Timothy E. O’Connor
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View article: Outcomes of brexucabtagene autoleucel in patients with relapsed/refractory acute lymphoblastic leukemia with CNS involvement
Outcomes of brexucabtagene autoleucel in patients with relapsed/refractory acute lymphoblastic leukemia with CNS involvement Open
Patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) with central nervous system (CNS) involvement (CNS B-ALL) have poor outcomes and were frequently excluded from CD19-targeting chimeric antigen receptor (CA…
View article: Open laminectomy vs. minimally invasive laminectomy for lumbar spinal stenosis: a review
Open laminectomy vs. minimally invasive laminectomy for lumbar spinal stenosis: a review Open
Objectives Lumbar spinal stenosis (LSS) refers to a narrowing of the space within the spinal canal, which can occur at any level but is most common in the lumbar spine. Open laminectomy and minimally invasive laminectomy (MIL) procedures a…
View article: NGS MRD Negativity on Day 28 after Brexu Cel in Adults with R/R ALL Is Associated with Favorable Progression Free Survival
NGS MRD Negativity on Day 28 after Brexu Cel in Adults with R/R ALL Is Associated with Favorable Progression Free Survival Open
Introduction: Brexucabtagene autoleucel (brexu cel) is a CD19-targeted chimeric antigen receptor (CAR) T cell therapy approved for the treatment of adults with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL). Some patients (pt…
View article: Impact of prior inotuzumab ozogamicin treatment on brexucabtagene autoleucel outcomes in adults with B-cell ALL
Impact of prior inotuzumab ozogamicin treatment on brexucabtagene autoleucel outcomes in adults with B-cell ALL Open
The effect of prior inotuzumab ozogamicin (InO) treatment on brexucabtagene autoleucel (brexu-cel) outcomes remains unclear in adults with acute lymphoblastic leukemia (ALL). We conducted a retrospective multicenter analysis of 189 patient…
View article: NURSING STUDENTS’ RESPONSE TO THE AGE-FRIENDLY HEALTH SYSTEMS 4MS FRAMEWORK CURRICULUM
NURSING STUDENTS’ RESPONSE TO THE AGE-FRIENDLY HEALTH SYSTEMS 4MS FRAMEWORK CURRICULUM Open
Problem There is a shortage of registered nurses, especially those choosing to work in long-term care. Providing interdisciplinary education on age-friendly health care to nursing students offers long-term care as a career option post-grad…
View article: The Impact of Social Determinants of Health on Brexucabtagene Autoleucel Outcomes in Adults with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia
The Impact of Social Determinants of Health on Brexucabtagene Autoleucel Outcomes in Adults with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Open
Background Brexucabtagene autoleucel (brexu-cel) is an autologous anti-CD19 chimeric antigen receptor (CAR-T) cell therapy that recently received U.S. FDA approval as the first CAR-T cell therapy for adults with relapsed/refractory (r/r) B…
View article: Toxicity Profile of Brexucabtagene Autoleucel (brexu-cel; CD19-directed CAR T-cell therapy) in Adult Patients (pts) with Relapsed/Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (B-ALL): Results from a Multicenter Real-World Outcomes Study
Toxicity Profile of Brexucabtagene Autoleucel (brexu-cel; CD19-directed CAR T-cell therapy) in Adult Patients (pts) with Relapsed/Refractory (R/R) B-Cell Acute Lymphoblastic Leukemia (B-ALL): Results from a Multicenter Real-World Outcomes Study Open
Introduction: In October 2021, the FDA approved brexu-cel for the treatment of adults ≥ 18 years old with R/R B-ALL. Following this approval, a consortium of cancer centers was formed across the US to investigate outcomes following commerc…
View article: Evaluation of the Recommended 30 cc/kg Fluid Dose for Patients With Septic Shock and Hypoperfusion With Lactate Greater Than 4 mmol/L
Evaluation of the Recommended 30 cc/kg Fluid Dose for Patients With Septic Shock and Hypoperfusion With Lactate Greater Than 4 mmol/L Open
OBJECTIVES: The Surviving Sepsis Campaign Guidelines recommend fluid administration of 30 cc/kg ideal body weight (IBW) for patients with sepsis and lactate greater than 4 mmol/L within 3 hours of identification. In this study, we explore …
View article: Multicenter analysis of COVID-19 hospitalizations and stacking machine learning algorithms for prediction of high-risk patients
Multicenter analysis of COVID-19 hospitalizations and stacking machine learning algorithms for prediction of high-risk patients Open
