Yu Chen
YOU?
Author Swipe
View article: Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis Open
Alzheimer's disease (AD) is a leading cause of mortality among the elderly. We performed a whole-genome sequencing study of AD in the Chinese population. In addition to the variants identified in or around the APOE locus (sentinel…
View article: ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L Open
View article: Review of Chinese medicine intervention in PI3K/AKT pathway to regulate fibrosis
Review of Chinese medicine intervention in PI3K/AKT pathway to regulate fibrosis Open
The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway plays a crucial role in the regulation of fibrosis, a pathological process characterized by excessive deposition of extracellular matrix components leading t…
View article: Genomic alterations in the YAP/TAZ pathway are associated with stem cell-like castration-resistant prostate cancer
Genomic alterations in the YAP/TAZ pathway are associated with stem cell-like castration-resistant prostate cancer Open
Castration-resistant prostate cancer (CRPC) is an aggressive disease exhibiting multiple epigenomic subtypes: androgen receptor-dependent CRPC-AR, and lineage plastic subtypes CRPC-SCL (stem cell-like), CRPC-WNT (Wnt-dependent), and CRPC-N…
View article: Reprogramming of human urine cells into cardiomyocytes via a small molecule cocktail in xeno-free conditions
Reprogramming of human urine cells into cardiomyocytes via a small molecule cocktail in xeno-free conditions Open
This study demonstrates the successful reprogramming of hUCs into functional hCiCMs using small molecules under xeno-free conditions, offering a scalable, autologous cell source for cardiac repair with significant potential for regenerativ…
View article: Disruption of TAD hierarchy promotes LTR co-option in cancer
Disruption of TAD hierarchy promotes LTR co-option in cancer Open
View article: BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature–positive castration-resistant prostate cancer
BET inhibitors reduce tumor growth in preclinical models of gastrointestinal gene signature–positive castration-resistant prostate cancer Open
A subgroup (~20%-30%) of castration-resistant prostate cancer (CRPC) aberrantly expresses a gastrointestinal (GI) transcriptome governed by 2 GI-lineage-restricted transcription factors, HNF1A and HNF4G. In this study, we found that expres…
View article: Pan-cancer analysis identifies DBF4B as an immunologic and prognostic biomarker
Pan-cancer analysis identifies DBF4B as an immunologic and prognostic biomarker Open
DBF4 zinc finger B (DBF4B) is a regulator of cellular CDC7 proteins, and the complex it forms with CDC7 proteins plays a key role in coordinating the initiation of DNA replication. Compared with previous DBF4B studies, this study is the fi…
View article: Corrigendum: Development and validation of a simulation training platform for the ligation of deep dorsal vein complex in radical prostatectomy
Corrigendum: Development and validation of a simulation training platform for the ligation of deep dorsal vein complex in radical prostatectomy Open
[This corrects the article DOI: 10.3389/fonc.2024.1407393.].
View article: A multi‐omics analysis reveals candidate genes for Cd tolerance in Paspalum vaginatum
A multi‐omics analysis reveals candidate genes for Cd tolerance in Paspalum vaginatum Open
Cadmium (Cd) pollution in the farmland has become a serious global issue threatening both human health and plant biomass production. Seashore paspalum (Paspalum vaginatum Sw.), a halophytic turfgrass, has been recognized as a Cd-tolerant s…
View article: Loss of <i>Kmt2c</i> / <i>d</i> promotes gastric cancer initiation and confers vulnerability to mTORC1 inhibition and anti-PD1 immunotherapy
Loss of <i>Kmt2c</i> / <i>d</i> promotes gastric cancer initiation and confers vulnerability to mTORC1 inhibition and anti-PD1 immunotherapy Open
KMT2C and KMT2D ( KMT2C/D ) are frequently mutated in gastric adenocarcinoma, yet their function in cancer initiation remains poorly understood. In this study, based on the observation that loss-of-function mutations of KMT2C and KMT2D are…
View article: Author Correction: LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
Author Correction: LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer Open
View article: Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis
Identification of GDP as a small inhibitory molecule in HepG2 cells by non‑targeted metabolomics analysis Open
Identifying the mechanism by which lipid metabolism regulates cancer may offer a novel approach for therapeutic intervention. It has previously been identified that a lipid metabolism-related factor, namely fatty acid hydroxylase domain co…
View article: Spatial proximity of CD8+ T cells to tumor cells predicts neoadjuvant therapy efficacy in breast cancer
Spatial proximity of CD8+ T cells to tumor cells predicts neoadjuvant therapy efficacy in breast cancer Open
The spatial proximity of CD8+ T cells to tumor cells critically influences the efficacy of neoadjuvant therapy (NAT) in breast cancer (BC). In this study, we evaluated whether the presence of CD8+ T cells and other im…
View article: Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers
Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers Open
Recent phase 3 clinical trial showed improved radiographic progression-free survival in PTEN-deficient prostate cancers treated with combined Akt and AR inhibition. Building on this and our previous research into PI3K and AR signaling inte…
View article: LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer
LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer Open
View article: Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters
Loss of Kmt2c or Kmt2d primes urothelium for tumorigenesis and redistributes KMT2A–menin to bivalent promoters Open
View article: β-Hydroxybutyrate Alleviates Atherosclerotic Calcification by Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis via AMPK/Nrf2 Pathway
β-Hydroxybutyrate Alleviates Atherosclerotic Calcification by Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis via AMPK/Nrf2 Pathway Open
Background: Atherosclerotic calcification (AC) is a common feature of atherosclerotic cardiovascular disease. β-Hydroxybutyrate (BHB) has been identified as a molecule that influences cardiovascular disease. However, whether BHB can influe…
View article: Analysis of QuantiFERON-TB Gold Plus assay in Children and Adolescents with Latent and Active Tuberculosis in China
Analysis of QuantiFERON-TB Gold Plus assay in Children and Adolescents with Latent and Active Tuberculosis in China Open
Objective To evaluate the accuracy of QuantiFERON-TB Gold Plus (QFT-Plus) assay, and analyze the quantitative interferon gamma (IFN-γ) responses to tuberculosis (TB) antigens and mitogen in children and adolescents with active TB and laten…
View article: Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation
Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation Open
View article: Supplementary Figure S2 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Figure S2 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Figure S2. MPNST cell lines response to combination treatment of trametinib and PDGFRα/β inhibitors.
View article: Supplementary Figure S5 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Figure S5 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Figure S5. Effect of BRAF and CRAF KO on MPNST cells sensitivity to ripretinib treatment.
View article: Supplementary Table S3 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Table S3 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Table S3. Antibodies used for WB and IP.
View article: Supplementary Figure S1 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Figure S1 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Figure S1. MPNST cell lines response to MEKi treatment.
View article: Data from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Data from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Purpose:Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive subtype of soft-tissue sarcoma with a high propensity to metastasize and extremely limited treatment options. Loss of the RAS-GAP NF1 leads to sustained RAF/MEK…
View article: Supplementary Figure S3 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Figure S3 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Figure S3. MPNST cell lines response to trametinib and ripretinib treatment.
View article: Supplementary Figure S4 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Figure S4 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Figure S4. Effect of PDGFRβ KO on MPNST cells sensitivity to trametinib and ripretinib treatment.
View article: Supplementary Figure S6 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Figure S6 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Figure S6. Different MEKi synergize with RAFi in MPNST.
View article: Supplementary Figure S7 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Figure S7 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Figure S7. Change in total tumor volume of MPNST tumor models after trametinib and ripretinib treatment.
View article: Supplementary Table S4 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
Supplementary Table S4 from MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor Open
Supplementary Table S4. Primers used for RT-qPCR.