Jes Olesen
YOU?
Author Swipe
View article: Dim Flicker: An Endogenous Visual Percept and Its Disease Associations
Dim Flicker: An Endogenous Visual Percept and Its Disease Associations Open
Background/Objectives: Visual sensations from ocular structures are entoptic. They may include retinal vascular shadows, perifoveal leukocyte migration, and phosphenes during eye movement causing retinal deformation. Abnormal neural activi…
View article: Cohort profile and representativeness of participants in the Danish monozygotic twin study on migraine
Cohort profile and representativeness of participants in the Danish monozygotic twin study on migraine Open
The Danish Monozygotic Twin Study on Migraine is a population-based twin study established in 2023–2024. The cohort was created to lay the foundation for innovative studies of the role of environmental, genetic, and epigenetic factors and …
View article: Migraine-like headache attributed to a causative disorder: primary migraine or secondary headache with a migraine-like phenotype?
Migraine-like headache attributed to a causative disorder: primary migraine or secondary headache with a migraine-like phenotype? Open
View article: Research to improve headache classification: Results, methods, and future challenges
Research to improve headache classification: Results, methods, and future challenges Open
Introduction The international headache classification has been enormously important promoting research and clinical management of patients with headache. It is a living document that develops from edition to edition and changes have been …
View article: <i>De novo</i> nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headache disorders
<i>De novo</i> nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headache disorders Open
ATP-sensitive potassium (K ATP ) channel opener levcromakalim is a potent inducer of vasodilation, headache, and migraine attacks in humans and tactile hypersensitivity in mice. Other migraine-inducing agents such as nitric oxide (NO) dono…
View article: Genome sequencing reveals the <i>Adgrl3</i> ( <i>ADGRL3</i> ) gene as a possible cause of cephalic hypersensitivity in the STA rat and migraine in humans
Genome sequencing reveals the <i>Adgrl3</i> ( <i>ADGRL3</i> ) gene as a possible cause of cephalic hypersensitivity in the STA rat and migraine in humans Open
Background Migraine is a common primary headache disorder with a significant genetic component influencing its pathophysiology, in which the trigeminal system plays a central role. The spontaneous trigeminal allodynia (STA) inbred rat stra…
View article: Diagnosing migraine from genome-wide genotype data: a machine learning analysis
Diagnosing migraine from genome-wide genotype data: a machine learning analysis Open
Migraine has an assumed polygenic basis, but the genetic risk variants identified in genome-wide association studies only explain a proportion of the heritability. We aimed to develop machine learning models, capturing non-additive and int…
View article: Transient focal neurological symptoms and headache: is it TIA or migraine with aura?
Transient focal neurological symptoms and headache: is it TIA or migraine with aura? Open
View article: Development and evaluation of a new semi-quantitative and morphometric scoring system for magnetic resonance imaging in adolescents with Osgood Schlatter Disease (The OSIS Score)
Development and evaluation of a new semi-quantitative and morphometric scoring system for magnetic resonance imaging in adolescents with Osgood Schlatter Disease (The OSIS Score) Open
This semi-quantitative scoring system for MRI allows the comprehensive and reliable assessment of features relevant for evaluating affected tissues in adolescent patients with OSD.
