T Bamba
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View article: Prediction of Effects of Steroid Therapy for Severe Ulcerative Colitis. Efficacy of Colonoscopy.
Prediction of Effects of Steroid Therapy for Severe Ulcerative Colitis. Efficacy of Colonoscopy. Open
重症潰瘍性大腸炎ではステロイド強力静注療法や白血球・顆粒球除去療法などの内科的治療が行われるが, 無効例では手術を余儀なくされる. 今回, 重症潰瘍性大腸炎に対するステロイド強力静注療法の効果に関与する因子について検討した. 当科にて加療した潰瘍性大腸炎170例中, 重症は59例で, このうちプレドニゾロン (PSL) 強力静注療法を施行し7～10日目に有効性を評価できた35例の成績は, 有効19例, 無効16例であった. これら35例について内視鏡所見, Seo's co…
View article: A case of toxic shock‐like syndrome presenting with serious hypoproteinaemia because of a protein‐losing gastroenteropathy
A case of toxic shock‐like syndrome presenting with serious hypoproteinaemia because of a protein‐losing gastroenteropathy Open
Tasaki K, Sasaki M, Bamba M, Shintani Y, Andoh A, Tsujikawa T, Koyama S, Fujiyama Y, Bamba T (Shiga University of Medical Science, Shiga, Japan). A case of toxic shock‐like syndrome presenting with serious hypoproteinaemia because of a pro…
View article: Cooperation of interleukin-17 and interferon-<i>γ</i>on chemokine secretion in human fetal intestinal epithelial cells
Cooperation of interleukin-17 and interferon-<i>γ</i>on chemokine secretion in human fetal intestinal epithelial cells Open
Summary Interleukin (IL)-17 is a newly identified T cell-derived cytokine that can regulate the functions of a variety of cell types. In this study, we investigated the effects of IL-17 and interferon (IFN)-γ on chemokine secretion in huma…
View article: Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes
Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes Open
SUMMARY Dendritic cells (DCs) have been regarded as one of the effective antigen-presenting cells, but the relationship between DCs and lymphocytes, in particular natural killer (NK) cells, remains unclear. In this study, we evaluated how …
View article: Prevention of murine acute graft-<i>versus</i>-host disease by staphylococcalenterotoxin B treatment
Prevention of murine acute graft-<i>versus</i>-host disease by staphylococcalenterotoxin B treatment Open
SUMMARY Retroviral superantigens such as minor lymphocyte stimulating (Mls) antigen play an important role in the pathogenesis of acute graft-versus-host disease (GVHD). However, it remains unclear how exogenous bacterial superantigens mod…
View article: Development of dextran sulphate sodium-induced experimental colitis is suppressed in genetically mast cell-deficient <i>Ws/Ws</i> rats
Development of dextran sulphate sodium-induced experimental colitis is suppressed in genetically mast cell-deficient <i>Ws/Ws</i> rats Open
SUMMARY Ws/Ws rats have a small deletion of the c-kit gene, and are deficient in both mucosal-type mast cells (MMC) and connective tissue-type mast cells (CTMC). In the present study we investigated the role of intestinal MMC in the develo…
View article: Counter-regulatory effect of sodium butyrate on tumour necrosis factor-alpha (TNF-α)-induced complement C3 and factor B biosynthesis in human intestinal epithelial cells
Counter-regulatory effect of sodium butyrate on tumour necrosis factor-alpha (TNF-α)-induced complement C3 and factor B biosynthesis in human intestinal epithelial cells Open
SUMMARY The various biological activities of butyrate have been well documented. In this study, we tested the effects of butyrate on TNF-α-induced complement C3 and factor B biosynthesis in human intestinal epithelial cells. The biosynthes…
View article: Sodium butyrate blocks interferon-gamma (IFN-γ)-induced biosynthesis of MHC class III gene products (complement C4 and factor B) in human fetal intestinal epithelial cells
Sodium butyrate blocks interferon-gamma (IFN-γ)-induced biosynthesis of MHC class III gene products (complement C4 and factor B) in human fetal intestinal epithelial cells Open
SUMMARY Human intestinal epithelial cells have been established as local sites for complement biosynthesis. In this study, we investigated the effects of IFN-γ and sodium butyrate on biosynthesis of MHC class III gene products (complement …
View article: Rapid intestinal ischaemia-reperfusion injury is suppressed in genetically mast cell-deficient <i>Ws/Ws</i> rats
Rapid intestinal ischaemia-reperfusion injury is suppressed in genetically mast cell-deficient <i>Ws/Ws</i> rats Open
SUMMARY Ws/Ws rats have a small deletion of the c-kit gene, and are deficient in both mucosal and connective tissue-type mast cells. In this study, the role of mucosal type mast cells (MMC) in the development of intestinal ischaemia-reperf…
