Tor A. Strand
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View article: Impact of an integrated intervention package during preconception, pregnancy, and early childhood on inflammation, IGF-1, IGFBP3 during first 6 months of life: Findings from the WINGS randomized controlled trial
Impact of an integrated intervention package during preconception, pregnancy, and early childhood on inflammation, IGF-1, IGFBP3 during first 6 months of life: Findings from the WINGS randomized controlled trial Open
Early-life interventions targeting maternal and child health, nutrition, and psychosocial care may influence infant growth and immune development by modulating systemic inflammation and growth factor pathways. However, causal evidence on c…
View article: Zinc as adjunct treatment for clinical severe infection in young infants: A randomized double-blind placebo-controlled trial in India and Nepal
Zinc as adjunct treatment for clinical severe infection in young infants: A randomized double-blind placebo-controlled trial in India and Nepal Open
Background Annually, an estimated 2.3 million infants die within their first month of life, primarily in sub-Saharan Africa and South Asia. Infections, including sepsis are among the major contributors to these deaths. Effective interventi…
View article: The effect of plasma donation frequency on total serum protein, immunoglobulin G and donor safety: A non‐inferiority randomized controlled trial
The effect of plasma donation frequency on total serum protein, immunoglobulin G and donor safety: A non‐inferiority randomized controlled trial Open
Background and Objectives The safety of varying plasma donation frequencies remains unclear. This non‐inferiority randomized controlled trial investigated the effect of plasma donation frequency on total serum protein (TSP), immunoglobulin…
View article: Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on inflammation, IGF-1, IGFBP3 during first 6 months of life: Findings from the WINGS Randomized Controlled Trial
Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on inflammation, IGF-1, IGFBP3 during first 6 months of life: Findings from the WINGS Randomized Controlled Trial Open
Background Early-life interventions targeting maternal and child health, nutrition, and psychosocial care may influence infant growth and immune development by modulating systemic inflammation and growth factor pathways. However, causal ev…
View article: 446. ANTIDEPRESSANT ACTIVITY OF STRATEGIC ELECTRICAL STIMULATION OF PREFRONTOCORTICAL NEURONS PRIMED FOR EXCITABILITY
446. ANTIDEPRESSANT ACTIVITY OF STRATEGIC ELECTRICAL STIMULATION OF PREFRONTOCORTICAL NEURONS PRIMED FOR EXCITABILITY Open
Background Major depressive disorder is a severe and pervasive mental health condition that significantly disrupts the well-being and daily functioning of those affected. Despite the availability of various treatment options, their efficac…
View article: 471. MATERNAL IMMUNE ACTIVATION LEADS TO SCHIZOPHRENIA-RELATED BEHAVIOURAL AND NEUROPHYSIOLOGICAL DEFICITS IN MOTHERS AND JUVENILE OFFSPRING
471. MATERNAL IMMUNE ACTIVATION LEADS TO SCHIZOPHRENIA-RELATED BEHAVIOURAL AND NEUROPHYSIOLOGICAL DEFICITS IN MOTHERS AND JUVENILE OFFSPRING Open
Background Effectively treating schizophrenia remains a significant challenge, particularly in addressing the full spectrum of symptoms following the initial onset. Current interventions often focus on individuals at high risk of developin…
View article: 363. DIFFERENTIAL EFFECTS OF PSILOCYBIN AND LISURIDE ON SEROTONIN AND DOPAMINE NEURONAL ACTIVITY AND BEHAVIOR
363. DIFFERENTIAL EFFECTS OF PSILOCYBIN AND LISURIDE ON SEROTONIN AND DOPAMINE NEURONAL ACTIVITY AND BEHAVIOR Open
Background Psychedelics hold potential as therapeutics in psychological disorders. Even if they primarily act on 5-HT2A receptors, their mechanisms and effects on the brain are not well understood. Simply activating 5-HT2A receptors does n…
View article: Association of Mild-to-Moderate Iodine Deficiency With Thyroid Function—A Systematic Review and Meta-analysis
Association of Mild-to-Moderate Iodine Deficiency With Thyroid Function—A Systematic Review and Meta-analysis Open
The only known function of iodine in the human body is as a component of thyroid hormones. Thus, all consequences of iodine deficiency should be mediated through altered thyroid hormone production. Although it is well established that seve…
View article: Infant vitamin B12 status and its predictors – cross-sectional baseline results from an ongoing randomized controlled trial
Infant vitamin B12 status and its predictors – cross-sectional baseline results from an ongoing randomized controlled trial Open
A substantial proportion of Norwegian infants have biochemical signs of low vitamin B12 status, given that the cut-offs were established in adults. Lower status was observed in partially and exclusively breastfed infants, compared with non…
View article: Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on the Gut Microbiome at Six Months of Age: Findings from the Women and Infants Integrated Growth Study (WINGS) Randomized Controlled Trial
Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on the Gut Microbiome at Six Months of Age: Findings from the Women and Infants Integrated Growth Study (WINGS) Randomized Controlled Trial Open
The findings indicate that improving maternal and infant health, nutrition, and psychosocial conditions enhances the relative abundance of beneficial gut bacteria at 6 mo of age, supporting healthy growth and development. This trial was re…
View article: Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset
Development and validation of a novel clinical risk score to predict hypoxaemia in children with pneumonia using the WHO PREPARE dataset Open
Background Hypoxaemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to de…
View article: Infant-level and child-level predictors of mortality in low-resource settings: the WHO Child Mortality Risk Stratification Multi-Country Pooled Cohort
Infant-level and child-level predictors of mortality in low-resource settings: the WHO Child Mortality Risk Stratification Multi-Country Pooled Cohort Open
For the Spanish and French translations of the abstract see Supplementary Materials section.
