Takeshi Nagasaka
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View article: A machine-learning powered liquid biopsy predicts response to Paclitaxel plus Ramucirumab in advanced gastric cancer: Results from the prospective IVY trial
A machine-learning powered liquid biopsy predicts response to Paclitaxel plus Ramucirumab in advanced gastric cancer: Results from the prospective IVY trial Open
Background Paclitaxel plus ramucirumab (PTX + RAM) is a widely used second-line treatment for advanced gastric cancer, yet no validated biomarkers exist to predict therapeutic response. Identifying non-invasive predictors could enable pati…
View article: Circulating microRNAs differentiate nociceptive and nociplastic pain: An exploratory study
Circulating microRNAs differentiate nociceptive and nociplastic pain: An exploratory study Open
This pilot study suggests that circulating miRNAs may aid in differentiating nociceptive and nociplastic pain mechanisms and tracking treatment effects. While preliminary, these findings support the potential utility of miRNA-based biomark…
View article: Detection of <i>KRAS</i> Mutations Using Extracellular Vesicle <scp>DNA</scp> in Colorectal Cancer Patients
Detection of <i>KRAS</i> Mutations Using Extracellular Vesicle <span>DNA</span> in Colorectal Cancer Patients Open
Liquid biopsy using circulating tumor DNA (ctDNA) is useful for precision medicine and molecular‐guided oncology; however, its sensitivity is insufficient. We focused on DNA in extracellular vesicles (evDNA) as a new target for liquid biop…
View article: Ramucirumab in second‑line advanced colorectal cancer therapy: A study on therapeutic outcomes and hepatic sinusoidal platelet aggregation
Ramucirumab in second‑line advanced colorectal cancer therapy: A study on therapeutic outcomes and hepatic sinusoidal platelet aggregation Open
The present study investigated the role of ramucirumab (RAM) in treating liver metastases (LMs) as a second-line or salvage treatment in patients with advanced CRC. Of the 36 patients, 21 (58%) received RAM plus folinic acid, fluorouracil …
View article: Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles
Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles Open
This study investigates methylation patterns in circulating cell-free DNA (ccfDNA) for their potential role in colorectal cancer (CRC) detection and the monitoring of treatment response. Through methylation microarrays and quantitative PCR…
View article: 1585P The impact of platinum-induced peripheral neuropathy (PN) in first-line treatment on PN and efficacy in second-line paclitaxel (PTX)-based chemotherapy for unresectable advanced gastric cancer (AGC): A prospective observational multicenter study - IVY study
1585P The impact of platinum-induced peripheral neuropathy (PN) in first-line treatment on PN and efficacy in second-line paclitaxel (PTX)-based chemotherapy for unresectable advanced gastric cancer (AGC): A prospective observational multicenter study - IVY study Open
View article: Supplementary Movie S2 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Supplementary Movie S2 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
Supplementary Movie S2 - MOV file 4338K, Time-lapse imaging of FUCCI-expressing tumor spheres cultured in three-dimensional culture without serum (3D culture), or tumor sphere in monolayer culture with serum (monolayer culture). Images wer…
View article: Supplementary methods and figure legends from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Supplementary methods and figure legends from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer Open
Supplementary methods and figure legends
View article: Supplementary Movie S3 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Supplementary Movie S3 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
Supplementary Movie S3 - MOV file 6227K, Time-lapse imaging of treatment dynamics of FUCCI-expressing dormant tumor spheres treated with OBP-301 or conventional therapy in three-dimensional culture. Tumor spheres were treated with mock (up…
View article: Data from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening
Data from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening Open
Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, but currently available noninvasive screening programs have achieved only a modest decrease in mortality. MicroRNAs (miRNA) play an importan…
View article: Supplementary Movie S2 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Supplementary Movie S2 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
Supplementary Movie S2 - MOV file 4338K, Time-lapse imaging of FUCCI-expressing tumor spheres cultured in three-dimensional culture without serum (3D culture), or tumor sphere in monolayer culture with serum (monolayer culture). Images wer…
View article: Supplementary Movie S1 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Supplementary Movie S1 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
Supplementary Movie S1- MOV file 6383K, Time-lapse imaging of FUCCI-expressing CD133+ cells treated with OBP-301 or control on monolayer culture. Images were acquired every 20 min. The playback speed is 10, 800 x real time. Total imaging t…
View article: Supplementary Information from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Supplementary Information from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
- PDF file 1712K, Supplementary Methods Fig. S1. OBP-301 efficiently kills CD133+ cells from MKN7 cells resistant to conventional therapies. Fig. S2. CD133+ CS-like cells can produce CD133+ CS-like cells and CD133- non-CS-like cells. Fig. …
