Tatsutoshi Nakahata
YOU?
Author Swipe
View article: Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice
Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice Open
Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human…
View article: Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes
Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes Open
View article: Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice
Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice Open
Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human CD34
View article: Screening Station, a novel laboratory automation system for physiologically relevant cell-based assays
Screening Station, a novel laboratory automation system for physiologically relevant cell-based assays Open
Due to their physiological relevance, cell-based assays using human-induced pluripotent stem cell (iPSC)-derived cells are a promising in vitro pharmacological evaluation system for drug candidates. However, cell-based assays involve compl…
View article: Data from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia
Data from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia Open
S-phase progression of the cell cycle is accelerated in tumors through various genetic abnormalities, and, thus, pharmacologic inhibition of altered cell-cycle progression would be an effective strategy to control tumors. In the current st…
View article: Data from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia
Data from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia Open
S-phase progression of the cell cycle is accelerated in tumors through various genetic abnormalities, and, thus, pharmacologic inhibition of altered cell-cycle progression would be an effective strategy to control tumors. In the current st…
View article: Supplementary Table from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia
Supplementary Table from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia Open
Supplementary Table S1-S5. Table S1. Characteristics leukemia cell lines. Table S2. List of primary antibodies used for Western blot analysis. Table S3. List of Taqman probe for real-time RT-PCR analysis. Table S4. Sequences of siRNA. Tabl…
View article: Supplementary Figure from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia
Supplementary Figure from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia Open
Supplementary Fig. S1-S5. Fig. S1. Anti-leukemic activity of PD0332991 against Ph+ lymphoid leukemia cell lines. Fig. S2. Effect of cytokines and PD0332991 on cell growth of Ph+ lymphoid leukemia cell lines. Fig. S3. Anti-leukemic activity…
View article: Supplementary Figure from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia
Supplementary Figure from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia Open
Supplementary Fig. S1-S5. Fig. S1. Anti-leukemic activity of PD0332991 against Ph+ lymphoid leukemia cell lines. Fig. S2. Effect of cytokines and PD0332991 on cell growth of Ph+ lymphoid leukemia cell lines. Fig. S3. Anti-leukemic activity…
View article: Supplementary Table from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia
Supplementary Table from Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome–Positive Lymphoid Leukemia Open
Supplementary Table S1-S5. Table S1. Characteristics leukemia cell lines. Table S2. List of primary antibodies used for Western blot analysis. Table S3. List of Taqman probe for real-time RT-PCR analysis. Table S4. Sequences of siRNA. Tabl…
View article: Development of an osteosarcoma model with <i>MYCN</i> amplification and <i>TP53</i> mutation in hiPS cell‐derived neural crest cells
Development of an osteosarcoma model with <i>MYCN</i> amplification and <i>TP53</i> mutation in hiPS cell‐derived neural crest cells Open
Mesenchymal stem cell‐ or osteoblast‐derived osteosarcoma is the most common malignant bone tumor. Its highly metastatic malignant phenotypes, which are often associated with a poor prognosis, have been correlated with the modulation of TP…
View article: SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis Open
Spinal muscular atrophy (SMA) is a congenital neuromuscular disease caused by the mutation or deletion of the survival motor neuron 1 (SMN1) gene. Although the primary cause of progressive muscle atrophy in SMA has classically been conside…
View article: RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors Open
View article: Author Correction: A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
Author Correction: A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice Open
View article: A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice
A RUNX-targeted gene switch-off approach modulates the BIRC5/PIF1-p21 pathway and reduces glioblastoma growth in mice Open
View article: The first Japanese biobank of patient‐derived pediatric acute lymphoblastic leukemia xenograft models
The first Japanese biobank of patient‐derived pediatric acute lymphoblastic leukemia xenograft models Open
A lack of practical resources in Japan has limited preclinical discovery and testing of therapies for pediatric relapsed and refractory acute lymphoblastic leukemia (ALL), which has poor outcomes. Here, we established 57 patient‐derived xe…
View article: SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis
SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis Open
Spinal muscular atrophy (SMA) is a congenital neuromuscular disease caused by the mutation or deletion of survival motor neuron 1 ( SMN1 ) gene. Although the primary cause of progressive muscle atrophy in SMA has classically been considere…
View article: Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts
Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythroblasts Open
The aryl hydrocarbon receptor (AHR) plays an important role during mammalian embryo development. Inhibition of AHR signaling promotes the development of hematopoietic stem/progenitor cells. AHR also regulates the functional maturation of b…
View article: CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia
CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia Open
View article: RUNX1 transactivates <i>BCR‐ABL1</i> expression in Philadelphia chromosome positive acute lymphoblastic leukemia
RUNX1 transactivates <i>BCR‐ABL1</i> expression in Philadelphia chromosome positive acute lymphoblastic leukemia Open
The emergence of tyrosine kinase inhibitors as part of a front‐line treatment has greatly improved the clinical outcome of the patients with Ph + acute lymphoblastic leukemia (ALL). However, a portion of them still become refractory to the…
View article: CD146 is a potential immunotarget for neuroblastoma
CD146 is a potential immunotarget for neuroblastoma Open
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to arise from neural crest‐derived immature cells. The prognosis of patients with high‐risk or recurrent/refractory neuroblastoma remains quite poor despite i…
View article: N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21
N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21 Open
View article: Efficacy of a combination therapy targeting CDK4/6 and autophagy in a mouse xenograft model of t(8;21) acute myeloid leukemia
Efficacy of a combination therapy targeting CDK4/6 and autophagy in a mouse xenograft model of t(8;21) acute myeloid leukemia Open
One of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML) is t(8;21). Although patients with t(8;21) AML have a more favorable prognosis than other cytogenetic subgroups, relapse is still common and novel therapeut…
View article: Generation of germ-free common marmosets
Generation of germ-free common marmosets Open
Recent studies using germ-free mice have demonstrated that microbiota have functional roles in host homeostasis1,2. However, the phylogenetic distance between rodents and humans translates into differences in their metabolism, immune respo…
View article: Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes
Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes Open
The aryl hydrocarbon receptor (AHR) plays an important role during mammalian embryo development. Inhibition of AHR signaling promotes the development of hematopoietic stem/progenitor cells. AHR also regulates the functional maturation of b…
View article: RUNX inhibitor suppresses graft‐versus‐host disease through targeting <i>RUNX‐NFATC2</i> axis
RUNX inhibitor suppresses graft‐versus‐host disease through targeting <i>RUNX‐NFATC2</i> axis Open
Patients with refractory graft‐versus‐host disease (GVHD) have a dismal prognosis. Therefore, novel therapeutic targets are still needed to be identified. Runt‐related transcriptional factor (RUNX) family transcription factors are essentia…
View article: Correction: Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity
Correction: Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity Open
[This corrects the article DOI: 10.1371/journal.pone.0237030.].
View article: Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification
Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification Open
Children with Down syndrome (DS) are susceptible to two blood disorders, transient abnormal myelopoiesis (TAM) and Down syndrome-associated acute megakaryocytic leukemia (DS-AMKL). Mutations in GATA binding protein 1 ( GATA1 ) have been id…
View article: Establishment of a Robust Platform for Induced Pluripotent Stem Cell Research Using Maholo LabDroid
Establishment of a Robust Platform for Induced Pluripotent Stem Cell Research Using Maholo LabDroid Open
Induced pluripotent stem cells (iPSCs) are attractive for use in early drug discovery because they can differentiate into any cell type. Maintenance cultures and differentiation processes for iPSCs, however, require a high level of technic…
View article: Author Correction: Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors
Author Correction: Pluripotent stem cell model of Shwachman–Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors Open