Patrick May
YOU?
Author Swipe
View article: Resistant starch improves Parkinson’s disease symptoms through restructuring of the gut microbiome and modulating inflammation
Resistant starch improves Parkinson’s disease symptoms through restructuring of the gut microbiome and modulating inflammation Open
Alterations in the gut microbiome and a "leaky" gut are associated with Parkinson's disease (PD), which implies the prospect of rebalancing via dietary intervention. Here, we investigate the impact of a diet rich in resistant starch on the…
View article: Modifiable lifestyle factors and genetic risk of obesity in Indians
Modifiable lifestyle factors and genetic risk of obesity in Indians Open
This study investigates whether sustained adherence to a healthy lifestyle is associated with lower obesity risk among individuals of Indian ancestry who have a high polygenic risk score (PRS) for body mass index (BMI). For the purposes of…
View article: Genetic risk factor identification for common epilepsies guided by integrative omics data analysis
Genetic risk factor identification for common epilepsies guided by integrative omics data analysis Open
Objective Genetic generalized epilepsies (GGEs) comprise the most common genetically determined epilepsy syndromes, following a complex mode of inheritance. Although many important common and rare genetic factors causing or contributing to…
View article: Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson’s disease
Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson’s disease Open
Background Parkinson’s disease (PD) is associated with gut microbiome shifts. These shifts are mainly described at taxonomic level, but the functional consequences remain unclear. To obtain insight into the functional disruptions of the gu…
View article: Shoulder dislocations in professional male football (soccer) do not negatively affect long‐term quantitative and qualitative performance parameters: A retrospective analysis of 30 in‐match injuries of the German Bundesliga
Shoulder dislocations in professional male football (soccer) do not negatively affect long‐term quantitative and qualitative performance parameters: A retrospective analysis of 30 in‐match injuries of the German Bundesliga Open
Purpose Shoulder dislocations in professional football are increasing and regularly associated with substantial layoff times. However, research on players' postinjury performance remains limited. Therefore, the purpose of this study was to…
View article: Predicting Drug Response with Multi-Task Gradient-Boosted Trees in Epilepsy
Predicting Drug Response with Multi-Task Gradient-Boosted Trees in Epilepsy Open
Motivation Despite the availability of numerous anti-seizure medications (ASMs), drug resistance remains a major issue for people with epilepsy. The probability of achieving seizure freedom diminishes with each unsuccessful drug trial, and…
View article: Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson’s disease
Multi-cohort machine learning identifies predictors of cognitive impairment in Parkinson’s disease Open
Cognitive impairment is a frequent complication of Parkinson’s disease (PD), affecting up to half of newly diagnosed patients. To improve early detection and risk assessment, we developed machine learning models using clinical data from th…
View article: Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson’s disease
Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson’s disease Open
Gut microbiome alterations are linked to various diseases, including neurodegeneration, but their ecological and functional impacts remain unclear. Using integrated multi-omics (metagenomics and metatranscriptomics), we analyse microbiome …
View article: Use of cannabidiol for off-label treatment of patients with refractory focal, genetic generalised and other epilepsies
Use of cannabidiol for off-label treatment of patients with refractory focal, genetic generalised and other epilepsies Open
Background In randomized controlled trials, add-on cannabidiol (CBD) has been shown to reduce seizure frequency in patients with Lennox-Gastaut syndrome, Dravet syndrome and Tuberous sclerosis complex. Real-world studies provide insights i…
View article: Efficacy and tolerability of fenfluramine with concomitant potassium bromide in patients with Dravet syndrome
Efficacy and tolerability of fenfluramine with concomitant potassium bromide in patients with Dravet syndrome Open
Objective To assess the efficacy and tolerability of fenfluramine (FFA) with concomitant potassium bromide (BR) in patients with Dravet syndrome (DS). Methods This multicenter retrospective study, conducted within the German compassionate …
View article: Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes
Conserved missense variant pathogenicity and correlated phenotypes across paralogous genes Open
Background The majority of missense variants in clinical genetic tests are classified as variants of uncertain significance. Prior research shows that the deleterious effects and the subsequent molecular consequences of variants are often …
View article: Associations of age at menopause, bilateral oophorectomy, hysterectomy and hormone replacement therapy with glycaemia and risk of dementia: a study based on the population-based UK Biobank cohort
Associations of age at menopause, bilateral oophorectomy, hysterectomy and hormone replacement therapy with glycaemia and risk of dementia: a study based on the population-based UK Biobank cohort Open
Introduction Menopausal factors, including age at menopause, bilateral oophorectomy, hysterectomy and hormone replacement therapy (HRT), have been associated with dementia risk, which might be due to increased glucose levels after menopaus…
