Bertrand L. Jaber
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View article: Bile cast nephropathy: A systematic review of case reports and case series
Bile cast nephropathy: A systematic review of case reports and case series Open
BACKGROUND Bile cast nephropathy (BCN) is suspected in the setting of liver disease and hyperbilirubinemia and is characterized by the formation of tubular bile casts and acute tubular injury. While postmortem studies reveal a high prevale…
View article: Using Genotypes of The GH Gene as Selective Marker in Genetic Prediction: A Review
Using Genotypes of The GH Gene as Selective Marker in Genetic Prediction: A Review Open
Numerous genes influence economically significant quantitative traits, and each gene affects the trait somewhat. If the breeder can find the major gene loci that control economically important traits, they can be directly selected for gene…
View article: Biosensing Technologies and Their Applications in Medical Diagnostics
Biosensing Technologies and Their Applications in Medical Diagnostics Open
View article: Minimal change disease in treatment-naïve hepatitis C virus infection: A case report and literature review
Minimal change disease in treatment-naïve hepatitis C virus infection: A case report and literature review Open
Minimal change disease (MCD) accounts for 10 - 15% of idiopathic nephrotic syndromes in adults. Chronic hepatitis C virus (HCV) infection is rarely ascribed as a cause of MCD and was previously associated with interferon-based therapy. MCD…
View article: 2789. Cefepime Versus Non-Cefepime/Non-Carbapenem Therapy for Blood Stream Infections Caused by Non-ESBL-Producing <i>Serratia Marcescens</i>: A Subgroup Analysis of The <i>Carbapenem-Serratia</i> Multicenter Retrospective Cohort Study
2789. Cefepime Versus Non-Cefepime/Non-Carbapenem Therapy for Blood Stream Infections Caused by Non-ESBL-Producing <i>Serratia Marcescens</i>: A Subgroup Analysis of The <i>Carbapenem-Serratia</i> Multicenter Retrospective Cohort Study Open
Background Serratia Marcescens causes serious infections. Carbapenems were prescribed due to the bacterium’s ability to develop inducible AmpC-mediated resistance. Recent IDSA guidance recommends ceftriaxone and in high-burden cases, cefep…
View article: 2787. Carbapenem Versus Non-Carbapenem Based Therapy for Blood Stream Infection Caused by <i>Serratia Marcescen</i>s: A Multicenter Retrospective Cohort Study
2787. Carbapenem Versus Non-Carbapenem Based Therapy for Blood Stream Infection Caused by <i>Serratia Marcescen</i>s: A Multicenter Retrospective Cohort Study Open
Background Carbapenems were commonly prescribed for "SPACE" organisms. Recent IDSA guidance recommends narrower-spectrum beta-lactams for lower AmpC-induction risk bacteria, like Serratia. Prior studies focused on other Enterobacterales, w…
View article: 2788. Cefepime or Carbapenem Definitive Therapy Versus Other Antibiotics for Blood Stream Infections Caused by Non-ESBL-Producing <i>Serratia Marcescens</i>: A Multicenter Retrospective Cohort Study
2788. Cefepime or Carbapenem Definitive Therapy Versus Other Antibiotics for Blood Stream Infections Caused by Non-ESBL-Producing <i>Serratia Marcescens</i>: A Multicenter Retrospective Cohort Study Open
Background Serratia Marcescens causes serious infections. Carbapenems were preferred due to fear of inducible AmpC resistance. IDSA guidance now recommends ceftriaxone, and in high-burden cases, cefepime. Evidence on Serratia bacteremia tr…
View article: Implementation of a palliative care consultation trigger tool for hospitalised patients with acute decompensated heart failure
Implementation of a palliative care consultation trigger tool for hospitalised patients with acute decompensated heart failure Open
Heart failure is a leading cause of hospitalisations. Integration of palliative care services with medical therapy in the management of hospitalised patients with heart failure is imperative. Unfortunately, there are no standardised criter…
View article: Acute on chronic bilateral renal vein thrombosis in the setting of remission of class V lupus nephritis: A case report and literature review
Acute on chronic bilateral renal vein thrombosis in the setting of remission of class V lupus nephritis: A case report and literature review Open
