Atsushi Nagai
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View article: A Hot-Spring Water Improves Inflammatory Conditions in an Injury-Induced Atopic Dermatitis Mouse Model by Regulating Skin Barrier Function
A Hot-Spring Water Improves Inflammatory Conditions in an Injury-Induced Atopic Dermatitis Mouse Model by Regulating Skin Barrier Function Open
Background: Atopic dermatitis (AD) is a common inflammatory skin condition in which skin barrier function plays a crucial role. Hot spring water is known for its beneficial effects on skin health. This study investigates the impact of a ho…
View article: Bilateral Middle Cerebellar Peduncle Lesions in Wernicke's Encephalopathy
Bilateral Middle Cerebellar Peduncle Lesions in Wernicke's Encephalopathy Open
Bilateral MCP lesions have a diverse etiology, ranging from treatable conditions to diseases with poor prognosis. Although uncommon, Wernicke's encephalopathy (WE) should be considered in the differential diagnosis of MCP lesions, particul…
View article: Impact of the Apolipoprotein E ε4 Allele on Cognition and Omega-3 Fatty Acid Levels in the Plasma Membrane of Red Blood Cells in Healthy Elderly Japanese Population
Impact of the Apolipoprotein E ε4 Allele on Cognition and Omega-3 Fatty Acid Levels in the Plasma Membrane of Red Blood Cells in Healthy Elderly Japanese Population Open
Introduction: The ε4 allele of the apolipoprotein E (APOE4) gene is a well-known risk factor for the onset and development of late-onset Alzheimer’s disease (AD). Lipid metabolism also plays a key role in AD. However, data on the associati…
View article: A Hot-Spring Water Improves Inflammatory Conditions in an Injury-Induced Atopic Dermatitis Mouse Model by Regulating Skin Barrier Function
A Hot-Spring Water Improves Inflammatory Conditions in an Injury-Induced Atopic Dermatitis Mouse Model by Regulating Skin Barrier Function Open
Atopic dermatitis is a common inflammatory skin condition in which skin barrier function plays a crucial role. Hot spring water is known for its beneficial effects on skin health. This study investigates the impact of a hot spring water on…
View article: A High-Fat Diet Increases Kidney Fibrosis Through Regulating TGF-β and PDGF-β Signaling Pathways in Normotensive and Hypertensive Rat Models
A High-Fat Diet Increases Kidney Fibrosis Through Regulating TGF-β and PDGF-β Signaling Pathways in Normotensive and Hypertensive Rat Models Open
Hypertension and obesity are well-established risk factors for chronic kidney disease (CKD). This study investigates the interaction between these two factors in CKD using animal models. Twelve-week-old normotensive Wistar Kyoto (WKY), spo…
View article: Bilateral middle cerebellar peduncle lesions in Wernicke's encephalitis
Bilateral middle cerebellar peduncle lesions in Wernicke's encephalitis Open
View article: Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model
Inhibiting Myostatin Expression by the Antisense Oligonucleotides Improves Muscle Wasting in a Chronic Kidney Disease Mouse Model Open
Sarcopenia, a serious consequence of chronic kidney disease (CKD), is driven by elevated myostatin (MSTN), a key inhibitor of muscle growth. This study explored the potential of an MSTN-specific antisense oligonucleotide (ASO) in reversing…
View article: A case of posterior and reversible encephalopathy syndrome in a patient previously undiagnosed with lupus nephritis
