Jian Wu
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View article: Chromatin accessibility derived from cfDNA serves as a novel classification biomarker of glioma
Chromatin accessibility derived from cfDNA serves as a novel classification biomarker of glioma Open
Introduction Gliomas can be classified by their molecular characteristics, which are also closely associated with clinical outcomes. Cell-free DNA (cfDNA)-based liquid biopsy in gliomas is challenging because of the limited amount of tumor…
View article: A review of immunometabolic crosstalk in PCOS-related pregnancy loss: mechanisms and emerging therapeutic strategies
A review of immunometabolic crosstalk in PCOS-related pregnancy loss: mechanisms and emerging therapeutic strategies Open
PCOS-related miscarriage is increasingly recognized as resulting from dysregulation of immune-metabolic crosstalk. Mechanism-based, multidimensional strategies targeting this dual pathology represent a promising paradigm for preventing and…
View article: Stroboscopic training effects on athletic performance and cognitive function across populations, purposes, and skill types: a systematic review and meta-analysis of randomized controlled trials
Stroboscopic training effects on athletic performance and cognitive function across populations, purposes, and skill types: a systematic review and meta-analysis of randomized controlled trials Open
Background This systematic review and meta-analysis aimed to evaluate the effects of stroboscopic training on cognitive function and athletic performance across different populations, purposes, and skill types. Methods A comprehensive sear…
View article: Biodiversity regulates the asymmetric influence of forest cover gain and loss on land surface temperature
Biodiversity regulates the asymmetric influence of forest cover gain and loss on land surface temperature Open
Land surface temperature (LST) responses to forest gain and loss are highly asymmetric, with stronger cooling per unit gain than warming per unit loss, particularly in tropical and temperate regions. Although this asymmetry has been docume…
View article: Targeted C3G delivery by engineered milk exosomes for effective therapy in microplastics-induced colitis
Targeted C3G delivery by engineered milk exosomes for effective therapy in microplastics-induced colitis Open
Microplastic polystyrene (PS) ingestion through the food chain induces chronic colitis, with no effective intervention strategy, posing a public health concern globally. Cyanidin-3-O-glucoside (C3G), an anthocyanin abundant in red bayberry…
View article: Modelling the epidemiological impact and cost-effectiveness of possible changes to the meningococcal vaccination schedule for adolescents and young adults in the United States
Modelling the epidemiological impact and cost-effectiveness of possible changes to the meningococcal vaccination schedule for adolescents and young adults in the United States Open
Q-QB-B was the most cost-effective schedule. Scenarios replacing the MenACWY dose at age 16 years with MenABCWY were not cost-effective vs. Q-QB-B. While cost savings could result from eliminating the first MenACWY dose, this was estimated…
View article: FreeViBe+: An Enhanced Method for Moving Target Separation
FreeViBe+: An Enhanced Method for Moving Target Separation Open
An enhanced method called FreeViBe+ for moving target segmentation is proposed in this paper, addressing limitations in the ViBe algorithm such as ghosting, shadows, and holes. To eliminate ghosts, multi-frame background modeling is introd…
View article: Behavior-induced oscillations in epidemic outbreaks with distributed memory: Beyond the linear chain trick using numerical methods
Behavior-induced oscillations in epidemic outbreaks with distributed memory: Beyond the linear chain trick using numerical methods Open
We considered a model for an infectious disease outbreak, when the depletion of susceptible individuals is negligible, and assumed that individuals adapt their behavior according to the information they receive about new cases. In line wit…
View article: Holistic lignocellulosic biorefinery approach for co-production of L-lactic acid, flavonoids, and lignin from Euryale ferox seed shell feedstock
Holistic lignocellulosic biorefinery approach for co-production of L-lactic acid, flavonoids, and lignin from Euryale ferox seed shell feedstock Open
Euryale ferox seed shell (EFSS) is an agricultural waste biomass with abundant cellulose, hemicellulose, lignin and extractives. However, the complete valorization of EFSS to valuable products is still challenging. Herein, a holistic ligno…
View article: Multi-Feature Fusion for Fiber Optic Vibration Identification Based on Denoising Diffusion Probabilistic Models
Multi-Feature Fusion for Fiber Optic Vibration Identification Based on Denoising Diffusion Probabilistic Models Open
Fiber optic vibration identification has significant applications in engineering fields, like security surveillance and structural health assessment. However, present methods primarily depend on either temporal–frequency domain or image fe…
View article: Environmentally relevant concentrations of polystyrene nanoplastics induce Parkinson’s-like neurotoxicity in C. elegans via oxidative stress
Environmentally relevant concentrations of polystyrene nanoplastics induce Parkinson’s-like neurotoxicity in C. elegans via oxidative stress Open