View article: One-Year Daily Micronutrient Supplementation and Anemia Prevalence Among Mildly Stunted Infants in Bhaktapur, Nepal
One-Year Daily Micronutrient Supplementation and Anemia Prevalence Among Mildly Stunted Infants in Bhaktapur, Nepal Open
Objectives: To describe the burden of anemia at 6 to 11 months and the change in anemia prevalence after 1 year of multi-micronutrient supplementation. Methods: We analyzed hemoglobin concentration twice in 569 children. First when they we…
View article: Reference Ranges and Determinants of Thyroid Function and TSH Receptor Antibodies During Early Pregnancy in Nepal
Reference Ranges and Determinants of Thyroid Function and TSH Receptor Antibodies During Early Pregnancy in Nepal Open
Objective Different definitions of thyroid dysfunction during pregnancy may lead to under or overtreatment. The aims of this study were to (1) define population‐based pregnancy‐specific reference ranges for thyroid dysfunction during early…
View article: Quantification of persistent organic pollutants in breastmilk and estimated infant intake, Norway
Quantification of persistent organic pollutants in breastmilk and estimated infant intake, Norway Open
Persistent organic pollutants (POPs) are environmental contaminants that can accumulate in human tissues and pose potential health risks. Despite global efforts to reduce their prevalence, follow‐up studies are needed to see if the measure…
View article: Cohort profile: the WHO Child Mortality Risk Stratification Multi-Country Pooled Cohort (WHO-CMRS) to identify predictors of mortality through early childhood
Cohort profile: the WHO Child Mortality Risk Stratification Multi-Country Pooled Cohort (WHO-CMRS) to identify predictors of mortality through early childhood Open
Purpose To provide details of a pooled data set that will be used to estimate absolute and relative mortality risks and other outcomes among children less than 59 months of age and the predictive performance of common risk exposures, both …
View article: Stability and predictability of Bayley Scales of Infant and Toddler Development: evidence from a south Indian birth cohort prospective study
Stability and predictability of Bayley Scales of Infant and Toddler Development: evidence from a south Indian birth cohort prospective study Open
Objectives There is limited information about the stability and predictability of Bayley Scales of Infant and Toddler Development (BSID) assessing child development in low- and middle-income settings. The objective of the present study was…
View article: Enteroviruses, Respiratory Syncytial Virus and Seasonal Coronaviruses in Influenza-like Illness Cases in Nepal
Enteroviruses, Respiratory Syncytial Virus and Seasonal Coronaviruses in Influenza-like Illness Cases in Nepal Open
Acute respiratory infection is one of the leading causes of morbidity and mortality among children in low- and middle-income countries. Due to limited diagnostic capability, many respiratory pathogens causing influenza-like illness go unde…
View article: The relationship between the ages and stages questionnaire, 3rd edition scores in early childhood and future cognitive abilities in young Nepalese children
The relationship between the ages and stages questionnaire, 3rd edition scores in early childhood and future cognitive abilities in young Nepalese children Open
Background The Ages and Stages Questionnaire 3rd edition (ASQ-3) could be a feasible tool in resource-poor settings. Little is known on the relationship between scores on the ASQ-3 and later intellectual abilities in these settings. Aims T…
View article: Is home environment associated with child fluid reasoning abilities in middle childhood in high-risk settings? findings from a cross-sectional study in Pakistan
Is home environment associated with child fluid reasoning abilities in middle childhood in high-risk settings? findings from a cross-sectional study in Pakistan Open
Background Evidence from low- and middle-income countries (LMIC) suggests that home environment is associated with early childhood development outcomes. However, studies from LMIC that have examined how the home environment during middle c…
View article: Trend analyses of persistent organic pollutants in human milk from first-time mothers in Norway between 2002 and 2021
Trend analyses of persistent organic pollutants in human milk from first-time mothers in Norway between 2002 and 2021 Open
Our study demonstrates a decline of most POPs in breast milk, likely attributed to international regulatory efforts like the Stockholm Convention. Notably, an increase in the 95th percentile concentrations of β-HCH, ∑2DDTs, and ∑6BDEs was …
View article: Epidemiology of overweight in under-five children in India: insights from National Family Health Survey
Epidemiology of overweight in under-five children in India: insights from National Family Health Survey Open
Childhood overweight is not only an immediate health concern due to its implications but also significantly increases the risk of persistent obesity and consequently CVD in the future, posing a serious threat to public health. The objectiv…
View article: Development and validation of a novel clinical risk score to predict hypoxemia in children with pneumonia using the WHO PREPARE dataset
Development and validation of a novel clinical risk score to predict hypoxemia in children with pneumonia using the WHO PREPARE dataset Open
Background Hypoxemia predicts mortality at all levels of care, and appropriate management can reduce preventable deaths. However, pulse oximetry and oxygen therapy remain inaccessible in many primary care health facilities. We aimed to dev…
View article: Epidemiology of Overweight in Under-Five Children in India: Insights from National Family Health Survey
Epidemiology of Overweight in Under-Five Children in India: Insights from National Family Health Survey Open
Childhood overweight is not only an immediate health concern due to its implications but also significantly increases the risk of persistent obesity and consequently cardiovascular diseases in the future, posing a serious threat to public …