María T. Abreu
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View article: Integrative Epigenomic and Targeted Protein Analysis in MRONJ: Correlating DNA Methylation with Bone Biomarkers
Integrative Epigenomic and Targeted Protein Analysis in MRONJ: Correlating DNA Methylation with Bone Biomarkers Open
Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse effect of antiresorptive agents, including bisphosphonates (BPs) and denosumab (DMB). We conducted a case–control epigenome-wide association study (EWAS) of 24 cancer …
View article: Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database Open
Incomplete penetrance, or absence of disease phenotype in an individual with a disease-associated variant, is a major challenge in variant interpretation. Studying individuals with apparent incomplete penetrance can shed light on underlyin…
View article: A Short Dietary Screener Captures Food Items and Dietary Patterns That Associate With Inflammation in Inflammatory Bowel Disease.
A Short Dietary Screener Captures Food Items and Dietary Patterns That Associate With Inflammation in Inflammatory Bowel Disease. Open
The DSQ is a short dietary screener that can identify food items that associate with inflammation in IBD. Our findings suggest that the DSQ is a feasible tool for use in clinical practice to assess, guide, and track dietary recommendations…
View article: Relationship of Intestinal Ultrasound With Clinical, Biochemical, and Endoscopic Disease Severity in Acute Severe Ulcerative Colitis: A Blinded, Prospective Study
Relationship of Intestinal Ultrasound With Clinical, Biochemical, and Endoscopic Disease Severity in Acute Severe Ulcerative Colitis: A Blinded, Prospective Study Open
INTRODUCTION: The utility of intestinal ultrasound (IUS) for acute severe ulcerative colitis (ASUC) is understudied. We correlated IUS to clinical, biochemical, and endoscopic disease severity in ASUC. METHODS: In a blinded, prospective st…
View article: Acordo de Não Persecução Penal e a Linguagem da Efetividade: análise crítica das medidas aplicadas nacionalmente (jan-jun/2021)
Acordo de Não Persecução Penal e a Linguagem da Efetividade: análise crítica das medidas aplicadas nacionalmente (jan-jun/2021) Open
O presente artigo analisa o Acordo de Não Persecução Penal (ANPP), instituído pela Lei n.º 13.964/19 – o chamado Pacote Anticrime –, com foco na avaliação da (in)efetividade das medidas aplicadas nacionalmente entre janeiro e junho de 2021…
View article: A emancipação feminina no mercado de trabalho: linguagem, gênero e políticas públicas na Lei 14.457/2022
A emancipação feminina no mercado de trabalho: linguagem, gênero e políticas públicas na Lei 14.457/2022 Open
Este artigo analisa criticamente a relação entre linguagem, gênero e trabalho, com ênfase na formulação e implementação de políticas públicas voltadas à emancipação feminina no mercado de trabalho, à luz da Lei n.º 14.457/2022. A partir de…
View article: A comunicação para inserção dos jovens do Projeto Basketito no mercado de trabalho
A comunicação para inserção dos jovens do Projeto Basketito no mercado de trabalho Open
O presente artigo busca demonstrar a importância da preparação dos jovens para a inserção no mercado de trabalho, a partir de algumas das vivências desenvolvidas no projeto de demanda induzida “Compreender e qualificar para potencializar h…
View article: A produção linguística da alienação parental: violência simbólica e de gênero nos discursos judiciais
A produção linguística da alienação parental: violência simbólica e de gênero nos discursos judiciais Open
O presente estudo analisa a Lei n.º 12.318/10 – conhecida como Lei da Alienação Parental – a partir de uma perspectiva crítica que considera os efeitos da linguagem jurídica na reprodução de violências simbólicas e de gênero no contexto da…
View article: DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis
DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis Open
Background Inflammatory bowel diseases (IBDs) are characterised by dysbiosis and a leaky gut. The NADPH oxidase dual oxidase 2 (DUOX2) is upregulated in patients with IBD, yet its role in driving the disease remains unclear. Objective We i…
View article: Os Os desafios jurídicos e a regulamentação das criptomoedas
Os Os desafios jurídicos e a regulamentação das criptomoedas Open
The article addresses the impact of cryptocurrencies, especially Bitcoin, on economics and law by challenging traditional concepts of currency. It begins with an analysis of the classical definition of currency and how cryptocurrencies fac…
