Tabea Haug
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View article: IR Spectroscopic Studies on Water Confined in an Isoreticular MOF Series–Influence of the Metal and Linker Functionality
IR Spectroscopic Studies on Water Confined in an Isoreticular MOF Series–Influence of the Metal and Linker Functionality Open
Mono‐ and bimetallic MOF‐74 samples with different ratios of Mg 2+ and Ni 2+ (9:1, 7:3, and 1:1), as well as Ni‐MOF‐74 analogs with different pore sizes and functionalities, were loaded with water through the exposure to a controlled relat…
View article: Molecular fluctuations in mixed-metal MOF-74: influence of the metal composition
Molecular fluctuations in mixed-metal MOF-74: influence of the metal composition Open
A selected series of metal–organic frameworks M-MOF-74 (M = Mg, Co, Ni) and mixed metal MM-MOF-74 (Mg/Co or Mg/Ni) with different compositions have been prepared and further investigated by broadband dielectric spectroscopy.
View article: Data from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Data from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Genetic alterations in tumor cells provide promising targets for antitumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibi…
View article: Data from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Data from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Genetic alterations in tumor cells provide promising targets for antitumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibi…
View article: Supplementary Material from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Supplementary Material from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Supplementary table 1 - Antibodies used for flow cytometry analysis; Supplemenary table 2 - Antibodies used for Western blot analysis; Supplemenary table 3 - Primer and PCR conditions used for MDM4 alternative splicing PCR
View article: Supplementary Material from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Supplementary Material from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Supplementary table 1 - Antibodies used for flow cytometry analysis; Supplemenary table 2 - Antibodies used for Western blot analysis; Supplemenary table 3 - Primer and PCR conditions used for MDM4 alternative splicing PCR
View article: Supplementary Figures from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Supplementary Figures from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Supplementary Figure S1 - Evaluation of the synergistic effect of the PRMT5-inhibiting molecules MTA and EPZ015666; Supplementary Figure S2 - PRMT5 inhibition reduces T-cell proliferation, viability and functionality; Supplementary Figure …
View article: Supplementary Figures from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Supplementary Figures from Selective PRMT5 Inhibitors Suppress Human CD8<sup>+</sup> T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Supplementary Figure S1 - Evaluation of the synergistic effect of the PRMT5-inhibiting molecules MTA and EPZ015666; Supplementary Figure S2 - PRMT5 inhibition reduces T-cell proliferation, viability and functionality; Supplementary Figure …
View article: Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens
Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens Open
Background Graft-versus-host-disease (GvHD) is a major problem in allogeneic stem cell transplantation. We previously described two types of endogenous human leukocyte antigen (HLA)-II restricted antigens depending on their behavior toward…
View article: Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA
Selective PRMT5 Inhibitors Suppress Human CD8+ T Cells by Upregulation of p53 and Impairment of the AKT Pathway Similar to the Tumor Metabolite MTA Open
Genetic alterations in tumor cells provide promising targets for antitumor therapy. Recently, loss of methylthioadenosine phosphorylase (MTAP), a deletion frequently occurring in cancer, has been shown to create vulnerability to the inhibi…
View article: Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity
Human Double-Negative Regulatory T-Cells Induce a Metabolic and Functional Switch in Effector T-Cells by Suppressing mTOR Activity Open
The recently discovered population of TCRαβ+ CD4-/CD8- (double-negative, DN) T-cells are highly potent suppressor cells in mice and humans. In preclinical transplantation models, adoptive transfer of DN T-cells specifically inhibits allore…