Objective To create and validate an ensemble of machine learning algorithms to accurately predict ICU admission or mortality upon initial presentation to the emergency department. Methods This is a retrospective cohort study of a multicent…
View article: Multicenter analysis of immunosuppressive medications on the risk of malignancy following adult solid organ transplantation
Multicenter analysis of immunosuppressive medications on the risk of malignancy following adult solid organ transplantation Open
Objective This study aimed to assess the risk of maintenance immunosuppression on the post-transplant risk of malignancy across all solid organ transplant types. Methods This is a retrospective cohort study from a multicenter hospital syst…
View article: COVID-19 severity and cardiovascular outcomes in SARS-CoV-2-infected patients with cancer and cardiovascular disease
COVID-19 severity and cardiovascular outcomes in SARS-CoV-2-infected patients with cancer and cardiovascular disease Open
Co-morbid CVD/CVRF is associated with higher COVID-19 severity among patients with cancer, particularly those not receiving active cancer therapy. While infrequent, COVID-19 related CV complications were higher in patients with comorbid CV…
View article: Clinical considerations at the intersection of hematopoietic cell transplantation and hereditary hematopoietic malignancy
Clinical considerations at the intersection of hematopoietic cell transplantation and hereditary hematopoietic malignancy Open
In recent years, advances in genetics and the integration of clinical-grade next-generation sequencing (NGS) assays into patient care have facilitated broader recognition of hereditary hematopoietic malignancy (HHM) among clinicians, in ad…
View article: Breakthrough SARS-CoV-2 infections among patients with cancer following two and three doses of COVID-19 mRNA vaccines: a retrospective observational study from the COVID-19 and Cancer Consortium
Breakthrough SARS-CoV-2 infections among patients with cancer following two and three doses of COVID-19 mRNA vaccines: a retrospective observational study from the COVID-19 and Cancer Consortium Open
This study was partly supported by grants from the National Cancer Institute grant number P30 CA068485 to C-YH, YS, SM, JLW; T32-CA236621 and P30-CA046592 to C.R.F; CTSA 2UL1TR001425-05A1 to TMW-D; ACS/FHI Real-World Data Impact Award, P50…
View article: Stagnation in quality of next‐generation sequencing assays for the diagnosis of hereditary hematopoietic malignancies
Stagnation in quality of next‐generation sequencing assays for the diagnosis of hereditary hematopoietic malignancies Open
Hereditary hematopoietic malignancies (HHMs) are inherited syndromes that confer the risk of blood cancer development. With the rapid acceleration of next‐generation sequencing (NGS) into commercial biotechnology markets, HHMs are increasi…
View article: Multicenter analysis of immunosuppressive medications on the subsequent risk of malignancy in solid organ transplant recipients
Multicenter analysis of immunosuppressive medications on the subsequent risk of malignancy in solid organ transplant recipients Open
Solid organ transplant is a curative treatment for end organ disease. However, the immunosuppressive therapy required to prevent graft rejection increases the likelihood of developing a subsequent malignancy. This retrospective cohort stud…
View article: Stagnation in quality of next-generation sequencing assays for the diagnosis of hereditary hematopoietic malignancies
Stagnation in quality of next-generation sequencing assays for the diagnosis of hereditary hematopoietic malignancies Open
Importance Hereditary hematopoietic malignancies (HHMs) are hereditary cancer syndromes that constitute at least 14% of all myeloid malignancies, but genetic assays used to diagnose HHMs have historically been of variable quality. Here, we…
View article: Anatomical and Technical Considerations of Robot-Assisted Cervical Pedicle Screw Placement: A Cadaveric Study
Anatomical and Technical Considerations of Robot-Assisted Cervical Pedicle Screw Placement: A Cadaveric Study Open
Study Design Cadaver study. Objectives Assess the feasibility of robot-assisted cervical pedicle screw (RA-CPS) placement and understand the anatomical considerations of this technique. Methods Four cadaver specimens free from bony patholo…
View article: Microdiscectomy Under Local Anesthesia and Spinal Block in a Pregnant Female
Microdiscectomy Under Local Anesthesia and Spinal Block in a Pregnant Female Open