View article: In situ expression of complement C3 and factor B genes in normal colorectal mucosa, adenomas and carcinomas
In situ expression of complement C3 and factor B genes in normal colorectal mucosa, adenomas and carcinomas Open
View article: Detection of complement C3 and factor B gene expression in normal colorectal mucosa, adenomas and carcinomas
Detection of complement C3 and factor B gene expression in normal colorectal mucosa, adenomas and carcinomas Open
SUMMARY Local secretion of complement components in the human intestine has been previously reported. However, the cellular source has not been identified. In this study, we demonstrate complement C3 and factor B mRNA expression in the nor…
View article: A blockade of complement activation prevents rapid intestinal ischaemia-reperfusion injury by modulating mucosal mast cell degranulation in rats
A blockade of complement activation prevents rapid intestinal ischaemia-reperfusion injury by modulating mucosal mast cell degranulation in rats Open
SUMMARY We attempted to define the putative role of complement activation in association with mucosal mast cell (MMC) degranulation in the pathogenesis of rapid intestinal ischaemia-reperfusion (I/R) injury. We prepared complement activity…
View article: Local secretion of complement C3 in the exocrine pancreas: Ductal epithelial cells as a possible biosynthetic site
Local secretion of complement C3 in the exocrine pancreas: Ductal epithelial cells as a possible biosynthetic site Open
View article: Biological Properties of the Colony-Promoting Activity in Extracts Prepared from Murine Kidney
Biological Properties of the Colony-Promoting Activity in Extracts Prepared from Murine Kidney Open
Aqueous extracts prepared from the murine kidney (MKE) promoted colony formation derived from murine hematopoietic progenitor cells in serum-free cultures stimulated by interleukin-3 (IL-3) and erythropoietin (Epo). MKE itself did not stim…
View article: Macrophage inflammatory protein-1α/stem cell inhibitor like immuno-reactivity in the enteric nervous system, and its possible role in mucosal immunemodulation and epithelial repair
Macrophage inflammatory protein-1α/stem cell inhibitor like immuno-reactivity in the enteric nervous system, and its possible role in mucosal immunemodulation and epithelial repair Open
View article: IL-4 is a potent inducer of decay-accelerating factor (DAF;CD55) expression on intestinal epithelial cells
IL-4 is a potent inducer of decay-accelerating factor (DAF;CD55) expression on intestinal epithelial cells Open
Porcine membrane cofactor protein (pMCP), a complement regulatory protein, is widely expressed in various tissues. Particularly, it is highly expressed on vascular endothelium. The objective of this study was to investigate whether the pMC…
View article: TNF-α, IFN-γ, and Il-4 differentially regulate complement production in human intestinal epithelial cell line, HT-29
TNF-α, IFN-γ, and Il-4 differentially regulate complement production in human intestinal epithelial cell line, HT-29 Open
Afferent projections to the preoptic area and hypothalamus were studied in the rat by using horseradish peroxidase as a retrograde tracer. Microiontophoretic injections were made stereotaxically into one of six regions: medial preoptic are…
View article: Differential cytokine regulation of complement C3, C4, and factor B synthesis in human intestinal epithelial cell line, Caco-2.
Differential cytokine regulation of complement C3, C4, and factor B synthesis in human intestinal epithelial cell line, Caco-2. Open
In the intestinal tract, the local synthesis of C3 and components of both the classical (C4) and alternative (factor B) C activation pathway has previously been demonstrated in vivo. However, the cellular source of this local C synthesis h…
View article: A novel IgA protease from <i>Clostridium sp.</i> capable of cleaving IgA1 and IgA2 A2m(1) but not IgA2 A2m(2) allotype paraproteins.
A novel IgA protease from <i>Clostridium sp.</i> capable of cleaving IgA1 and IgA2 A2m(1) but not IgA2 A2m(2) allotype paraproteins. Open
Three bacterial strains of Bifidobacterium and Clostridium sp. from patients with inflammatory bowel disease (I.B.D.) and Streptococcus pneumoniae from a patient with pneumonia were identified to produce extracellular proteases cleaving Ig…