Toshio Suda
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View article: Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2
Prospective isolation of mouse and human hematopoietic stem cells using PLXDC2 Open
Numerous strategies exist to isolate hematopoietic stem cells (HSCs) using complex combinations of markers and flow cytometry. However, robust identification of HSCs using imaging techniques is substantially more challenging which has prom…
View article: Comparative transcriptome atlas as an assistive modality for complex classification of rare kidney cancers
Comparative transcriptome atlas as an assistive modality for complex classification of rare kidney cancers Open
There is a great unmet medical need for development of molecularly characterizing modalities to assist in the complex classification of rare kidney cancers, some of which are diagnosed as unclassified renal cell carcinoma (unclassified RCC…
View article: Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity
Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity Open
Innovative identification technologies for hematopoietic stem cells (HSCs) have expanded the scope of stem cell biology. Clinically, the functional quality of HSCs critically influences the safety and therapeutic efficacy of stem cell ther…
View article: Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop
Aging-declined RNA exportation impairs hematopoietic stem cells by inducing R-loop Open
Aging-related accumulation of DNA damage adversely affects hematopoietic stem cell (HSC). However, the mechanisms underlying this accumulation and strategies for its elimination to rejuvenate aged HSCs remain largely obscure. This study un…
View article: Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of “Super” transplantability
Heterogeneity of high-potency multilineage hematopoietic stem cells and identification of “Super” transplantability Open
Hematopoietic stem cells (HSCs) are heterogeneous, and the quality of HSCs—that is, transplantability—is a key determinant for posttransplant hematopoietic reconstitution. However, molecular modalities of high-potency HSCs with superior tr…
View article: Ex Vivo Expansion of Human Serial Transplantable Haematopoietic Stem Cells
Ex Vivo Expansion of Human Serial Transplantable Haematopoietic Stem Cells Open
The scarcity of haematopoietic stem cells (HSCs) limits clinical HSC transplantation, a curative therapy for various blood disorders. Although substantial advances have been made in the ex vivo expansion of HSCs, the expansion of long-term…
View article: Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis
Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis Open
Mitochondrial tRNA taurine modifications mediated by mitochondrial tRNA translation optimization 1 ( Mto1 ) is essential for the mitochondrial protein translation. Mto1 deficiency was shown to induce proteostress in embryonic stem cells. A…
View article: Microenvironmental dynamics in steady-state and stress erythropoiesis
Microenvironmental dynamics in steady-state and stress erythropoiesis Open
Anemia is a condition marked by a shortage of red blood cells or hemoglobin, resulting in a diminished ability of the blood to carry oxygen. In response to anemia or hypoxia, the body activates a compensatory mechanism known as stress eryt…
View article: Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation
Progenitor effect in the spleen drives early recovery via universal hematopoietic cell inflation Open
Hematopoietic stem cells (HSCs) possess the capacity to regenerate the entire hematopoietic system. However, the precise HSC dynamics in the early post-transplantation phase remain an enigma. Clinically, the initial hematopoiesis in the po…
View article: Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture
Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture Open
Hematopoietic stem cells (HSCs) develop from hemogenic endothelial cells (HECs) during mouse embryogenesis. Understanding the signaling molecules required for HSC development is crucial for the in vitro derivation of HSCs. We previously in…
View article: Noncanonical <scp>TCA</scp> cycle fosters canonical <scp>TCA</scp> cycle and mitochondrial integrity in acute myeloid leukemia
Noncanonical <span>TCA</span> cycle fosters canonical <span>TCA</span> cycle and mitochondrial integrity in acute myeloid leukemia Open
Cancer cells rely on mitochondrial oxidative phosphorylation (OXPHOS) and the noncanonical tricarboxylic acid (TCA) cycle. In this paper, we shed light on the vital role played by the noncanonical TCA cycle in a host‐side concession to mit…
View article: Deciphering MARCH5’s impact on multiple myeloma: insights into autophagy regulation and AKT-FOXO3 signaling
Deciphering MARCH5’s impact on multiple myeloma: insights into autophagy regulation and AKT-FOXO3 signaling Open