View article: Deep Sequencing of Crohn’s Disease Lamina Propria Phagocytes Identifies Pathobionts and Correlates With Pro-Inflammatory Gene Expression
Deep Sequencing of Crohn’s Disease Lamina Propria Phagocytes Identifies Pathobionts and Correlates With Pro-Inflammatory Gene Expression Open
Background Crohn’s disease (CD) is characterized by an inflammatory response to gut microbiota. Macrophages and dendritic cells play an active role in CD inflammation. Specific microbiota have been implicated in the pathogenesis of ileal C…
View article: Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT Open
The current approach to minimize transplant-associated complications, including graft-versus-host disease (GVHD) includes long-term pharmacological immune suppression frequently accompanied by unwanted side effects. Advances in targeted im…
View article: Guidance for Fecal Microbiota Transplantation Trials in Ulcerative Colitis: The Second ROME Consensus Conference
Guidance for Fecal Microbiota Transplantation Trials in Ulcerative Colitis: The Second ROME Consensus Conference Open
Background Fecal microbiota transplantation (FMT) is emerging as a potential treatment modality for individuals living with inflammatory bowel disease (IBD). Despite its promise, the effectiveness of FMT for treating IBD, particularly for …
View article: IDEntifying PAtients with Suspicion of Infection in the ED Who Have Low Disease Severity Using Midregional Proadrenomedullin (MR-proADM) – A Pragmatic Pivotal Randomized Controlled Trial
IDEntifying PAtients with Suspicion of Infection in the ED Who Have Low Disease Severity Using Midregional Proadrenomedullin (MR-proADM) – A Pragmatic Pivotal Randomized Controlled Trial Open
View article: International consensus statement on microbiome testing in clinical practice
International consensus statement on microbiome testing in clinical practice Open
View article: Oxidized Low-Density Lipoprotein Induces Reactive Oxygen Species-Dependent Proliferation of Intestinal Epithelial Cells
Oxidized Low-Density Lipoprotein Induces Reactive Oxygen Species-Dependent Proliferation of Intestinal Epithelial Cells Open
Background/Objectives: Oxidized low-density lipoprotein (ox-LDL) is a proinflammatory particle associated with various diseases and affects cell proliferation and viability in multiple cell types. However, its impact on intestinal epitheli…
View article: P162 Neuropsychiatric symptoms in patients treated with novel hormonal agents in prostate cancer – real word experience from a single centre
P162 Neuropsychiatric symptoms in patients treated with novel hormonal agents in prostate cancer – real word experience from a single centre Open
View article: Metaproteomics reveals diet-induced changes in gut microbiome function according to Crohn’s disease location
Metaproteomics reveals diet-induced changes in gut microbiome function according to Crohn’s disease location Open
View article: A Novel Microbial Dysbiosis Index and Intestinal Microbiota-Associated Markers as Tools of Precision Medicine in Inflammatory Bowel Disease Paediatric Patients
A Novel Microbial Dysbiosis Index and Intestinal Microbiota-Associated Markers as Tools of Precision Medicine in Inflammatory Bowel Disease Paediatric Patients Open
Recent evidence indicates that the gut microbiota (GM) has a significant impact on the inflammatory bowel disease (IBD) progression. Our aim was to investigate the GM profiles, the Microbial Dysbiosis Index (MDI) and the intestinal microbi…
View article: A high-fiber, low-fat diet improves the symptoms and metabolic profile of patients with Crohn’s disease
A high-fiber, low-fat diet improves the symptoms and metabolic profile of patients with Crohn’s disease Open
Background Crohn’s disease (CD) is characterized by intestinal inflammation. Diet is a risk factor for inflammatory bowel diseases such as CD and represents a promising adjunctive treatment, yet there are few well-controlled dietary interv…
View article: An IL-17-DUOX2 axis controls gastrointestinal colonization by<i>Candida albicans</i>
An IL-17-DUOX2 axis controls gastrointestinal colonization by<i>Candida albicans</i> Open
Candida albicans is a ubiquitous fungus in the human gut microbiome as well as a prevalent cause of opportunistic mucosal and systemic disease. There is currently little understanding, however, as to how crosstalk between C. albicans and t…