View article: Data from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Data from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
Purpose: Because chemoradiotherapy selectively targets proliferating cancer cells, quiescent cancer stem–like cells are resistant. Mobilization of the cell cycle in quiescent leukemia stem cells sensitizes them to cell death signals…
View article: Supplementary Table 1 from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening
Supplementary Table 1 from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening Open
Supplementary Table 1 from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening
View article: Supplementary Movie S1 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Supplementary Movie S1 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
Supplementary Movie S1- MOV file 6383K, Time-lapse imaging of FUCCI-expressing CD133+ cells treated with OBP-301 or control on monolayer culture. Images were acquired every 20 min. The playback speed is 10, 800 x real time. Total imaging t…
View article: Supplementary Information from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Supplementary Information from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
- PDF file 1712K, Supplementary Methods Fig. S1. OBP-301 efficiently kills CD133+ cells from MKN7 cells resistant to conventional therapies. Fig. S2. CD133+ CS-like cells can produce CD133+ CS-like cells and CD133- non-CS-like cells. Fig. …
View article: Supplementary Table 1 from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening
Supplementary Table 1 from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening Open
Supplementary Table 1 from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening
View article: Supplementary figures from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Supplementary figures from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer Open
Supplementary figures 1-5
View article: Data from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Data from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer Open
Purpose: Colorectal cancer is one of the most common malignancies worldwide. Recently, a novel circular RNA, ciRS-7, was proposed to be a potential miR-7 sponge. As miR-7, a putative tumor-suppressor, regulates the expression of sev…
View article: Juvenile colon cancer diagnosed by onset of intussusception: a case report suggestive of Lynch syndrome treated with laparoscopic colectomy
Juvenile colon cancer diagnosed by onset of intussusception: a case report suggestive of Lynch syndrome treated with laparoscopic colectomy Open
Background : One characteristic of Lynch syndrome, which is caused by germline mutations in a group of genes encoding mismatch repair proteins, is the early onset of colorectal cancer. Here, we report a rare case of juvenile colon cancer, …
View article: Supplementary figures from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Supplementary figures from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer Open
Supplementary figures 1-5
View article: Supplementary methods and figure legends from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Supplementary methods and figure legends from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer Open
Supplementary methods and figure legends
View article: Data from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Data from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer Open
Purpose: Colorectal cancer is one of the most common malignancies worldwide. Recently, a novel circular RNA, ciRS-7, was proposed to be a potential miR-7 sponge. As miR-7, a putative tumor-suppressor, regulates the expression of sev…
View article: Data from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening
Data from Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening Open
Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths, but currently available noninvasive screening programs have achieved only a modest decrease in mortality. MicroRNAs (miRNA) play an importan…
View article: Data from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Data from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
Purpose: Because chemoradiotherapy selectively targets proliferating cancer cells, quiescent cancer stem–like cells are resistant. Mobilization of the cell cycle in quiescent leukemia stem cells sensitizes them to cell death signals…
View article: Supplementary tables from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Supplementary tables from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer Open
Supplementary tables
View article: Supplementary tables from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Supplementary tables from Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer Open
Supplementary tables
View article: Supplementary Movie S3 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases
Supplementary Movie S3 from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem–like Cells in S/G<sub>2</sub>/M Phases Open
Supplementary Movie S3 - MOV file 6227K, Time-lapse imaging of treatment dynamics of FUCCI-expressing dormant tumor spheres treated with OBP-301 or conventional therapy in three-dimensional culture. Tumor spheres were treated with mock (up…
View article: Supplementary Figures 1-2 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer
Supplementary Figures 1-2 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer Open
Supplementary Figures 1-2 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer