical atherosclerosis across the life course remains inadequately understood. This study examined…
View article: The associations between intergenerational mobility of income and cognitive function in midlife–The Young Finns Study
The associations between intergenerational mobility of income and cognitive function in midlife–The Young Finns Study Open
Individuals with stable high income may have better midlife cognitive function. This finding highlights the role of life-course SES for disparities in adulthood cognitive function. Understanding the role of early-life determinants of midli…
View article: Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study
Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study Open
Research Council of Finland, Social Insurance Institution of Finland, Competitive State Research Financing of the Expert Responsibility area of the Kuopio, Tampere and Turku University Hospitals, Juho Vainio Foundation, Paavo Nurmi Foundat…
Cardiometabolic determinants of aortic and carotid intima-media thickness in adolescence Open
In adolescence, several cardiometabolic risk factors associate with aortic IMT while these links are less evident for carotid IMT. Aortic IMT may serve as a more sensitive marker than carotid IMT of early vascular remodeling.
View article: Blood pressure in childhood, young- and mid-adulthood: association with carotid plaque severity
Blood pressure in childhood, young- and mid-adulthood: association with carotid plaque severity Open
Background and Aims Blood pressure (BP) is a key modifiable risk factor for atherosclerosis. How BP across different life stages associates with carotid plaque in mid-adulthood remains unclear, which is the aim of this study. Methods The s…
View article: Association of neighbourhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study
Association of neighbourhood and individual-level socioeconomic disadvantage in childhood and adulthood with cognitive function in mid-adulthood: Cardiovascular Risk in Young Finns Study Open
Socioeconomic disadvantage at individual level is associated with poor cognitive outcomes but the link of neighbourhood disadvantage with cognitive function is unclear. We used data from Young Finns Study, a population-based cohort, to exa…
View article: The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium
The association of childhood HDL cholesterol with atherosclerotic cardiovascular disease events in adults: findings from the International Childhood Cardiovascular Cohort Consortium Open
Aims The role of adult HDL-C in atherosclerotic cardiovascular disease (ASCVD) faces challenges from Mendelian randomizations and drug trials. However, the association between childhood HDL-C and its changes and adult ASCVD remains undefin…
View article: Maternal Smoking Intensity During Pregnancy and Early Adolescent Cardiovascular Health
Maternal Smoking Intensity During Pregnancy and Early Adolescent Cardiovascular Health Open
Background The adverse cardiovascular effects of smoking are well established. We aimed to investigate the less well‐understood effects of pregnancy smoke exposure on offspring cardiovascular health in early adolescence. Methods and Result…
A multilayer network analysis of cardiovascular–depression comorbidity reveals symptom-specific molecular biomarkers Open
Background Cardiovascular diseases (CVD) and depression frequently co-occur, yet the biological mechanisms underpinning this comorbidity remain poorly understood. This may reflect complex, non-linear associations across multiple biological…
Associations of Cumulative Adulthood, Childhood and Lifelong Insulin With Adulthood Retinal Microvasculature Open
Context Exogenous insulin is reported to have both vasodilatory and vasoconstrictive effects on microvasculature. Little is known about the associations of long-term endogenous insulin exposure with microvasculature. Objective To test the …
Cohort Profile Update: Expanding the Cardiovascular Risk in Young Finns Study into a multigenerational cohort Open
Cardiovascular Risk in Young Finns Study (YFS) is a prospective cohort of 3596 males and females (baseline age 3-18 years) that was established in 1980 to study cardiovascular risk factors in children and adolescents. The YFS has been inst…
Efficient Search Algorithms for Identifying Synergistic Associations in High-Dimensional Datasets Open
In recent years, there has been a notably increased interest in the study of multivariate interactions and emergent higher-order dependencies. This is particularly evident in the context of identifying synergistic sets, which are defined a…
View article: Tracking of Vascular Measures From Infancy to Early Childhood: A Cohort Study
Tracking of Vascular Measures From Infancy to Early Childhood: A Cohort Study Open
Background Atherosclerosis develops across the life course, and variation in aortic intima‐media thickness (IMT) is evident from infancy onward, although most early‐life data are cross‐sectional. We investigated whether abdominal aortic IM…
View article: Tracking and Transition Probability of Blood Pressure From Childhood to Midadulthood
Tracking and Transition Probability of Blood Pressure From Childhood to Midadulthood Open
Importance Despite its relevance for pediatric blood pressure (BP) screening, the long-term predictive utility and natural progression of pediatric BP classification remain understudied. Objective To evaluate BP tracking from childhood to …
Short- and long-term mortality in patients with type 2 diabetes after myocardial infarction– a nationwide registry study Open
Type 2 diabetes had a negative impact on both short- and long-term outcome after MI, but effect sizes were relatively small. Patients with longer duration of diabetes or need for insulin therapy are still at particular risk.
View article: Predictors in Youth of Adult Cardiovascular Events
Predictors in Youth of Adult Cardiovascular Events Open
BACKGROUND AND OBJECTIVES Childhood risk factors are associated with cardiovascular events in adulthood. We compared the utility of a risk model based solely on nonlaboratory risk factors in adolescence versus a model that additionally inc…
Life-period associations of body mass index with adult carotid intima-media thickness: The Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study Open
Although our data suggest sensitive periods in the life-course where prevention and intervention aimed at reducing BMI might provide most benefit in limiting the effects of BMI on cIMT, maintaining lower BMI across the life-course appears …
View article: Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis Open
Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time …
Performance of D-dimer, cardiac troponin T, C-reactive protein, and NT-proBNP in prediction of long-term mortality in patients with suspected pulmonary embolism Open
Aims Pulmonary embolism (PE) is a common and potentially life-threatening condition requiring emergent diagnostic work-up. Despite wide use of biomarkers, little is known how they predict long-term prognosis of patients evaluated for suspe…