Aaron Wright
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View article: CSIG-33. NF2 LOSS MODULATES HIPPO SIGNALING IN NF1 MUTANT MALIGNANT PERIPHERAL NERVE SHEATH TUMORS
CSIG-33. NF2 LOSS MODULATES HIPPO SIGNALING IN NF1 MUTANT MALIGNANT PERIPHERAL NERVE SHEATH TUMORS Open
NF1 and NF2 are recurrently mutated in peripheral nervous system (PNS) tumors, yet a mechanistic link connecting these tumor suppressors remains elusive. Here, we combine proteomics, genomics, and biochemical analysis of patient derived ce…
View article: Correction: Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region
Correction: Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region Open
[This corrects the article DOI: 10.1371/journal.pone.0250586.].
View article: A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system
A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system Open
The NF1 tumor suppressor gene is recurrently mutated in human cancers and is associated with the neurofibromatosis type 1 (NF-1) cancer predisposition syndrome. NF1 encodes neurofibromin, a Ras guanosine triphosphate (GTPase) activating pr…
View article: Comprehensive identification of β-lactam antibiotic polypharmacology in <i>Mycobacterium tuberculosis</i>
Comprehensive identification of β-lactam antibiotic polypharmacology in <i>Mycobacterium tuberculosis</i> Open
Infections with Mycobacterium tuberculosis ( Mtb ) cause tuberculosis (TB), which requires at least six months of treatment with multiple antibiotics. There is emergent interest in using β-lactam antibiotics to improve treatment outcomes f…
View article: Discovery of non-opioid receptor protein targets of fentanyl and remifentanil by affinity-based protein profiling in diverse animal model and human tissues
Discovery of non-opioid receptor protein targets of fentanyl and remifentanil by affinity-based protein profiling in diverse animal model and human tissues Open
Synthetic opioids such as fentanyl and related analogs have been widely used for pain management. However, their negative side effects, including respiratory depression and high potential for addiction, underscore the need for a deeper und…
View article: Selective capture, isolation, and characterization of mucin foraging neu-raminidase-active bacteria from microbiomes using a non-inhibitory activ-ity-based probe
Selective capture, isolation, and characterization of mucin foraging neu-raminidase-active bacteria from microbiomes using a non-inhibitory activ-ity-based probe Open
Neuraminidase is expressed by some bacteria in host-associated environments to cleave terminal sialic acid residues from mucin layers. This activity has been associated with nutrient acquisition, biofilm formation, and host infection, and …
View article: Activity-Based Protein Profiling to Probe Relationships between Cytochrome P450 Enzymes and Early-Age Metabolism of Two Polycyclic Aromatic Hydrocarbons (PAHs): Phenanthrene and Retene
Activity-Based Protein Profiling to Probe Relationships between Cytochrome P450 Enzymes and Early-Age Metabolism of Two Polycyclic Aromatic Hydrocarbons (PAHs): Phenanthrene and Retene Open
A growing body of literature has linked early-life exposures to polycyclic aromatic hydrocarbons (PAH) with adverse neurodevelopmental effects. Once in the body, metabolism serves as a powerful mediator of PAH toxicity by bioactivating and…
View article: Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression<i>in planta</i>
Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression<i>in planta</i> Open
Eukaryotes produce a large number of cytochrome P450s that mediate the synthesis and degradation of diverse endogenous and exogenous metabolites. Yet, most of these P450s are uncharacterized and global tools to study these challenging, mem…