Multiple myeloma (MM) stands as a formidable blood malignancy, necessitating innovative therapeutic approaches. Excessive immunoglobulin production within myeloma cells leads to a buildup of toxic proteins, and autophagy plays a crucial ro…
View article: Prospective isolation of mouse and human hematopoietic stem cells using Plexin domain containing 2
Prospective isolation of mouse and human hematopoietic stem cells using Plexin domain containing 2 Open
Numerous strategies exist to isolate hematopoietic stem cells (HSCs) using complex combinations of markers and flow cytometry. However, robust identification of HSCs using imaging techniques is substantially more challenging which has prom…
View article: Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity
Quantitative phase imaging with temporal kinetics predicts hematopoietic stem cell diversity Open
Innovative identification technologies for hematopoietic stem cells (HSCs) have advanced the frontiers of stem cell biology. However, most analytical techniques capture only a single snapshot, disregarding the temporal context. A comprehen…
View article: Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells
Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells Open
Hematopoietic stem cells (HSCs) develop from hemogenic endothelial cells (HECs) in vivo during mouse embryogenesis. When cultured in vitro, cells from the embryo phenotypically defined as pre-HSC-I and pre-HSC-II have the potential to diff…
View article: METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity
METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity Open
Epitranscriptomic RNA modifications are crucial for the maintenance of glioma stem cells (GSCs), the most malignant cells in glioblastoma (GBM). 3-methylcytosine (m 3 C) is a new epitranscriptomic mark on RNAs and METTL8 represents an m 3 …
View article: Author response: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
Author response: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Article and author information Abstract Metabolic pathways are plas…
View article: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis
Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis Open
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cell…
View article: Deciphering the regulatory landscape of murine splenic response to anemic stress at single-cell resolution
Deciphering the regulatory landscape of murine splenic response to anemic stress at single-cell resolution Open
Stress erythropoiesis can be influenced by multiple mediators through both intrinsic and extrinsic mechanisms in early erythroid precursors. Single-cell RNA sequencing was conducted on spleen tissue isolated from mice subjected to phenylhy…
View article: HAPLOINSUFFICIENCY OF TIE2 IN MUTATED BLOOD CELLS SUPPRESS ANGIOGENESIS IN THE BONE MARROW AND INHIBIT PROGRESSION OF MDS
HAPLOINSUFFICIENCY OF TIE2 IN MUTATED BLOOD CELLS SUPPRESS ANGIOGENESIS IN THE BONE MARROW AND INHIBIT PROGRESSION OF MDS Open
Introduction: Tie2 is a receptor tyrosine kinase and regulates angiogenesis and vascular quiescence. Given that Tie2 modulates microvascular density in cancer, we hypothesized that deletion of Tie2 in blood cells can inhibit progression of…
View article: Review #1 (Public Review): Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Review #1 (Public Review): Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis Open
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cell…
View article: Author Response: Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Author Response: Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis Open
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cell…
View article: Review #2 (Public Review): Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Review #2 (Public Review): Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis Open
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cell…
View article: Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis
Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis Open
Metabolic pathways are plastic and rapidly change in response to stress or perturbation. Current metabolic profiling techniques require lysis of many cells, complicating the tracking of metabolic changes over time after stress in rare cell…
View article: Phospholipid metabolic adaptation promotes survival of <i>IDH2</i> mutant acute myeloid leukemia cells
Phospholipid metabolic adaptation promotes survival of <i>IDH2</i> mutant acute myeloid leukemia cells Open
Genetic mutations in the isocitrate dehydrogenase ( IDH ) gene that result in a pathological enzymatic activity to produce oncometabolite have been detected in acute myeloid leukemia (AML) patients. While specific inhibitors that target mu…