View article: Cerebral blood flow and arterial responses in migraine: history and future perspectives
Cerebral blood flow and arterial responses in migraine: history and future perspectives Open
Introduction It is largely accepted that migraine with aura (MA) is caused by cortical spreading depression (CSD) and that migraine without aura (MO) is not. This is mostly based on old studies of regional cerebral blood flow (rCBF) and st…
View article: Field-testing the explicit diagnostic criteria for transient ischemic attack: a diagnostic accuracy study
Field-testing the explicit diagnostic criteria for transient ischemic attack: a diagnostic accuracy study Open
View article: Methodology of drug trials in migraine: History and suggestions for the future
Methodology of drug trials in migraine: History and suggestions for the future Open
There is a multitude of scientific papers and guideline papers on the methodology of drug trials in migraine. Here, we try to condense this into a single paper and to make proposals for future consideration. Literature known by the authors…
View article: No association between migraine and HLA alleles in a cohort of 13,210 individuals with migraine from the Danish Blood Donor Study
No association between migraine and HLA alleles in a cohort of 13,210 individuals with migraine from the Danish Blood Donor Study Open
Objective To determine the association between human leukocyte antigen (HLA) alleles and migraine, migraine subtypes, and sex‐specific factors. Background It has long been hypothesized that inflammation contributes to migraine pathophysiol…
View article: VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model
VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model Open
Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine attacks and a rece…
View article: Static autoregulation in humans
Static autoregulation in humans Open
A recent publication in JCBFM, “Static autoregulation in humans” gives rise to critical comments. Autoregulation of cerebral blood flow implies that flow is rather constant within a certain blood pressure (BP) range with a lower and an upp…
View article: VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model
VPAC1 and VPAC2 receptors mediate tactile hindpaw hypersensitivity and carotid artery dilatation induced by PACAP38 in a migraine relevant mouse model Open
Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine attacks and a rece…
View article: Provocation of attacks to discover migraine signaling mechanisms and new drug targets: early history and future perspectives - a narrative review
Provocation of attacks to discover migraine signaling mechanisms and new drug targets: early history and future perspectives - a narrative review Open
Introduction The development of several experimental migraine provocation models has significantly contributed to an understanding of the signaling mechanisms of migraine. The early history of this development and a view to the future are …
View article: Molecular nociceptive mechanisms in migraine: The migraine cascade
Molecular nociceptive mechanisms in migraine: The migraine cascade Open
Objective This review will explore the categorization of migraine‐provoking molecules, their cellular actions, site of action and potential drug targets based on the migraine cascade model. Methods Personal experience and literature. Resul…
View article: HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study
HMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study Open
View article: Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors
Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors Open
View article: The World Health Organization Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders and the headache revolution: from headache burden to a global action plan for headache disorders
The World Health Organization Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders and the headache revolution: from headache burden to a global action plan for headache disorders Open
View article: The International Classification of Headache Disorders: History and future perspectives
The International Classification of Headache Disorders: History and future perspectives Open
Purpose The International Classification of Headache Disorders (ICHD) is universally accepted and forms the basis of headache management and clinical, experimental and pharmacological headache research. The present review summarizes the hi…
View article: Dopamine Agonist Treatment Normalizes Neck Motor Dyscoordination and Relieves Pain in Chronic Tension-Type Headache and Whiplash. A Pilot Study
Dopamine Agonist Treatment Normalizes Neck Motor Dyscoordination and Relieves Pain in Chronic Tension-Type Headache and Whiplash. A Pilot Study Open
View article: Proposed general diagnostic criteria for secondary headaches
Proposed general diagnostic criteria for secondary headaches Open
Background The distinction between a pre-existing primary headache and a secondary headache at the onset of a disorder is important and has not been taken into account in the International Classification of Headache Disorders-3. This study…
View article: From fragmentation to collaboration in European brain research
From fragmentation to collaboration in European brain research Open
Background The European Academy of Neurology (EAN) is a member of the European Brain Council (EBC), a coalition of neurologists, psychiatrists, neurosurgeons, neuroscientists, patient organizations and industry with an interest in the brai…
View article: Xenobiotic Exposure and Migraine-Associated Signaling: A Multimethod Experimental Study Exploring Cellular Assays in Combination with <i>Ex Vivo</i> and <i>In Vivo</i> Mouse Models
Xenobiotic Exposure and Migraine-Associated Signaling: A Multimethod Experimental Study Exploring Cellular Assays in Combination with <i>Ex Vivo</i> and <i>In Vivo</i> Mouse Models Open
Here we show that multiple environmental pollutants interact with the TRPA1-CGRP migraine pain pathway. The data provide valuable insights into how environmental chemicals can interact with neurobiology and provide a potential mechanism fo…
View article: Evaluation of the ICHD-3 diagnostic criteria for cardiac cephalalgia and new proposal
Evaluation of the ICHD-3 diagnostic criteria for cardiac cephalalgia and new proposal Open
Background The current International Classification of Headache Disorders, 3rd edition (ICHD-3) diagnostic criteria for cardiac cephalalgia were established according to previous case reports and the opinion of experts. We aimed to assess …
View article: Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura
Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura Open
View article: Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030
Rethinking headache as a global public health case model for reaching the SDG 3 HEALTH by 2030 Open
The 2030 Agenda for Sustainable Development sets out, through 17 Sustainable Development Goals (SDGs), a path for the prosperity of people and the planet. SDG 3 in particular aims to ensure healthy lives and promote well-being for all at a…
View article: Multi-omic analyses of triptan-treated migraine attacks gives insight into molecular mechanisms
Multi-omic analyses of triptan-treated migraine attacks gives insight into molecular mechanisms Open
Migraine is a common, polygenic disorder that is characterized by moderate to severe headache attacks. Migraine attacks are commonly treated with triptans, i.e. serotonin receptor agonists. However, triptans are effective in ~ 60% of the p…