John McLaughlin
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View article: Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants
Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants Open
Background Chronic pancreatitis (CP) is a multifaceted and irreversible inflammatory condition that impacts both endocrine and exocrine pancreatic functions. Whilst there is evidence of a general intestinal microbial dysbiosis, differences…
View article: White Paper on Nutrition Sensing and Ageing
White Paper on Nutrition Sensing and Ageing Open
Ageing, which is defined as the progressive deterioration of physiological functions, is an inevitable part of the lifecycle. Nevertheless, its progress is believed to be influenced by modifiable factors, one of the most important being di…
View article: Systematic mapping of registered interventional studies addressing the top 10 research priorities in Barrett’s oesophagus and gastro-oesophageal reflux disease
Systematic mapping of registered interventional studies addressing the top 10 research priorities in Barrett’s oesophagus and gastro-oesophageal reflux disease Open
Objectives The top 10 research priorities (RPs) for Barrett’s oesophagus (BO) were published in 2017. This study aimed to identify the current research landscape on addressing RPs. Design Systematic mapping review. Data sources ClinicalTri…
View article: ABS0165 PROVISIONAL EXPERT RECOMMENDATIONS FOR THE MANAGEMENT OF FECAL INCONTINENCE IN SYSTEMIC SCLEROSIS: A REPORT FROM WORLD SCLERODERMA FOUNDATION (WSF) GASTROINTESTINAL “AD HOC COMMITTEE”
ABS0165 PROVISIONAL EXPERT RECOMMENDATIONS FOR THE MANAGEMENT OF FECAL INCONTINENCE IN SYSTEMIC SCLEROSIS: A REPORT FROM WORLD SCLERODERMA FOUNDATION (WSF) GASTROINTESTINAL “AD HOC COMMITTEE” Open
International audience
View article: Lifestyle restrictions are associated with impaired quality of life but not reduction in relapse in ulcerative colitis
Lifestyle restrictions are associated with impaired quality of life but not reduction in relapse in ulcerative colitis Open
Lifestyle restrictions were not associated with relapse reduction in patients with UC; however, they were associated with impaired QOL. Clinicians should engage in evidence-based discussions with patients with UC in remission regarding lif…
View article: Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants
Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants Open
Background Chronic pancreatitis (CP) is a multifaceted and irreversible inflammatory condition that impacts both endocrine and exocrine pancreatic functions. Whilst there is evidence of a general intestinal microbial dysbiosis, differences…
View article: Co-Administration of BNT162b2 COVID-19 and Influenza Vaccines in Adults: A Global Systematic Review
Co-Administration of BNT162b2 COVID-19 and Influenza Vaccines in Adults: A Global Systematic Review Open
Background/Objectives: Co-administration of BNT162b2 with licensed seasonal influenza vaccines (SIVs) is recommended by health authorities. We provide a comprehensive summary of the data supporting this practice in adults. Methods: This sy…
View article: Colonic inflammation modulates the intestinal circadian landscape
Colonic inflammation modulates the intestinal circadian landscape Open
Summary Inflammatory bowel disease (IBD) is a chronic inflammatory condition that carries significant morbidity. The circadian (24h) clock regulates many aspects of immunity and circadian disruption is implicated in inflammatory disease. W…
View article: Provocative tests of anal sphincter function correlate with symptoms and subtypes of faecal incontinence
Provocative tests of anal sphincter function correlate with symptoms and subtypes of faecal incontinence Open
Objectives High-resolution anorectal manometry (HRAM) is the established investigation in faecal incontinence (FI). However, provocative tests (functional lumen imaging probe (FLIP) and anal acoustic reflectometry (AAR)) have been proposed…
View article: Early effectiveness of the BNT162b2 KP.2 vaccine against COVID-19 in the US Veterans Affairs Healthcare System
Early effectiveness of the BNT162b2 KP.2 vaccine against COVID-19 in the US Veterans Affairs Healthcare System Open
We conducted a test-negative case-control study within the US Veterans Affairs Healthcare System to estimate early vaccine effectiveness (VE) of the BNT162b2 KP.2 vaccine (Pfizer 2024-2025 formulation) against COVID-19 outcomes. Among 44,5…
View article: Optimising fatigue, abdominal pain and faecal incontinence in people with inflammatory bowel disease (IBD-BOOST Optimise): feasibility study of a checklist and algorithm for initial nurse-led management
Optimising fatigue, abdominal pain and faecal incontinence in people with inflammatory bowel disease (IBD-BOOST Optimise): feasibility study of a checklist and algorithm for initial nurse-led management Open
Objective Many people with inflammatory bowel disease (IBD) experience fatigue, pain and faecal incontinence that some feel are inadequately addressed. It is unknown how many have potentially reversible medical issues underlying these symp…
View article: An evaluation of autonomic and gastrointestinal symptoms, and gastric emptying, in patients with systemic sclerosis
An evaluation of autonomic and gastrointestinal symptoms, and gastric emptying, in patients with systemic sclerosis Open
Objective: Assessment of gastrointestinal and autonomic symptoms in patients with systemic sclerosis, and possible associations with gastric emptying rate. Methods: Participant and patient disease-related characteristics were collected. Ga…
View article: Healthy Eating and Active Lifestyle after Bowel Cancer (HEAL ABC)—feasibility randomised controlled trial
Healthy Eating and Active Lifestyle after Bowel Cancer (HEAL ABC)—feasibility randomised controlled trial Open
Background Evidence from cohort studies indicates that a healthy lifestyle can improve cancer survival but evidence from randomised controlled trials (RCT) is lacking. Thus, this study tested the feasibility of conducting a lifestyle inter…
View article: A comparison of function lumen imaging probe measurements of anal sphincter function in fecal incontinence
A comparison of function lumen imaging probe measurements of anal sphincter function in fecal incontinence Open
Background The functional lumen imaging probe (FLIP) is a test of anal sphincter distensibility under evaluation by specialist centers. Two measurement protocols termed “stepwise” and “ramp” are used, risking a lack of standardization. Thi…
View article: O100: A novel bedside assessment of skeletal muscle wasting predicts treatment-related toxicity prior to major surgery – The Muscle Ultrasound in Esophagogastric Cancer (MUSEC) study
O100: A novel bedside assessment of skeletal muscle wasting predicts treatment-related toxicity prior to major surgery – The Muscle Ultrasound in Esophagogastric Cancer (MUSEC) study Open
Sarcopenia is an important prognosticator during treatment for Oesophagogastric (OG) cancer. Despite this, sarcopenia is not routinely measured in clinical practice due to resource availability. Ultrasound is emerging as a potential tool t…
View article: O101: Current guidelines on physical activity do not prevent skeletal muscle loss and physical decline prior to Oesophagogastric cancer surgery: a new benchmark for prehabilitation?
