Timothy P. L. Roberts
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View article: BIOM-87. SODIUM (23NA) MRI AND CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING IN TYPICALLY DEVELOPING CHILDREN AND IN PEDIATRIC BRAIN TUMORS
BIOM-87. SODIUM (23NA) MRI AND CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING IN TYPICALLY DEVELOPING CHILDREN AND IN PEDIATRIC BRAIN TUMORS Open
In contrast to conventional 1H MRI, which primarily reveals water molecule distribution, with only indirect association with the physico-chemical microenvironment, 23Na (sodium) MRI and chemical exchange saturation transfer (CEST) have a m…
View article: Editorial: Magnetic neurophysiology: the cutting edge of real time neurodiagnostic technology
Editorial: Magnetic neurophysiology: the cutting edge of real time neurodiagnostic technology Open
View article: Big Data, Small Bias: Harmonizing Diffusion <scp>MRI</scp> ‐Based Structural Connectomes to Mitigate Site‐Related Bias in Data Integration
Big Data, Small Bias: Harmonizing Diffusion <span>MRI</span> ‐Based Structural Connectomes to Mitigate Site‐Related Bias in Data Integration Open
Diffusion MRI‐based structural connectomes are increasingly used to investigate brain connectivity changes associated with various disorders. However, small sample sizes in individual studies, along with highly heterogeneous disorder‐relat…
View article: Auditory evoked neuromagnetic response latency is associated with language ability in preschoolers with an elevated likelihood of intellectual or developmental disability
Auditory evoked neuromagnetic response latency is associated with language ability in preschoolers with an elevated likelihood of intellectual or developmental disability Open
Introduction We have shown that a delayed auditory cortex neural response is associated with language ability in school-age children with autism spectrum disorder and related syndromes, with this delay exacerbated in the context of co-occu…
View article: Correction: A natural history study to track brain and spinal cord changes in individuals with Friedreich’s ataxia: TRACK-FA study protocol
Correction: A natural history study to track brain and spinal cord changes in individuals with Friedreich’s ataxia: TRACK-FA study protocol Open
[This corrects the article DOI: 10.1371/journal.pone.0269649.].
View article: The Tairawhiti Heart Function Accelerated Titration Clinic Early Experience
The Tairawhiti Heart Function Accelerated Titration Clinic Early Experience Open
View article: Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the <scp>TRACK</scp>‐<scp>FA</scp> Study
Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the <span>TRACK</span>‐<span>FA</span> Study Open
Objective We aimed to quantify differences in the brain and spinal cord between Friedreich ataxia and controls, stratified by age and disease stage, including for the first time in young children. Methods TRACK‐FA is the largest prospectiv…
View article: Correction: A natural history study to track brain and spinal cord changes in individuals with Friedreich’s ataxia: TRACK-FA study protocol
Correction: A natural history study to track brain and spinal cord changes in individuals with Friedreich’s ataxia: TRACK-FA study protocol Open
[This corrects the article DOI: 10.1371/journal.pone.0269649.].
View article: Regionally specific resting-state beta neural power predicts brain injury and symptom recovery in adolescents with concussion: a longitudinal study
Regionally specific resting-state beta neural power predicts brain injury and symptom recovery in adolescents with concussion: a longitudinal study Open
Mild traumatic brain injury (mTBI) is common in adolescents. Magnetoencephalography (MEG) studies (primarily reporting on adult males) have demonstrated abnormal resting-state (RS) brain activity in mTBI. The present study sought to identi…
View article: Beyond sensitivity: what are the enabling opportunities of OPM-MEG?
Beyond sensitivity: what are the enabling opportunities of OPM-MEG? Open
While optically-pumped magnetometer (OPM) technology offers a number of compelling advantages over its SQUID predecessor for magnetoencephalography (MEG), many studies and viewpoints focus on issues of (i) scalp placement, with commensurat…
View article: Sodium MRI in Pediatric Brain Tumors
Sodium MRI in Pediatric Brain Tumors Open
Direct sodium MRI (23Na-MRI) derives its signal from spin-manipulation of the 23Na nucleus itself and not the more conventional and familiar 1H-MRI. Although present at much lower concentrations in the huma…
View article: Delta Wave MRI: fMRI of Electrophysiologic Activity
Delta Wave MRI: fMRI of Electrophysiologic Activity Open
We propose a novel application of MR encephalography (MREG) to detect the frequency spectrum of endogenous slow oscillatory brain activity (delta, <4 Hz). MREG offers faster image acquisition than conventional fMRI and superior spatial loc…
View article: <scp>GABA</scp> and glutamate measurements in temporal cortex of autistic children
<span>GABA</span> and glutamate measurements in temporal cortex of autistic children Open
Autism spectrum disorder (ASD) is a neurodevelopmental disorder and presents with challenges in social communication. A hypothesized underlying contributing mechanism is the imbalance in excitation and inhibition (E/I), partly influenced b…
View article: Big Data, Small Bias: Harmonizing Diffusion MRI-Based Structural Connectomes to Mitigate Site-Related Bias in Data Integration
Big Data, Small Bias: Harmonizing Diffusion MRI-Based Structural Connectomes to Mitigate Site-Related Bias in Data Integration Open
Diffusion MRI-based structural connectomes are increasingly used to investigate brain connectivity changes associated with various disorders. However, small sample sizes in individual studies, along with highly heterogeneous disorder-relat…
View article: The development and structure of the HEALthy Brain and Child Development (HBCD) Study EEG protocol
The development and structure of the HEALthy Brain and Child Development (HBCD) Study EEG protocol Open
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early chi…
View article: Functional and structural maturation of auditory cortex from 2 months to 2 years old
Functional and structural maturation of auditory cortex from 2 months to 2 years old Open
View article: Arterial Spin-Labeling Perfusion Lightbulb Sign: An Imaging Biomarker of Pediatric Posterior Fossa Hemangioblastoma
Arterial Spin-Labeling Perfusion Lightbulb Sign: An Imaging Biomarker of Pediatric Posterior Fossa Hemangioblastoma Open
Lightbulb-like intense and homogeneous hyperperfusion patterns on ASL are helpful in diagnosing posterior fossa hemangioblastoma in children.
