Explanipedia

Comprehensive molecular landscape of anal squamous cell carcinoma: analysis of tissue and liquid biopsies from 1844 patients Open

Cristina Smolenschi, Saumya D. Sisoudiya, Victor Euzen, Mihaela Aldea, A. Tarabay , et al. · 2025

Anal squamous cell carcinoma (aSCC) is a rare, predominantly HPV-driven cancer with limited treatment options. This study aimed to define its genomic landscape, identify actionable targets (AT), and highlight the clinical value of molecula…

Heads or tails? In-depth analysis of pancreatic cancer outcome according to tumor location Open

A. Fernandes, Aurélien Lambert, A. Tarabay, Antoine Hollebecque, C. Smolenschi , et al. · 2025

Identifying health conditions associated with an increased risk of pancreatic ductal adenocarcinoma at medium term in nationwide electronic health records of primary care physicians Open

Elie Rassy, Suzette Delaloge, Yannis Slaouti, T. Pudlarz, Béranger Lekens , et al. · 2025

Young-onset biliary tract cancers: Characteristics, treatment patterns, and patient outcomes Open

T. Pudlarz, T. Anthony, Shaposhnikova Natalia, Marc Hilmi, Leony Antoun , et al. · 2025

75P Clinical and molecular characteristics of young onset colorectal cancers Open

Elie Akoury, Cristina Smolenschi, N. Masri, Antoine Hollebecque, Valérie Boige , et al. · 2025

292P Long survival in metastatic pancreatic cancer: Clinical and biological predictors from a large retrospective cohort Open

A. Tarabay, Aurélien Lambert, Antoine Hollebecque, Cristina Smolenschi, Alina Fuerea , et al. · 2025

304P Impact of neoadjuvant and adjuvant strategies on outcomes in non-metastatic pancreatic cancer Open

S. Blanchet-Deverly, M. Debiais, Alexandre Megherbi, Antoine Hollebecque, Géraldine M. Camilleri , et al. · 2025

48P Impact of the KRAS mutation subtype on treatment response in metastatic colorectal cancer Open

N. Masri, M-L. Tanguy, E.J. El Rawadi, Valérie Boige, Adina Ioana Mihele , et al. · 2025

Intra-arterial hepatic chemotherapy in metastatic colorectal cancer: differences between oxaliplatin-naive versus oxaliplatin-pretreated patients Open

E Rawadi, Baptiste Bonnet, Luisa Pierotti, V. Boige, Lambros Tselikas , et al. · 2025

429P Early results of lung cancer screening in breast cancer survivors within the INTERCEPTION-LUNG program Open

P. Abdayem, T. Ben Ahmed, T. Pudlarz, Lucie Véron, H.N. Caron , et al. · 2025

Heads or Tails? In-Depth Analysis of Pancreatic Cancer Outcome According to Tumor Location Open

Aristi P. Fernandes, Aurélien Lambert, Anthony Tarabay, Antoine Hollebecque, Cristina Smolenschi , et al. · 2025

KRAS, a New Target for Precision Medicine in Colorectal Cancer? Open

Alice Boilève, Cristina Smolenschi, Aurélien Lambert, Valérie Boige, Matthieu Delaye , et al. · 2024

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with significant public health concerns. This review examines the landscape of KRAS inhibition in colorectal cancer (CRC), focusing on recent advances in…

Professionals' Perceptions of the Colorectal Cancer Pathway: Results of a Co‐Constructed Qualitative Study Open

Matthieu Delaye, Alice Poloméni, Sylvie Faiderbe, Nadège Berlioz, Chaïma Benssekoum , et al. · 2024

Introduction Qualitative research on the perceptions of healthcare professionals involved in cancer care about their respective roles in the patient care pathway is limited. Therefore, the aim of this qualitative study was to document thes…

Role of molecular biology in the management of pancreatic cancer Open

Alice Boilève, Cristina Smolenschi, Aurélien Lambert, Valérie Boige, Anthony Tarabay , et al. · 2024

Pancreatic ductal adenocarcinoma (PDAC) presents significant challenges in patient management due to a dismal prognosis, increasing incidence, and limited treatment options. In this regard, precision medicine, which personalizes treatments…

Case report: Microsatellite instability determination is not always black and white in Lynch syndrome diagnosis Open

Julieta Rodriguez, Damien Vasseur, Mohamed‐Amine Bani, Odile Cabaret, Sophie Cotteret , et al. · 2024

Introduction Microsatellite instability (MSI) is a genetic marker that is useful in the detection and treatment of Lynch syndrome (Sd). Although conventional techniques such as immunohistochemistry (IHC) and polymerase chain reaction (PCR)…

Pancreatic adenocarcinoma third line systemic treatments: a retrospective cohort study Open

Anna Gueiderikh, A. Tarabay, M. Abdelouahab, Cristina Smolenschi, M-L. Tanguy , et al. · 2024

Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care Open

Benoı̂t Blanchet, Alexandre Xu-Vuilard, Anne Jouinot, Florent Puisset, David Combarel , et al. · 2024