This study reveals that environmentally relevant polystyrene nanoplastics (PS-NPs) induces Parkinson's disease (PD)-like pathology in Caenorhabditis elegans (C. elegans) through oxidative stress. Wild-type and transgenic strains were expos…
View article: Mild photothermal-mediated neuroimmunomodulatory composite hydrogel ameliorates bone healing microenvironment for enhanced osteoporotic bone defect regeneration
Mild photothermal-mediated neuroimmunomodulatory composite hydrogel ameliorates bone healing microenvironment for enhanced osteoporotic bone defect regeneration Open
The treatment of osteoporotic bone defects represents a substantial clinical challenge in contemporary orthopedics due to the abnormal accumulation of reactive oxygen species (ROS) and elevated inflammatory levels. Despite advances in bone…
View article: Moist orographic gravity wave drag parameterization reduces the bias of summer rainfall over the Tibetan Plateau
Moist orographic gravity wave drag parameterization reduces the bias of summer rainfall over the Tibetan Plateau Open
Summer precipitation over the Tibetan Plateau (TP) significantly affects the regional and global climate. In this paper, the orographic gravity wave drag (OGWD) parameterization is revised by incorporating the moisture effect of saturated …
View article: Exploring the spatiotemporal dynamics and driving mechanism of cropland ecosystem health: A perspective based on the contributions of climate change and human activities
Exploring the spatiotemporal dynamics and driving mechanism of cropland ecosystem health: A perspective based on the contributions of climate change and human activities Open
Under the combined influence of climate change and human activities, cropland ecosystem health (CEH) faces significant challenges. Understanding spatiotemporal dynamics and driving mechanisms is vital for advancing the national cropland po…
View article: Variation Characteristics of the Ionospheric E Layer over the Tibetan Plateau and Surrounding Areas During a Full Solar Cycle
Variation Characteristics of the Ionospheric E Layer over the Tibetan Plateau and Surrounding Areas During a Full Solar Cycle Open
The ionospheric E layer (90–150 km altitude) significantly influences ionospheric dynamics and plays a crucial role in radio wave propagation. The Tibetan Plateau, as the “Third Pole,” affects E-layer morphology due to its unique topograph…
View article: Unsupervised Optical-Sensor Extrinsic Calibration via Dual-Transformer Alignment
Unsupervised Optical-Sensor Extrinsic Calibration via Dual-Transformer Alignment Open
Accurate extrinsic calibration between optical sensors, such as camera and LiDAR, is crucial for multimodal perception. Traditional methods based on specific calibration targets exhibit poor robustness in complex optical environments such …
View article: Integrating Dietary Inflammatory Index and Triglyceride-Glucose Body Mass Index for Mortality Association in Hypertension
Integrating Dietary Inflammatory Index and Triglyceride-Glucose Body Mass Index for Mortality Association in Hypertension Open
DII and TyG-BMI are significant indices that may enhance personalized strategies for CVD prevention and management.
View article: Case Report: Adolescent epididymal cysts: three management approaches including a rare synchronous epididymal cyst and testicular torsion
Case Report: Adolescent epididymal cysts: three management approaches including a rare synchronous epididymal cyst and testicular torsion Open
Introduction Epididymal cysts are common benign lesions that typically present as painless scrotal masses. They predominantly occur in adult males but can also be found in adolescents, albeit with a higher likelihood of being overlooked at…
View article: Evaluating dynamic global vegetation models in China: challenges in capturing trends in leaf area and gross primary productivity
Evaluating dynamic global vegetation models in China: challenges in capturing trends in leaf area and gross primary productivity Open
Terrestrial ecosystems are crucial in mitigating global climate change, and dynamic global vegetation models (DGVMs) have become essential tools for simulating these ecosystems. However, uncertainties remain in DGVM simulations for China, …
View article: Value of nafamostat mesylate in venoarterial extracorporeal membrane oxygenation anticoagulation—A retrospective cross‐sectional study
Value of nafamostat mesylate in venoarterial extracorporeal membrane oxygenation anticoagulation—A retrospective cross‐sectional study Open
Background Anticoagulation is a key measure during venoarterial extracorporeal membrane oxygenation (VA‐ECMO) maintenance therapy. Nafamostat mesylate (NM) has emerged as a potential alternative to heparin. We assessed the value of anticoa…
View article: Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway
Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway Open
IRW-driven ACE2 upregulation in vivo relies on the dopamine/D1R signaling pathway, highlighting the therapeutic potential of this pathway for ACE2-related conditions.
View article: Multi-Layer Soil Moisture Profiling Based on BKA-CNN by Integrating Sentinel-1/2 SAR and Multispectral Data
Multi-Layer Soil Moisture Profiling Based on BKA-CNN by Integrating Sentinel-1/2 SAR and Multispectral Data Open
Soil moisture (SM) is crucial for ecosystems and agriculture. Since the root systems of plants absorb water at different depths with different intensities, monitoring multi-layer SM can better respond to the water demand of plants and offe…