View article: Automated Dentate Nucleus Segmentation from QSM Images Using Deep Learning
Automated Dentate Nucleus Segmentation from QSM Images Using Deep Learning Open
Purpose To develop a dentate nucleus (DN) segmentation tool using deep learning (DL) applied to brain quantitative susceptibility mapping (QSM) images. Materials and Methods Brain QSM images from 132 healthy controls and 170 individuals wi…
View article: Functional and structural maturation of auditory cortex from 2 months to 2 years old
Functional and structural maturation of auditory cortex from 2 months to 2 years old Open
In school-age children, the myelination of the auditory radiation thalamocortical pathway is associated with the latency of auditory evoked responses, with the myelination of thalamocortical axons facilitating the rapid propagation of acou…
View article: <scp>Electroencephalographic</scp> Correlates of Clinical Severity in the Natural history study of RTT and Related Disorders
<span>Electroencephalographic</span> Correlates of Clinical Severity in the Natural history study of RTT and Related Disorders Open
Objective This study was undertaken to characterize quantitative electroencephalographic (EEG) features in participants from the Natural history study of RTT and Related Disorders and to assess the potential for these features to act as ob…
View article: Functional and Structural Maturation of Auditory Cortex from 2 Months to 2 Years Old
Functional and Structural Maturation of Auditory Cortex from 2 Months to 2 Years Old Open
View article: Glutamate measurements using edited MRS
Glutamate measurements using edited MRS Open
Purpose To demonstrate J‐ difference coediting of glutamate using Hadamard encoding and reconstruction of Mescher‐Garwood‐edited spectroscopy (HERMES). Methods Density‐matrix simulations of HERMES (TE 80 ms) and 1D J ‐resolved (TE 31–229 m…
View article: Brain Growth Charts for Quantitative Analysis of Pediatric Clinical Brain MRI Scans with Limited Imaging Pathology
Brain Growth Charts for Quantitative Analysis of Pediatric Clinical Brain MRI Scans with Limited Imaging Pathology Open
Background Clinically acquired brain MRI scans represent a valuable but underused resource for investigating neurodevelopment due to their technical heterogeneity and lack of appropriate controls. These barriers have curtailed retrospectiv…
View article: Maturation of auditory cortex neural responses during infancy and toddlerhood
Maturation of auditory cortex neural responses during infancy and toddlerhood Open
The infant auditory system rapidly matures across the first years of life, with a primary goal of obtaining ever-more-accurate real-time representations of the external world. Our understanding of how left and right auditory cortex neural …
View article: Contributions to auditory system conduction velocity: insights with multi-modal neuroimaging and machine learning in children with ASD and XYY syndrome
Contributions to auditory system conduction velocity: insights with multi-modal neuroimaging and machine learning in children with ASD and XYY syndrome Open
Introduction The M50 electrophysiological auditory evoked response time can be measured at the superior temporal gyrus with magnetoencephalography (MEG) and its latency is related to the conduction velocity of auditory input passing from e…
View article: Imaging fibrosis in pediatric kidney transplantation: A pilot study
Imaging fibrosis in pediatric kidney transplantation: A pilot study Open
Background Noninvasive alternatives to biopsy for assessment of interstitial fibrosis and tubular atrophy (IFTA), the major determinant of kidney transplant failure, remain profoundly limited. Elastography is a noninvasive technique that p…
View article: Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events
Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events Open
About 30% of patients who have a kidney transplant with underlying nephrotic syndrome (NS) experience rapid relapse of disease in their new graft. This is speculated to be due to a host-derived circulating factor acting on podocytes, the t…
View article: A comparison of resting‐state eyes‐closed and dark‐room alpha‐band activity in children
A comparison of resting‐state eyes‐closed and dark‐room alpha‐band activity in children Open
In a relaxed and awake state with the eyes closed, 8–12 Hz neural oscillations are the dominant rhythm, most prominent in parietal‐occipital regions. Resting‐state (RS) alpha is associated with processing speed and is also thought to be ce…
View article: Comparison of evoked potentials across four related developmental encephalopathies
Comparison of evoked potentials across four related developmental encephalopathies Open
Background Developing biomarkers is a priority for drug development for all conditions, but vital in the rare neurodevelopmental disorders where sensitive outcome measures are lacking. We have previously demonstrated the feasibility and tr…
View article: Somatosensory and motor representations following bilateral transplants of the hands: A 6-year longitudinal case report on the first pediatric bilateral hand transplant patient
Somatosensory and motor representations following bilateral transplants of the hands: A 6-year longitudinal case report on the first pediatric bilateral hand transplant patient Open
A vascularized composite tissue allotransplantation (VCA) was performed at the Children's Hospital of Philadelphia (CHOP), on an 8-year-old patient in 2015, six years after bilateral hand and foot amputation. Hand VCA resulted in reafferen…