Pao‐Tien Chuang
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View article: Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs
Hippo signaling differentially regulates distal progenitor subpopulations and their transitional states to construct the mammalian lungs Open
Lung size control and cell type specification are key unresolved issues. In this study, we have engineered mosaic patterns of Hippo signaling to reveal the developmental potential of SOX9 + progenitors at the distal lung buds. Our results …
View article: Lung patterning: Is a distal‐to‐proximal gradient of cell allocation and fate decision a general paradigm?
Lung patterning: Is a distal‐to‐proximal gradient of cell allocation and fate decision a general paradigm? Open
Recent studies support a model in which the progeny of SOX9 + epithelial progenitors at the distal tip of lung branches undergo cell allocation and differentiation sequentially along the distal‐to‐proximal axis. Concomitant with the elonga…
View article: mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity
mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity Open
View article: Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions
Wnt5a–Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions Open
Lung branching morphogenesis requires reciprocal interactions between the epithelium and mesenchyme. How the lung branches are generated at a defined location and projected toward a specific direction remains a major unresolved issue. In t…
View article: A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange
A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange Open
View article: Author response: Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria
Author response: Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstrac…
View article: Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria
Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria Open
Alveolar formation requires coordinated movement and interaction between alveolar epithelial cells, mesenchymal myofibroblasts and endothelial cells/pericytes to produce secondary septa. These processes rely on the acquisition of distinct …
View article: A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis
A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis Open
Alveolar formation increases the surface area for gas-exchange and is key to the physiological function of the lung. Alveolar epithelial cells, myofibroblasts and endothelial cells undergo coordinated morphogenesis to generate epithelial f…
View article: Author response: A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis
Author response: A mammalian Wnt5a–Ror2–Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Alveolar formation increases …
View article: Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury
Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury Open
Production of an appropriate number of distinct cell types in precise locations during embryonic development is critical for proper tissue function. Homeostatic renewal or repair of damaged tissues in adults also requires cell expansion an…
View article: YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis
YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis Open
Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching…
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Author Index Open
View article: Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma
Selective Ablation of Tumor Suppressors in Parafollicular C Cells Elicits Medullary Thyroid Carcinoma Open
Among the four different types of thyroid cancer, treatment of medullary thyroid carcinoma poses a major challenge because of its propensity of early metastasis. To further investigate the molecular mechanisms of medullary thyroid carcinom…
View article: Author response: YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis
Author response: YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Branching morp…