Renal vein thrombosis (RVT), defined as the presence of a thrombus in the major renal vein or one of its tributaries, can present acutely or go unnoticed resulting in acute kidney injury or chronic kidney disease. RVT is associated with mu…
View article: Improving compliance with appropriateness of testing for heparin-induced thrombocytopaenia: a quality improvement report
Improving compliance with appropriateness of testing for heparin-induced thrombocytopaenia: a quality improvement report Open
Heparin-induced thrombocytopaenia (HIT) is a serious complication of heparin therapy. Evidence-based guidelines recommend the use of the 4Ts scoring system to calculate pretest probability of HIT. However, this scoring system is often unde…
View article: Factors Associated with Severity of Acute Kidney Injury and Adverse Outcomes in Critically Ill Patients with COVID-19
Factors Associated with Severity of Acute Kidney Injury and Adverse Outcomes in Critically Ill Patients with COVID-19 Open
Background: Acute kidney injury (AKI) is a well-recognized complication of coronavirus disease 2019 (COVID-19). The short and long-term outcomes of patients who develop AKI have not been well characterized. Methods:…
View article: Country‐level determinants of COVID‐19 case rates and death rates: An ecological study
Country‐level determinants of COVID‐19 case rates and death rates: An ecological study Open
The Coronavirus Disease 2019 (COVID‐19) pandemic has had a variable worldwide impact, likely related to country‐level characteristics. In this ecological study, we explored the association of COVID‐19 case rates (per 100,000 people) and de…
View article: Determinants of COVID-19 Case and Death Rates: An Ecological Study
Determinants of COVID-19 Case and Death Rates: An Ecological Study Open
Introduction: The Coronavirus Disease 2019 (COVID-19) pandemic has had a variable worldwide impact, likely related to country-level characteristics. In this ecological study, we explored the association of COVID-19 case rates (per 100,000 …
View article: Hospital-acquired acute kidney injury: a proposed patient safety indicator
Hospital-acquired acute kidney injury: a proposed patient safety indicator Open
Patient safety, which includes adverse event reporting and routine collection of outcome measures, has become an increasingly important aspect of inpatient care worldwide. In the United States, the National Quality Forum leads the effort i…
View article: Revising the Maximal Contrast Dose for Predicting Acute Kidney Injury following Coronary Intervention
Revising the Maximal Contrast Dose for Predicting Acute Kidney Injury following Coronary Intervention Open
Introduction: The maximal allowable contrast dose (MACD = 5 × body weight/serum creatinine) is an empiric equation that has been used and validated in several studies to mitigate the risk of contrast-induced acute kidney injury (CI-AKI). H…
View article: 698. 8 Years of Infective Endocarditis in Intravenous and Non-Intravenous Drug Users a Single Center Experience
698. 8 Years of Infective Endocarditis in Intravenous and Non-Intravenous Drug Users a Single Center Experience Open
Background Despite advances in diagnosis and management, infective endocarditis (IE) is associated with considerable morbidity and mortality. Given the emergence of drug- resistant organisms, it is unclear whether this has impacted the cha…
View article: 697. 8 Years of Characteristics and Outcomes of Patients with MRSA Endocarditis Based on Vancomycin Minimum Inhibitory Concentration: Experience at a Tertiary Care Hospital
697. 8 Years of Characteristics and Outcomes of Patients with MRSA Endocarditis Based on Vancomycin Minimum Inhibitory Concentration: Experience at a Tertiary Care Hospital Open
Background Vancomycin has been the mainstay of treatment for methicillin-resistant Staphylococcus aureus (MRSA) infective endocarditis (IE). MRSA reduced susceptibility to vancomycin is a growing threat. Data assessing the effect of vancom…
View article: Design and implementation of an academic enrichment program to improve performance on the internal medicine in-training exam
Design and implementation of an academic enrichment program to improve performance on the internal medicine in-training exam Open
The internal medicine In-Training Exam (ITE) is administered at residency training programs to assess medical knowledge. Our internal medicine residency program witnessed a performance decline on the ITE between 2011 and 2014. The goal of …