O101: Current guidelines on physical activity do not prevent skeletal muscle loss and physical decline prior to Oesophagogastric cancer surgery: a new benchmark for prehabilitation? Open
Prehabilitation is being widely adopted to optimise physical health prior to surgery. However, there remains a lack of consensus regarding exercise type and intensity with current guidance extrapolated from generic, non-cancer populations.…
View article: Percutaneous tibial nerve stimulation versus sacral nerve stimulation for the treatment of faecal incontinence
Percutaneous tibial nerve stimulation versus sacral nerve stimulation for the treatment of faecal incontinence Open
Introduction Faecal incontinence (FI) is a common condition with a significant impact on quality of life (QoL). Neuromodulation treatments delivered by members of the multidisciplinary team including sacral nerve stimulation (SNS) and perc…
View article: Consumption of the Non-Nutritive Sweetener Stevia for 12 Weeks Does Not Alter the Composition of the Human Gut Microbiota
Consumption of the Non-Nutritive Sweetener Stevia for 12 Weeks Does Not Alter the Composition of the Human Gut Microbiota Open
The use of non-nutritive sweeteners (NNSs) as an alternative to caloric sugars has increased in recent years. Stevia is an NNS that has demonstrated beneficial effects on appetite and energy intake. However, the impact on the gut microbiot…
View article: Healthy Eating and Active Lifestyle after Bowel Cancer (HEAL ABC) – Feasibility Randomised Controlled Trial
Healthy Eating and Active Lifestyle after Bowel Cancer (HEAL ABC) – Feasibility Randomised Controlled Trial Open
Background: Evidence from cohort studies indicates that a healthy lifestyle can improve cancer survival but evidence from randomised controlled trials (RCT) is lacking. Thus, this study tested the feasibility of conducting a lifestyle inte…
View article: Biologic Therapy for Inflammatory Bowel Disease: Real-World Comparative Effectiveness and Impact of Drug Sequencing in 13 222 Patients within the UK IBD BioResource
Biologic Therapy for Inflammatory Bowel Disease: Real-World Comparative Effectiveness and Impact of Drug Sequencing in 13 222 Patients within the UK IBD BioResource Open
Background and Aims This study compares the effectiveness of different biologic therapies and sequences in patients with inflammatory bowel disease [IBD] using real-world data from a large cohort with long exposure. Methods Demographic, di…
View article: OGC P12 The Current Landscape of Nutritional Care in Oesophahgogastric Cancer: Insights from The National Oesophagogastric Nutrition Audit (NONA)
OGC P12 The Current Landscape of Nutritional Care in Oesophahgogastric Cancer: Insights from The National Oesophagogastric Nutrition Audit (NONA) Open
Background Specialist nutritional support is important during treatment for oesophagogastric (OG) cancer yet current practice remains unstandardised across the UK. The National Oesophagogastric Nutrition Audit (NONA) aimed to describe the …
View article: Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial
Ondansetron for irritable bowel syndrome with diarrhoea: randomised controlled trial Open
Background Irritable bowel syndrome with diarrhoea is characterised by frequent, loose or watery stools with associated urgency, resulting in marked reduction of quality of life. Ondansetron, a 5-hydroxytryptamine-3 receptor antagonist, ha…
View article: Habit training versus habit training with direct visual biofeedback in adults with chronic constipation: A randomized controlled trial
Habit training versus habit training with direct visual biofeedback in adults with chronic constipation: A randomized controlled trial Open
Aim The aim was to determine whether specialist‐led habit training using Habit Training with Biofeedback (HTBF) is more effective than specialist‐led habit training alone (HT) for chronic constipation and whether outcomes of interventions …
View article: Dedicated service for Barrett’s oesophagus surveillance endoscopy yields higher dysplasia detection and guideline adherence in a non-tertiary setting in the UK: a 5-year comparative cohort study
Dedicated service for Barrett’s oesophagus surveillance endoscopy yields higher dysplasia detection and guideline adherence in a non-tertiary setting in the UK: a 5-year comparative cohort study Open
Objective Barrett’s oesophagus (BO) endoscopic surveillance is performed to varying quality, dedicated services may offer improved outcomes. This study compares a dedicated BO service to standard care, specifically dysplasia detection rate…