View article: The Effect of Etrasimod on Fecal Calprotectin and High-sensitivity C-reactive Protein: Results From the ELEVATE UC Clinical Program
The Effect of Etrasimod on Fecal Calprotectin and High-sensitivity C-reactive Protein: Results From the ELEVATE UC Clinical Program Open
Background Biomarkers offer potential alternatives to endoscopies in monitoring ulcerative colitis (UC) progression and therapeutic response. This post hoc analysis of the ELEVATE UC clinical program assessed potential predictive values of…
View article: Early and Sustained Symptom Control with Mirikizumab in Patients with Ulcerative Colitis in the Phase 3 LUCENT Programme
Early and Sustained Symptom Control with Mirikizumab in Patients with Ulcerative Colitis in the Phase 3 LUCENT Programme Open
Background and Aims Ulcerative colitis [UC], a chronic inflammatory bowel disease, may manifest with symptoms of increased stool frequency [SF], rectal bleeding [RB], bowel urgency [BU], abdominal pain [AP], and fatigue. Mirikizumab, an an…
View article: Stromal-Like Cells Are Found in Peripheral Blood of Patients With Inflammatory Bowel Disease and Correlate With Immune Activation State
Stromal-Like Cells Are Found in Peripheral Blood of Patients With Inflammatory Bowel Disease and Correlate With Immune Activation State Open
INTRODUCTION: Recent studies have identified a critical role of stromal-immune cell interactions in immunity and immune tolerance. Transcriptomic profiling has implicated stromal cells in immune-mediated disorders including the 2 common fo…
View article: Etrasimod for the Treatment of Ulcerative Colitis: Analysis of Infection Events from the ELEVATE UC Clinical Programme
Etrasimod for the Treatment of Ulcerative Colitis: Analysis of Infection Events from the ELEVATE UC Clinical Programme Open
Background and Aims Infections are a safety concern in patients with ulcerative colitis [UC]. Etrasimod is an oral, once daily [QD], selective sphingosine 1-phosphate [S1P]1,4,5 receptor modulator for the treatment of moderately to severel…
View article: IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy
IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy Open
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease.…
View article: Extrachromosomal Circular DNA: An Emerging Potential Biomarker for Inflammatory Bowel Diseases?
Extrachromosomal Circular DNA: An Emerging Potential Biomarker for Inflammatory Bowel Diseases? Open
Inflammatory bowel disease (IBD) comprising ulcerative colitis and Crohn’s disease is a chronic immune-mediated disease which affects the gastrointestinal tract with a relapsing and remitting course, causing lifelong morbidity. IBD pathoge…
View article: Two-Year Efficacy and Safety of Mirikizumab Following 104 Weeks of Continuous Treatment for Ulcerative Colitis: Results From the LUCENT-3 Open-Label Extension Study
Two-Year Efficacy and Safety of Mirikizumab Following 104 Weeks of Continuous Treatment for Ulcerative Colitis: Results From the LUCENT-3 Open-Label Extension Study Open
Background Mirikizumab, a p19-directed interleukin-23 monoclonal antibody, is efficacious in inducing clinical remission at week 12 (W12) and maintaining clinical remission at W52 in patients with moderately to severely active ulcerative c…
View article: A18 EARLY LIFE EXPOSURE TO PARENTAL CROHN'S DISEASE IS ASSOCIATED WITH GUT MICROBIAL COMPOSITION AND FUNCTION, GUT PERMEABILITY AND INCREASED RISK OF FUTURE CROHN'S DISEASE
A18 EARLY LIFE EXPOSURE TO PARENTAL CROHN'S DISEASE IS ASSOCIATED WITH GUT MICROBIAL COMPOSITION AND FUNCTION, GUT PERMEABILITY AND INCREASED RISK OF FUTURE CROHN'S DISEASE Open
Background Previous studies show that offspring of persons with Crohn’s disease (CD) have a 7-fold higher risk of incident CD than the general population. Newborns of women with CD (vs healthy women) have altered stool microbiome compositi…
View article: Safety of Ustekinumab in Inflammatory Bowel Disease: Pooled Safety Analysis Through 5 Years in Crohn’s Disease and 4 Years in Ulcerative Colitis
Safety of Ustekinumab in Inflammatory Bowel Disease: Pooled Safety Analysis Through 5 Years in Crohn’s Disease and 4 Years in Ulcerative Colitis Open
Background and Aims Previously published long-term safety data reported a favourable ustekinumab safety profile for the treatment of inflammatory bowel disease [IBD]. We present the final cumulative safety data from pooled ustekinumab IBD …