View article: Proton pump inhibitors and hypomagnesemia
Proton pump inhibitors and hypomagnesemia Open
Background: Previous meta-analyses have suggested that there might be an association between the use of proton pump inhibitors (PPIs) and the development of hypomagnesemia, although the conclusions were no definitive. Methods: To provide a…
View article: Effect of dialysate potassium and lactate on serum potassium and bicarbonate concentrations during daily hemodialysis at low dialysate flow rates
Effect of dialysate potassium and lactate on serum potassium and bicarbonate concentrations during daily hemodialysis at low dialysate flow rates Open
Control of serum potassium and bicarbonate concentrations during daily HD at low dialysate flow rates is readily achievable; the choice of dialysate potassium and lactate concentration can be informed when transfer is from in-center HD to …
View article: A quality improvement project to reduce overutilization of blood tests in a teaching hospital
A quality improvement project to reduce overutilization of blood tests in a teaching hospital Open
Objective: In hospitals, physicians-in-training are major contributors to the burden of tests ordered, increasing cost and resource utilization. We implemented an intervention to discourage overutilization of the complete blood coun…
View article: The Authors Reply
The Authors Reply Open
We thank Dr. Legrand for his comments regarding hydroxocobalamin as a cause of oxalate nephropathy. We opted to exclude patients with short-term exposure (<30 days) to hyperoxaluria-enabling conditions, as we assumed that these would be mo…
View article: Treatment of Calciphylaxis in CKD: A Systematic Review and Meta-analysis
Treatment of Calciphylaxis in CKD: A Systematic Review and Meta-analysis Open
View article: Secondary Oxalate Nephropathy: A Systematic Review
Secondary Oxalate Nephropathy: A Systematic Review Open
Secondary oxalate nephropathy is a rare but potentially devastating condition. Renal replacement therapy is required in >50% of patients, and most patients remain dialysis-dependent. Studies are needed for effective preventive and treatmen…
View article: Rituximab for retroperitoneal fibrosis due to IgG4-related disease: A case report and literature review
Rituximab for retroperitoneal fibrosis due to IgG4-related disease: A case report and literature review Open
Retroperitoneal fibrosis (RPF) is a progressive fibroinflammatory disease that can be complicated by urinary obstruction. RPF can be the only manifestation of IgG4-related disease (IgG4-RD). Treatment of IgG4-related RPF is challenging and…
View article: Supplementary Material for: Cinacalcet for Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: A Meta-Analysis of Randomized Controlled Trials
Supplementary Material for: Cinacalcet for Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: A Meta-Analysis of Randomized Controlled Trials Open
Background: Cinacalcet could decrease serum calcium, phosphate, and parathyroid hormone (PTH) in previous meta-analyses. However, the effect of cinacalcet on the new biomarkers such as fibroblast growth factor-23 (FGF-23), bo…
View article: Maximum allowable contrast dose and prevention of acute kidney injury following cardiovascular procedures
Maximum allowable contrast dose and prevention of acute kidney injury following cardiovascular procedures Open
Prevention of CI-AKI must remain a clinical priority. Intraprocedural preventive measures should include a priori calculation of the MACD and contrast volume to eGFR ratio to limit contrast volume. Other measures may include the adoption o…
View article: Erratum
Erratum Open
View article: Plasmapheresis for treatment of immune complex-mediated glomerulonephritis in infective endocarditis: a case report and literature review
Plasmapheresis for treatment of immune complex-mediated glomerulonephritis in infective endocarditis: a case report and literature review Open
We report the case of a 57-year-old man who presented with subacute bacterial endocarditis secondary to Streptococcus mutans complicated by biopsy-proven immune complex-mediated glomerulonephritis (ICGN). Despite initial treatment w…
View article: Mineralocorticoid Receptor Blockade for Prevention of Acute Kidney Injury: An Elusive Target
Mineralocorticoid Receptor Blockade for Prevention of Acute Kidney Injury: An Elusive Target Open