Codon-specific KRAS mutations predict survival in advanced pancreatic cancer Open

Alice Boilève, Adrien Rousseau, Marc Hilmi, A. Tarabay, Jacques R.R. Mathieu , et al. · 2024

Background: How distinct KRAS alterations in pancreatic adenocarcinoma (PDAC) influence tumor initiation and outcomes remains unclear. Moreover, KRAS is now partly targetable with novel specific inhibitors targeting KRASG12 (G12C or G12D),…

1667P Clinical and molecular features of young onset pancreatic adenocarcinoma Open

Marc Rémond, A. Tarabay, Antoine Hollebecque, Maximiliano Gelli, Ali Mouawia , et al. · 2023

112P Clinical, genomic and transcriptomic characteristics of young-onset biliary tract cancers Open

T. Pudlarz, Lina Antoun, Antoine Rousseau, R. Nicolle, Maximiliano Gelli , et al. · 2023

Targetable Molecular Alterations in the Treatment of Biliary Tract Cancers: An Overview of the Available Treatments Open

Marine Valéry, Damien Vasseur, Francesco Fachinetti, Alice Boilève, Cristina Smolenschi , et al. · 2023

Biliary tract cancers (BTCs) are rare tumours, most often diagnosed at an unresectable stage, associated with poor prognosis, with a 5-year survival rate not exceeding 10%. Only first- and second-line treatments are well codified with the …

P-340 Bidirectional chemotherapy for patients with gastrointestinal peritoneal carcinomatosis Open

Cristina Smolenschi, Antoine Hollebecque, Marine Valéry, Alice Boilève, Lina Antoun , et al. · 2023

172P Early impact of a personalised cancer interception programme for women at non-genetic high risk of breast cancer (BC) Open

Lucie Véron, M. Aupomerol, Kaïssa Ouali, T. Pudlarz, Léna Degousée , et al. · 2023

Risk-based cancer prevention is a major future strategy. "Interception" is a French pilot, mixed community-hospital and digital-physical programme based on 4 pillars: 1. community-based identification of people at high risk of cancer; 2. a…

Neoadjuvant Nivolumab Plus Ipilimumab and Adjuvant Nivolumab in Localized Deficient Mismatch Repair/Microsatellite Instability–High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase II Study Open

Thierry André, David Tougeron, Guillaume Piessen, Christelle de la Fouchardière, Christophe Louvet , et al. · 2022

PURPOSE In patients with resectable gastric/gastroesophageal junction (GEJ) adenocarcinoma, surgery plus perioperative platinum-based chemotherapy is the standard of care. Perioperative chemotherapy remains debatable for gastric/GEJ adenoc…

Treatments after Immune Checkpoint Inhibitors in Patients with dMMR/MSI Metastatic Colorectal Cancer Open

Quang Loc Bui, Léo Mas, Antoine Hollebecque, David Tougeron, Christelle de la Fouchardière , et al. · 2022

Background: Several studies reported improved outcomes with conventional treatments (CT, i.e., chemotherapy ± targeted therapy) administered after immune checkpoints inhibitors (ICI) in certain tumor types. No data are available concerning…

Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency Open

Romain Cohen, Raphaël Colle, T. Pudlarz, Maximilien Heran, Alex Duval , et al. · 2021

Microsatellite instability (MSI) is a tumor phenotype related to a deficient DNA mismatch repair system (dMMR). This phenotype, observed in 5% of metastatic mCRC but 10–18% of localized CRC, is associated with high tumor mutational burden …

46P [18F]2-Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18FDG-PET/CT) in patients treated with immune checkpoint inhibitors (ICI) for microsatellite instability-high metastatic colorectal cancer (MSI mCRC) Open

T. Pudlarz, Françoise Montravers, M-L. Garcia-Larnicol, Emmanuelle Kempf, Jaafar Bennouna , et al. · 2020

Molecular Targets for the Treatment of Metastatic Colorectal Cancer Open

Romain Cohen, T. Pudlarz, Jean-François Delattre, Raphaël Colle, Thierry André · 2020

Over the past years, colorectal cancer (CRC) was subtyped according to its molecular and genetic characteristics, allowing the development of therapeutic strategies, based on predictive biomarkers. Biomarkers such as microsatellite instabi…

Patients atteints d’un cancer gastrique localisé MSI/dMMR, pas de chimiothérapie mais une immunothérapie périopératoire : l’essai de phase II GERCOR NEONIPIGA vient d’être ouvert au recrutement Open

Romain Cohen, T. Pudlarz, Marie‐Line Garcia‐Larnicol, Déwi Vernerey, Xavier Dray , et al. · 2020

Traitement des cancers colorectaux par immunothérapie : aller au-delà de MSI avec la classification moléculaire (CMS) et la charge mutationnelle Open

Romain Cohen, Maximilien Heran, T. Pudlarz, Marc Hilmi, Christophe Tournigand , et al. · 2019

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