The surgical plan and the anesthetic approach are vital in determining the proper treatment of lumbar disc herniation in pregnancy. The diagnostic tools available, as well as the anesthetic agents and methods of delivery, vary in pregnant …
View article: Lobar Gross Endobronchial Disease Predicts for Overall Survival and Grade 5 Pulmonary Toxicity in Medically Inoperable Early Stage Non-Small Cell Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy
Lobar Gross Endobronchial Disease Predicts for Overall Survival and Grade 5 Pulmonary Toxicity in Medically Inoperable Early Stage Non-Small Cell Lung Cancer Patients Treated With Stereotactic Body Radiation Therapy Open
Purpose Stereotactic body radiation therapy (SBRT) is considered standard of care for medically inoperable early stage non-small cell lung cancer (ES-NSCLC). Central tumor location is a known risk factor for severe SBRT related toxicity. B…
View article: Continuous Antibiotic Administration Using IRRAflow® Catheter for Treatment of Intracranial Abscess
Continuous Antibiotic Administration Using IRRAflow® Catheter for Treatment of Intracranial Abscess Open
Intracranial abscesses are rare lesions with an incidence of approximately 4 per 1 million people. The optimal surgical management of these lesions is still unclear. We present the case of a patient who was discovered to have an intracrani…
View article: Minimally Invasive Robot-Guided Dual Cortical Bone Trajectory for Adjacent Segment Disease
Minimally Invasive Robot-Guided Dual Cortical Bone Trajectory for Adjacent Segment Disease Open
Here we present a novel application of cortical bone trajectory (CBT) fixation utilizing robotic guidance in a previously instrumented spine with a traditional pedicle screw (PS), obviating the need for a larger posterior incision, reducin…
View article: Accuracy and Efficiency of Fusion Robotics™ Versus Mazor-X™ in Single-Level Lumbar Pedicle Screw Placement
Accuracy and Efficiency of Fusion Robotics™ Versus Mazor-X™ in Single-Level Lumbar Pedicle Screw Placement Open
Introduction There has been a surge in robot utilization in spine surgery over the past five years with the rapid development of new spine robotic platforms. This study aimed to compare a new robotic spine platform from Fusion RoboticsTM (…
View article: Infundibular hemangioblastoma resection: Video case report
Infundibular hemangioblastoma resection: Video case report Open
Background: Hemangioblastomas are benign (World Health Organization Grade I), highly vascular neoplasms commonly associated with Von Hippel-Lindau (VHL) disease.[2] The VHL tumor-suppressor gene, located on chromosome 3, is implicated in s…
View article: Drainage, Irrigation, and Fibrinolytic Therapy (DRIFT) for Adult Intraventricular Hemorrhage Using IRRAflow® Self-Irrigating Catheter
Drainage, Irrigation, and Fibrinolytic Therapy (DRIFT) for Adult Intraventricular Hemorrhage Using IRRAflow® Self-Irrigating Catheter Open
Intraventricular hemorrhage (IVH) is a devastating neurosurgical condition associated with high rates of morbidity and mortality. It can occur as the result of several pathologies and typically presents with mental status changes, neurolog…
View article: Minimally Invasive Approach to Subdural Hematoma Treatment Using IRRAflow Catheter and Middle Meningeal Artery Embolization
Minimally Invasive Approach to Subdural Hematoma Treatment Using IRRAflow Catheter and Middle Meningeal Artery Embolization Open
Chronic subdural hematoma (cSDH) is a common neurosurgical pathology that usually occurs in the seventh decade of life. Patients can present with mental status changes, focal neurologic deficits, seizures, headaches, or may be asymptomatic…
View article: Prone Transpsoas Approach for Adjacent Segment Disease and Flatback Deformity: Technical Note and Case Report
Prone Transpsoas Approach for Adjacent Segment Disease and Flatback Deformity: Technical Note and Case Report Open
The prone transpsoas approach is a relatively new technique to correct segmental kyphosis and global sagittal imbalance in a minimally invasive fashion. Here, we provide a detailed case report using the prone transpsoas approach to address…
View article: 17 Computational modelling of fractional flow reserve from coronary angiography: expert training required
17 Computational modelling of fractional flow reserve from coronary angiography: expert training required Open
Lal K, Gosling R, Priest J, Stephenson T, Lee T, Robinson N, O'Connor T, Gregory B, Son S, Hodgson A, Dunnill J, Lawford P, Hose R, Morris PD, Gunn J Sheffield Teaching Hospitals NHS Foundation Trust and Department of Infection, Immunity …