T Poch
YOU?
Author Swipe
View article: An immunobiliary single-cell atlas resolves crosstalk of type 2 cDCs and γδT cells in cholangitis
An immunobiliary single-cell atlas resolves crosstalk of type 2 cDCs and γδT cells in cholangitis Open
Background and aims The immunobiliary niche serves as a reservoir of tissue-resident immune cells, yet the role of unconventional T cells during cholangitis remains poorly understood. Here, we connect cell state dynamics of type 2 conventi…
View article: Testosterone affects female CD4+ T cells in healthy individuals and autoimmune liver diseases
Testosterone affects female CD4+ T cells in healthy individuals and autoimmune liver diseases Open
Autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC) are autoimmune liver diseases with strong female predominance. They are caused by T cell-mediated injury of hepatic parenchymal cells, but the mechanisms underlying this sex …
View article: Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
Intergenic risk variant rs56258221 skews the fate of naive CD4+ T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis Open
Primary sclerosing cholangitis (PSC) is an immune-mediated liver disease of unknown pathogenesis, with a high risk to develop cirrhosis and malignancies. Functional dysregulation of T cells and association with genetic polymorphisms in T c…
View article: <i>HLA-DPA1*02:01~B1*01:01</i> is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells
<i>HLA-DPA1*02:01~B1*01:01</i> is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells Open
Objective Primary sclerosing cholangitis (PSC) is characterised by bile duct strictures and progressive liver disease, eventually requiring liver transplantation. Although the pathogenesis of PSC remains incompletely understood, strong ass…
View article: The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells
The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells Open
The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity. The co-inhibitory receptor TIGIT decreases NK cell cytotoxicity and is involve…
View article: Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver
Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver Open
The liver is an immune-privileged organ that can deactivate autoreactive T cells. Yet in autoimmune hepatitis (AIH), autoreactive T cells can defy hepatic control and attack the liver. To elucidate how tolerance to self-antigens is lost du…
View article: Monocytes as Potential Mediators of Pathogen‐Induced T‐Helper 17 Differentiation in Patients With Primary Sclerosing Cholangitis (PSC)
Monocytes as Potential Mediators of Pathogen‐Induced T‐Helper 17 Differentiation in Patients With Primary Sclerosing Cholangitis (PSC) Open
Background and Aims T cells from patients with primary sclerosing cholangitis (PSC) show a prominent interleukin (IL)‐17 response upon stimulation with bacteria or fungi, yet the reasons for this dominant T‐helper 17 (Th17) response in PSC…
View article: The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver‐Homing Receptors on Human Blood CD56bright Natural Killer Cells
The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver‐Homing Receptors on Human Blood CD56bright Natural Killer Cells Open
The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver‐resident NK cells in mice. In human NK cells, the role of PLZ…
View article: CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans
CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans Open
Macrophages play central roles in inflammatory reactions and initiation of immune responses during infections. More than 80% of total tissue macrophages are described to be located in the liver as liver-resident macrophages, also named Kup…
View article: CCL21‐expression and accumulation of CCR7 <sup>+</sup> NK cells in livers of patients with primary sclerosing cholangitis
CCL21‐expression and accumulation of CCR7 <sup>+</sup> NK cells in livers of patients with primary sclerosing cholangitis Open
The pathogenesis of primary sclerosing cholangitis (PSC), an autoimmune liver disease, remains unknown. The aim of this study was to characterize peripheral blood and intrahepatic NK cells from patients with PSC. Peripheral blood samples f…
View article: Human liver-derived CXCR6+ NK cells are predominantly educated through NKG2A and show reduced cytokine production
Human liver-derived CXCR6+ NK cells are predominantly educated through NKG2A and show reduced cytokine production Open
NK cells have been implicated to affect the outcome of numerous liver diseases. In particular, members of the killer-cell Ig-like receptor (KIR) family, predominantly expressed by NK cells, have been associated with the outcome of hepatiti…
View article: Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71
Tissue-resident NK cells differ in their expression profile of the nutrient transporters Glut1, CD98 and CD71 Open
Metabolism is a critical basis for immune cell functionality. It was recently shown that NK cell subsets from peripheral blood modulate their expression of nutrient receptors following cytokine stimulation, demonstrating that NK cells can …
View article: Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells
Mechanistic peculiarities of activation-induced mobilization of cytotoxic effector proteins in human T cells Open
It is widely accepted that cytotoxic T and NK cells store effector proteins including granzymes, perforin and Fas ligand (FasL) in intracellular granules, often referred to as secretory lysosomes. Upon target cell encounter, these organell…
View article: Proliferative capacity exhibited by human liver-resident CD49a+CD25+ NK cells
Proliferative capacity exhibited by human liver-resident CD49a+CD25+ NK cells Open
The recruitment and retention of Natural Killer (NK) cells in the liver are thought to play an important role during hepatotropic infections and liver cirrhosis. The aims of this study were to determine differences between liver-derived an…