A case of posterior and reversible encephalopathy syndrome in a patient previously undiagnosed with lupus nephritis Open
Posterior reversible encephalopathy syndrome (PRES) is a rare clinico-neuroradiologic disease associated with various conditions, such as hypertension, eclampsia, chronic kidney disease, and autoimmune diseases. Here, we present the case o…
View article: An autopsy case of non-drug related progressive multifocal leukoencephalopathy in a background of rheumatoid arthritis
An autopsy case of non-drug related progressive multifocal leukoencephalopathy in a background of rheumatoid arthritis Open
A 56-year-old male subject was presented with a two-month history of dysarthria and gait disturbance. T2-weighted MRI revealed high signal intensity in the right cerebellar hemisphere, pons, and bilateral middle cerebellar pedun…
View article: High Risk of Intracranial Major Artery Stenosis and Ischaemic Stroke in Familial Hypercholesterolemia in Japan: A Comparative Study with a Brain Checkup Cohort
High Risk of Intracranial Major Artery Stenosis and Ischaemic Stroke in Familial Hypercholesterolemia in Japan: A Comparative Study with a Brain Checkup Cohort Open
View article: Successful Resection of Small Intestinal Stenosis After Treatment With an Immune Checkpoint Inhibitor for Metastatic Lung Cancer in the Small Intestine: A Case Report
Successful Resection of Small Intestinal Stenosis After Treatment With an Immune Checkpoint Inhibitor for Metastatic Lung Cancer in the Small Intestine: A Case Report Open
View article: Fusobacterium in oral bacterial flora relates with asymptomatic brain lesions
Fusobacterium in oral bacterial flora relates with asymptomatic brain lesions Open
View article: A Cationic Zn-Phthalocyanine Turns Alzheimer’s Amyloid β Aggregates into Non-Toxic Oligomers and Inhibits Neurotoxicity in Culture
A Cationic Zn-Phthalocyanine Turns Alzheimer’s Amyloid β Aggregates into Non-Toxic Oligomers and Inhibits Neurotoxicity in Culture Open
Amyloid β peptide (Aβ) aggregation and deposition are considered the main causes of Alzheimer’s disease. In a previous study, we demonstrated that anionic Zn-phthalocyanine (ZnPc) can interact with the Aβ peptide and inhibit the fibril-for…
View article: Periodontal care by the improvement of lifestyle toward Health Japan 21 (the third term)
Periodontal care by the improvement of lifestyle toward Health Japan 21 (the third term) Open
View article: The Role of the Vascular System in Degenerative Diseases: Mechanisms and Implications
The Role of the Vascular System in Degenerative Diseases: Mechanisms and Implications Open
Degenerative diseases, encompassing a wide range of conditions affecting various organ systems, pose significant challenges to global healthcare systems. This comprehensive review explores the intricate interplay between the vascular syste…
View article: Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats
Effect of high-fat diet on cerebral pathological changes of cerebral small vessel disease in SHR/SP rats Open
View article: Correction: Shibly et al. Analysis of Cerebral Small Vessel Changes in AD Model Mice. Biomedicines 2023, 11, 50
Correction: Shibly et al. Analysis of Cerebral Small Vessel Changes in AD Model Mice. Biomedicines 2023, 11, 50 Open
In the original publication [...]
