Toshio Morikawa
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View article: Inhibitory Effect of <i>Ilex Latifolia</i> Leaf Extract on Postprandial Increase in Blood Glucose Level
Inhibitory Effect of <i>Ilex Latifolia</i> Leaf Extract on Postprandial Increase in Blood Glucose Level Open
Aim Kuding tea brewed from Ilex latifolia (IL) leaves has been traditionally consumed and regarded as “beauty‐slimming tea” and “longevity tea” in China, albeit supporting theoretical evidence is lacking. This study aims to determine wheth…
View article: Lentinula edodes mycelia extract abrogates chemotherapy-evoked cold and mechanical allodynia in mice
Lentinula edodes mycelia extract abrogates chemotherapy-evoked cold and mechanical allodynia in mice Open
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a detrimental outcome of various antineoplastic drugs, such as paclitaxel (PTX), vincristine (VCR), oxaliplatin (L-OHP), and bortezomib (BOR). CIPN results in pain and disabil…
View article: Synthesis and biological evaluation of γ-alkylidenebutenolides isolated from <i>Melodorum fruticosum</i> : the role of the propylidene-type side chain structure on anti-melanogenic activity
Synthesis and biological evaluation of γ-alkylidenebutenolides isolated from <i>Melodorum fruticosum</i> : the role of the propylidene-type side chain structure on anti-melanogenic activity Open
The first structure–activity relationship study on γ-alkylidenebutenolides [(4 Z )- and (4 E )-6,7-dihydroxyhepta-2,4-dien-4-olide 6-monobenzoate] (3 and 4) and 7-monobenzoate (1 and 2) was carried out using the related analogous (7–21).
View article: Epidermal and Blood Vessel Barrier Functions of Glucosylceramides and Digalactosyldiacylglycerols Isolated from Yellow Strawberry Guava
Epidermal and Blood Vessel Barrier Functions of Glucosylceramides and Digalactosyldiacylglycerols Isolated from Yellow Strawberry Guava Open
Strawberry guava is the fruit of Psidium littorale, which grows in tropical regions. Few studies have examined the hydrophobic compounds and biological activities of this fruit. Therefore, we purified lipophilic compounds of strawberry gua…
View article: Role of the thiosugar ring in the inhibitory activity of salacinol, a potent natural α-glucosidase inhibitor
Role of the thiosugar ring in the inhibitory activity of salacinol, a potent natural α-glucosidase inhibitor Open
In contrast to previous SAR studies of aza-compounds (23 vs. 24 and 25), the present study using analogues (26a–26c, 27c, and 28a–28c) of salacinol (1) revealed an essential role of the thiosugar ring in effectively inhibiting α-glucosidas…
View article: Pharmaceutical Food Science: Search for Bio-Functional Molecules Obtained from Natural Resources to Prevent and Ameliorate Lifestyle Diseases
Pharmaceutical Food Science: Search for Bio-Functional Molecules Obtained from Natural Resources to Prevent and Ameliorate Lifestyle Diseases Open
In this review, our resent pharmaceutical food science research for bio-functional molecules obtained from natural resources that contribute to i) suppression of postprandial blood glucose elevation and/or improvement of glucose tolerance …
View article: Publisher Correction: New biofunctional effects of oleanane-type triterpene saponins
Publisher Correction: New biofunctional effects of oleanane-type triterpene saponins Open
4 1), which shows the chemical structure of olean-12-en-28-oic acid 3-O-monodesmoside, are incorrect.The incorrect "oleanolic acid 3-O-glucuronide (18)" has now been replaced with the correct "oleanolic acid 3-O-glucuronide ( 16)", and the…
View article: New biofunctional effects of oleanane-type triterpene saponins
New biofunctional effects of oleanane-type triterpene saponins Open
In the current review, we describe the novel biofunctional effects of oleanane-type triterpene saponins, including elatosides, momordins, senegasaponins, camelliasaponins, and escins, obtained from Aralia elata (bark, root cortex, young sh…
View article: Hepatoprotective Principles from the Rhizomes of <i>Picrorhiza kurroa</i>
Hepatoprotective Principles from the Rhizomes of <i>Picrorhiza kurroa</i> Open
A methanol extract of rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae) showed hepatoprotective effects against D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. We had previously isolated 46 comp…
View article: Ameliorative effect of bofutsushosan (fangfengtongshengsan) extract on the progression of aging-induced obesity
Ameliorative effect of bofutsushosan (fangfengtongshengsan) extract on the progression of aging-induced obesity Open
This study aimed to compare fat accumulation in young and aged mice raised on a high-fat diet and to characterize the obesity-reducing effects of a traditional Japanese Kampo medicine, bofutsushosan (BTS; fangfengtongshengsan in Chinese). …
View article: Structures of Mammeasins P and Q, Coumarin-Related Polysubstituted Benzofurans, from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Anti-Proliferative Activity of Coumarin Constituents against Human Prostate Carcinoma Cell Line LNCaP
Structures of Mammeasins P and Q, Coumarin-Related Polysubstituted Benzofurans, from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Anti-Proliferative Activity of Coumarin Constituents against Human Prostate Carcinoma Cell Line LNCaP Open
A methanol extract of the flowers of Mammea siamensis (Miq.) T. Anders. (Calophyllaceae) showed anti-proliferative activity against human prostate carcinoma LNCaP cells (IC50 = 2.0 µg/mL). Two new coumarin-related polysubstituted benzofura…