View article: Penetrance of Parkinson's disease in GBA1 carriers depends on the variant severity and polygenic background
Penetrance of Parkinson's disease in GBA1 carriers depends on the variant severity and polygenic background Open
Heterozygous GBA1 variants increase Parkinson’s disease (PD) risk with variable penetrance. We investigated the interaction between genome-wide polygenic risk scores (PRS) and severity of pathogenic GBA1 variants (GBA1PVs) to assess their …
View article: An Approach to Integrate Metagenomics, Metatranscriptomics and Metaproteomics Data in Public Data Resources
An Approach to Integrate Metagenomics, Metatranscriptomics and Metaproteomics Data in Public Data Resources Open
The availability of public metaproteomics, metagenomics and metatranscriptomics data in public resources such as MGnify (for metagenomics/metatranscriptomics) and the PRIDE database (for metaproteomics), continues to increase. When these o…
View article: Modifiable lifestyle factors and genetic risk of obesity in Indians
Modifiable lifestyle factors and genetic risk of obesity in Indians Open
This study investigates the potential for individuals of Indian ancestry with an increased polygenic risk score (PRS) for body mass index (BMI) to attenuate their risk of obesity through sustained adherence to a health-promoting lifestyle.…
View article: Genome-wide association meta-analyses of drug-resistant epilepsy
Genome-wide association meta-analyses of drug-resistant epilepsy Open
This work is part of the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 279062 (EpiPGX) and the Centers for Common Disease Genomics (CCDG) program, funded by the National Human Genome Research Institu…
View article: SyMetrics: An Integrated Machine Learning Model for Evaluating the Pathogenicity of Synonymous Variants in the Human Genome
SyMetrics: An Integrated Machine Learning Model for Evaluating the Pathogenicity of Synonymous Variants in the Human Genome Open
Synonymous single nucleotide variants (sSNVs), traditionally seen as neutral, are now recognized for their biological impact. To assess their relevance, we developed SyMetrics, a framework that integrates predictors of splicing, RNA stabil…
View article: Real-world experience of cannabidiol in conjunction with clobazam for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome: Results from a retrospective multicentre chart review in Germany
Real-world experience of cannabidiol in conjunction with clobazam for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome: Results from a retrospective multicentre chart review in Germany Open
In this chart review of patients with severe treatment refractory LGS or DS receiving adjunctive CBD and CLB concomitantly, a reduction in seizure frequency and sustained treatment retention was observed for up to 12 months across age grou…
View article: An improved polygenic score for Parkinson’s disease partly explains variable penetrance of genetic Parkinson’s disease
An improved polygenic score for Parkinson’s disease partly explains variable penetrance of genetic Parkinson’s disease Open
While genetic causes are identified in up to 15% of all Parkinson’s disease (PD) patients, the remaining idiopathic PD (iPD) patients are attributed to polygenic risk, environmental and lifestyle factors, and interactions thereof. We appli…
View article: Therapy response prediction of focal cortex stimulation based on clinical parameters: a multicentre, non-interventional study protocol
Therapy response prediction of focal cortex stimulation based on clinical parameters: a multicentre, non-interventional study protocol Open
Introduction A novel focal cortex stimulation (FCS) device has recently received approval in Europe for patients with focal drug-resistant epilepsy (DRE). After 6 months of stimulation, 17 of 32 patients achieved ≥50% reduction in seizure …
View article: Penetrance of Parkinson’s disease in<i>GBA1</i>carriers is depending on the variant severity and polygenic background
Penetrance of Parkinson’s disease in<i>GBA1</i>carriers is depending on the variant severity and polygenic background Open
Background Heterozygous variants in the GBA1 gene cause Parkinson’s disease (PD) with variable penetrance and have been classified into severe, mild, and PD-specific risk variants based on their association with Gaucher’s disease (GD; mild…
View article: An approach to integrate metagenomics, metatranscriptomics and metaproteomics data in public resources
An approach to integrate metagenomics, metatranscriptomics and metaproteomics data in public resources Open
The availability of public metaproteomics, metagenomics and metatranscriptomics data in public resources such as MGnify (for metagenomics/metatranscriptomics) and the PRIDE database (for metaproteomics), continues to increase. When these o…
View article: Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson′s disease
Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson′s disease Open
Alterations of gut microbiome structure have been observed in a panoply of human diseases including neurodegeneration. However, the ecological and functional deficits of microbiome dysbiosis have yet to be understood. Here, using integrate…
View article: Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson’s disease
Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson’s disease Open
Summary Parkinson’s disease (PD) is associated with gut microbiome shifts, but the functional consequences remain unclear. Here, we use an integrated multi-omics approach to compare the gut microbiomes of individuals with PD and prodromal …