View article: A Retrospective Study of Non-small-cell Lung Cancer Patients with Interstitial Lung Disease Treated with Docetaxel Plus Ramucirumab Combination Therapy
A Retrospective Study of Non-small-cell Lung Cancer Patients with Interstitial Lung Disease Treated with Docetaxel Plus Ramucirumab Combination Therapy Open
目的．間質性肺炎合併肺癌に対する化学療法は確立しておらず，経験的治療が行われていることが多い．二次治療以降においては一次治療以上に報告が少なく，当院において二次治療以降でドセタキセル＋ラムシルマブを用いた症例群を報告する．また，間質性肺炎増悪と血管内皮増殖因子の関連が示唆されており，血管新生阻害薬であるラムシルマブを併用することとドセタキセル単剤の安全性を比較・検討する．方法．2017年4月から2021年4月の期間で間質性肺炎合併非小細胞肺癌に対して，二次治療以降でドセタキ…
View article: Time required for psychological testing of dementia is useful for predicting asymptomatic brain lesions: validation using CADi2
Time required for psychological testing of dementia is useful for predicting asymptomatic brain lesions: validation using CADi2 Open
Cognitive test duration is related to brain lesions. However, few studies have addressed automated timing. CADi2 is a cognitive evaluation software. This study aimed to evaluate the use of automatically calculating the time required to ans…
View article: Meningoencephalomyelitis Caused by <i>Brucella canis</i>: A Case Report and Literature Review
Meningoencephalomyelitis Caused by <i>Brucella canis</i>: A Case Report and Literature Review Open
Human brucellosis, one of the most common zoonoses worldwide, is rare in Japan. Brucella canis is the specific pathogen of human brucellosis carried by dogs. According to an epidemiological study of B. canis infection in Japan, B. canis is…
View article: Relationship Between Oral Health, Quality of Life, and Comprehensive Health Literacy in Community-Dwelling Older Adults
Relationship Between Oral Health, Quality of Life, and Comprehensive Health Literacy in Community-Dwelling Older Adults Open
View article: Alzheimer’s Amyloid β Peptide Induces Angiogenesis in an Alzheimer’s Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions
Alzheimer’s Amyloid β Peptide Induces Angiogenesis in an Alzheimer’s Disease Model Mouse through Placental Growth Factor and Angiopoietin 2 Expressions Open
Increased angiogenesis, especially the pathological type, has been documented in Alzheimer’s disease (AD) brains, and it is considered to be activated due to a vascular dysfunction-mediated hypoxic condition. To understand the role of the …
View article: Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults
Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults Open
Recent evidence suggests that trimethylamine-N-oxide (TMAO), a metabolite of L-carnitine and choline, is linked to atherosclerosis and cardiovascular diseases. As TMAO content is very high in fish, we raised the following question: why do …
View article: Altered Feedback-Related Negativity in Mild Cognitive Impairment
Altered Feedback-Related Negativity in Mild Cognitive Impairment Open
Introduction: Feedback-related negativity (FRN) is electrical brain activity related to the function of monitoring behavior and its outcome. FRN is generated by negative feedback input, such as punishment or monetary loss, and its potentia…
View article: iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes
iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes Open
Alzheimer’s disease (AD) is a common dementia disease in the elderly. To get a better understanding of the pathophysiology, we performed a proteomic analysis of the urine exosomes (U-exo) in AD model mice (J20). The polymer precipitation m…
View article: Analysis of Cerebral Small Vessel Changes in AD Model Mice
Analysis of Cerebral Small Vessel Changes in AD Model Mice Open
Amyloid β (Aβ) peptide is deposited in the brains of sporadic Alzheimer’s disease (AD) due to impaired vessel-dependent clearance. To understand the mechanisms, we investigated time-dependent cerebrovascular changes in AD model mice. Cereb…
View article: Respiratory frequency-tunable dynamic imaging for lung function: New exam method using chest X-ray cine imaging considering various respiratory diseases
Respiratory frequency-tunable dynamic imaging for lung function: New exam method using chest X-ray cine imaging considering various respiratory diseases Open
Objectives A convenient way to conduct pulmonary function tests while preventing infectious diseases was proposed, together with countermeasures for severe coronavirus disease 2019 (COVID-19). The correlation between diagnosis result and d…
View article: Distinctive nail pattern following androgen replacement therapy
Distinctive nail pattern following androgen replacement therapy Open
Introduction A distinctive nail pattern in a patient undergoing androgen replacement therapy is presented hereby. Case presentation A 47‐year‐old male patient noticed a peculiar “washboard‐like” pattern on his fingernails. He had been unde…
View article: Practical Radiation Protection for Interventional Radiologist
Practical Radiation Protection for Interventional Radiologist Open
As per the International Commission on Radiological Protection 2010 recommendation, it was stated that "interventional radiologists performing difficult procedures with high workloads may be exposed to high doses" and that education and tr…
View article: Pulse pressure is associated with cognitive performance in Japanese non-demented population: a cross-sectional study
Pulse pressure is associated with cognitive performance in Japanese non-demented population: a cross-sectional study Open