View article: Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides
Comparative Study on Epidermal Moisturizing Effects and Hydration Mechanisms of Rice-Derived Glucosylceramides and Ceramides Open
Ceramide (Cer) plays an important role in skin barrier functions in the stratum corneum (SC). The ingestion of food-derived glucosylceramides (GlcCer) attenuates transepidermal water loss (TEWL). However, the moisturizing effects of single…
View article: A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells
A Gedunin-Type Limonoid, 7-Deacetoxy-7-Oxogedunin, from Andiroba (Carapa guianensis Aublet) Reduced Intracellular Triglyceride Content and Enhanced Autophagy in HepG2 Cells Open
The seed oil of Carapa guianensis Aublet (Andiroba) has been used in folk medicine for its insect-repelling, anti-inflammatory, and anti-malarial activities. This study aimed to examine the triglyceride (TG) reducing effects of C. guianens…
View article: Phytochemicals with Chemopreventive Activity Obtained from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Isolation and Structure Determination of New Prenylcoumarins with Inhibitory Activity against Aromatase
Phytochemicals with Chemopreventive Activity Obtained from the Thai Medicinal Plant Mammea siamensis (Miq.) T. Anders.: Isolation and Structure Determination of New Prenylcoumarins with Inhibitory Activity against Aromatase Open
With the aim of searching for phytochemicals with aromatase inhibitory activity, five new prenylcoumarins, mammeasins K (1), L (2), M (3), N (4), and O (5), were isolated from the methanolic extract of Mammea siamensis (Miq.) T. Anders. fl…
View article: Bio-Functional Natural Products in Edible Resources for Human Health and Beauty
Bio-Functional Natural Products in Edible Resources for Human Health and Beauty Open
Natural products remain important repositories of promising therapeutic candidates due to their rich chemical and biological diversity. The Special Issue on "Bio-functional Natural Products in Edible Resources for Human Health and Beauty" …
View article: Bio-Functional Natural Products in Edible Resources for Human Health and Beauty
Bio-Functional Natural Products in Edible Resources for Human Health and Beauty Open
Natural products remain important repositories of promising therapeutic candidates due to their rich chemical and biological diversity [...]
View article: Antiallergic Properties of Biflavonoids Isolated from the Flowers of Mesua ferrea Linn.
Antiallergic Properties of Biflavonoids Isolated from the Flowers of Mesua ferrea Linn. Open
The methanolic extract from the flowers of Mesua ferrea Linn. (Calophyllaceae) showed significant hyaluronidase inhibitory activity. Following a bioassay-guided separation of the extract, two biflavonoids, viz., mesuaferrone-A (1) and mesu…
View article: Analysis of Active Compounds Using Target Protein Cofilin―Cucurbitacins in Cytotoxic Plant Bryonia cretica
Analysis of Active Compounds Using Target Protein Cofilin―Cucurbitacins in Cytotoxic Plant Bryonia cretica Open
We examined a two-step target protein binding strategy that uses cofilin as the target protein to analyze the active constituents in Bryonia cretica. In the first step, we prepared the target protein, and used it to analyze the compounds b…
View article: Lycoperoside H, a Tomato Seed Saponin, Improves Epidermal Dehydration by Increasing Ceramide in the Stratum Corneum and Steroidal Anti-Inflammatory Effect
Lycoperoside H, a Tomato Seed Saponin, Improves Epidermal Dehydration by Increasing Ceramide in the Stratum Corneum and Steroidal Anti-Inflammatory Effect Open
Tomatoes are widely consumed, however, studies on tomato seeds are limited. In this study, we isolated 11 compounds including saponins and flavonol glycosides from tomato seeds and evaluated their effects on epidermal hydration. Among the …
View article: Oryza Ceramide®, a rice-derived extract consisting of glucosylceramides and β-sitosterol glucoside, improves facial skin dehydration in Japanese subjects
Oryza Ceramide®, a rice-derived extract consisting of glucosylceramides and β-sitosterol glucoside, improves facial skin dehydration in Japanese subjects Open
Background and objective: The ingestion of plant-derived glucosylceramides (GlcCer) has been reported to contribute to skin barrier function and hydration of the epidermis. b-sitosterol glucoside (BSG) colocalized with GlcCer in the rice h…
View article: Indole Glycosides from <i>Calanthe discolor</i> with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells
Indole Glycosides from <i>Calanthe discolor</i> with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells Open
A methanol extract from the underground part of Calanthe discolor Lindl. (Orchidaceae) demonstrated significant proliferative activity on human hair follicle dermal papilla cells (HFDPC, % of control: 120.8 ± 0.2%) at 100 µg/mL against HFD…
View article: A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia
A review of antidiabetic active thiosugar sulfoniums, salacinol and neokotalanol, from plants of the genus Salacia Open
During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol ( 1 ) and neokotalanol ( 4 ), and related thiosugar …
View article: Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family
Ligand compatibility of salacinol-type α-glucosidase inhibitors toward the GH31 family Open
Salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3′-O-benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels.