Tabitha Manson
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View article: On the structural and practical identifiability of multi‐echo BBB‐ASL tracer kinetic models
On the structural and practical identifiability of multi‐echo BBB‐ASL tracer kinetic models Open
Purpose Tracer kinetic models are used in arterial spin labeling (ASL); however, deciding which model parameters to fix or fit is not always trivial. The identifiability of the resultant system of equations is useful to consider, since it …
View article: Measurement of blood–brain barrier water exchange rate using diffusion‐prepared and multi‐echo arterial spin labelling: Comparison of quantitative values and age dependence
Measurement of blood–brain barrier water exchange rate using diffusion‐prepared and multi‐echo arterial spin labelling: Comparison of quantitative values and age dependence Open
Water exchange rate (Kw) across the blood–brain barrier (BBB) is an important physiological parameter that may provide new insight into ageing and neurodegenerative disease. Recently, two non‐invasive arterial spin labelling (ASL) MRI meth…
View article: The relevance of tract‐specific white matter hyperintensity burden to clinical impairment in groups at risk of Alzheimer’s disease
The relevance of tract‐specific white matter hyperintensity burden to clinical impairment in groups at risk of Alzheimer’s disease Open
Background White matter hyperintensities (WMHs) are common in normally functioning older adults. While greater WMH volume may be associated with an increased risk of cognitive dysfunction and dementia, the impact of the location of WMHs is…
View article: Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective
Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective Open
The blood-brain barrier (BBB) consists of specialized cells that tightly regulate the in- and outflow of molecules from the blood to brain parenchyma, protecting the brain’s microenvironment. If one of the BBB components starts to fail, it…